Free for academic non-profit institutions. Other users need a Commercial license
Aliases for SNRNP70 Gene
Aliases for SNRNP70 Gene
External Ids for SNRNP70 Gene
- HGNC: 11150
- Entrez Gene: 6625
- Ensembl: ENSG00000104852
- OMIM: 180740
- UniProtKB: P08621
Previous HGNC Symbols for SNRNP70 Gene
- RNPU1Z
- RPU1
- SNRP70
Previous GeneCards Identifiers for SNRNP70 Gene
- GC19P054285
- GC19P054287
- GC19P049588
- GC19P045964
Summaries for SNRNP70 Gene
GeneCards Summary for SNRNP70 Gene
SNRNP70 (Small Nuclear Ribonucleoprotein U1 Subunit 70) is a Protein Coding gene. Diseases associated with SNRNP70 include Mixed Connective Tissue Disease and Facial Hemiatrophy. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SNRNP35.
UniProtKB/Swiss-Prot Summary for SNRNP70 Gene
-
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158).
-
[Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
-
[Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
Additional gene information for SNRNP70 Gene
- HGNC(11150)
- Entrez Gene(6625)
- Ensembl(ENSG00000104852)
- OMIM(180740)
- UniProtKB(P08621)
- Open Targets Platform(ENSG00000104852)
- Search for SNRNP70 at DataMed
- Search for SNRNP70 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SNRNP70 Gene
Genomics for SNRNP70 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SNRNP70 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SNRNP70 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SNRNP70
- Top Transcription factor binding sites by QIAGEN in the SNRNP70 gene promoter:
-
- CBF(2)
- CBF-A
- CBF-B
- CP1A
- NF-Y
- NF-YA
- NF-YB
- SREBP-1a
- SREBP-1b
- SREBP-1c
Genomic Locations for SNRNP70 Gene
Genomic Locations for SNRNP70 Gene
- chr19:49,085,419-49,108,606
- (GRCh38/hg38)
- Size:
- 23,188 bases
- Orientation:
- Plus strand
- chr19:49,588,465-49,611,870
- (GRCh37/hg19)
- Size:
- 23,406 bases
- Orientation:
- Plus strand
Genomic View for SNRNP70 Gene
Genes around SNRNP70 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
SNRNP70 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SNRNP70 Gene
Proteins for SNRNP70 Gene
-
Protein details for SNRNP70 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08621-RU17_HUMAN
- Recommended name:
- U1 small nuclear ribonucleoprotein 70 kDa
- Protein Accession:
- P08621
- B3KUA3
- P78493
- P78494
- Q15364
- Q15686
- Q15687
- Q15689
- Q99377
- Q9UE45
- Q9UE46
- Q9UE47
- Q9UE48
- Q9UFQ6
Protein attributes for SNRNP70 Gene
- Size:
- 437 amino acids
- Molecular mass:
- 51557 Da
- Quaternary structure:
-
- Component of the U1 snRNP (PubMed:19325628, PubMed:21113136, PubMed:25555158). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (PubMed:19325628, PubMed:21113136, PubMed:25555158). Interacts with SCNM1 (By similarity). Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2 (PubMed:9531537). Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10 (PubMed:10339552). Interacts with dephosphorylated SFRS13A and SFPQ (PubMed:11514619, PubMed:14765198). Interacts with NUDT21/CPSF5, CPSF6, SCAF11, and ZRANB2 (PubMed:14561889, PubMed:11448987, PubMed:9447963). Interacts with GEMIN5 (PubMed:25911097). Interacts with FUS.
- SequenceCaution:
-
- Sequence=CAA28352.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAA29964.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAA29966.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- Major ribonucleoprotein antigen recognized by the sera from patients with autoimmune diseases, such as systemic lupus erythematosus.
Three dimensional structures from OCA and Proteopedia for SNRNP70 Gene
Protein Expression for SNRNP70 Gene
Post-translational modifications for SNRNP70 Gene
- The N-terminus is blocked.
- Extensively phosphorylated on serine residues in the C-terminal region.
-
Ubiquitination at Lys27, Lys87, Lys103, and Lys130
- NX_P08621 (NX_P08621-1)
- Modification sites at PhosphoSitePlus
Other Protein References for SNRNP70 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SNRNP70
-
Abcam antibodies for SNRNP70
- Invitrogen Antibodies for SNRNP70 (AFLGC-SNRNP70)
-
Boster Bio Antibodies for SNRNP70
-
Santa Cruz Biotechnology (SCBT) Antibodies for SNRNP70
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for SNRNP70
- Origene Custom Protein Services for SNRNP70
- ProSpec Recombinant Proteins for SNRNP70
- antibodies-online: Show 8 available SNRNP70 Proteins ranked by validation data
- Compare Top SNRNP70 Proteins
-
Quality Products:
-
Signalway Proteins for SNRNP70
-
Abcam proteins for SNRNP70
Assay Products
- Novus Biologicals ELISA Kits for SNRNP70
- antibodies-online: Show 2 available SNRNP70 Elisa Kits ranked by validation data
- Compare Top SNRNP70 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for SNRNP70 Gene
Domains & Families for SNRNP70 Gene
Gene Families for SNRNP70 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for SNRNP70 Gene
- InterPro:
- Blocks:
-
- RNA-binding region RNP-1 (RNA recognition motif)
- ProtoNet:
Suggested Antigen Peptide Sequences for SNRNP70 Gene
- GenScript: Design optimal peptide antigens:
-
- U1 small nuclear ribonucleoprotein 70 kDa (RU17_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P08621- Domain:
-
- The RRM domain mediates interaction with U1 RNA.
Function for SNRNP70 Gene
Molecular function for SNRNP70 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158).
- UniProtKB/Swiss-Prot Function:
- [Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
- UniProtKB/Swiss-Prot Function:
- [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
Phenotypes From GWAS Catalog for SNRNP70 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | IMP | 2467746 |
| GO:0003729 | mRNA binding | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 9447963 |
| GO:0017069 | snRNA binding | IBA | 21873635 |
Phenotypes for SNRNP70 Gene
- GenomeRNAi human phenotypes for SNRNP70:
-
- Decreased hepcidin::fluc mRNA expression
- no effect
- Decreased viability
- Moderately decreased NFAT1-GFP nuclear translocation
- Increased IL-8 secretion
- Increased gamma-H2AX phosphorylation
- Decreased Salmonella enterica Typhimurium invasion
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- shRNA abundance <= 25%
- Decreased transferrin (TF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased shRNA abundance
- Decreased influenza A/WSN/33 replication
- Decreased influenza A H1N1 (A/WSN/33) virus numbers
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
- Reduced shRNA abundance in FBW7 KO line
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SNRNP70 - Select products 50% OFF >
- * SNRNP70 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SNRNP70
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SNRNP70
-
Santa Cruz Biotechnology (SCBT) CRISPR for SNRNP70
miRNA for SNRNP70 Gene
- miRTarBase miRNAs that target SNRNP70
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SNRNP70
- Browse OriGene Inhibitory RNA Products For SNRNP70
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNRNP70
Clone Products
- Applied Biological Materials (abm): Clones for SNRNP70 - Select products 50% OFF >
- * SNRNP70 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SNRNP70
- Addgene plasmids for SNRNP70
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SNRNP70
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRNP70 Gene
Localization for SNRNP70 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SNRNP70 Gene
- Nucleus speckle. Nucleus, nucleoplasm. Note=Colocalizes with SCNM1 and LUC7L2 in nuclear speckles. {ECO:0000250 UniProtKB:Q62376}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 18559850 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005681 | spliceosomal complex | IDA | 9531537 |
| GO:0005685 | U1 snRNP | IBA,IDA | 21113136 |
| GO:0016607 | nuclear speck | ISS | -- |
Pathways & Interactions for SNRNP70 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.79
|
.47
.41
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for SNRNP70 Gene
1 BioSystems pathway for SNRNP70 Gene
4 Reactome pathways for SNRNP70 Gene
1 KEGG pathway for SNRNP70 Gene
Interacting Proteins for SNRNP70 Gene
Selected Interacting proteins:
P08621-RU17_HUMAN
ENSP00000472998
for SNRNP70 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for SNRNP70
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000398 | mRNA splicing, via spliceosome | IC,TAS | -- |
| GO:0006397 | mRNA processing | IEA | -- |
| GO:0043462 | regulation of ATPase activity | TAS | 25719862 |
| GO:0043484 | regulation of RNA splicing | IMP | 2467746 |
| GO:0048026 | positive regulation of mRNA splicing, via spliceosome | IEA | -- |
No data available for SIGNOR curated interactions for SNRNP70 Gene
Transcripts for SNRNP70 Gene
mRNA/cDNA for SNRNP70 Gene
- 3 REFSEQ mRNAs :
- 30 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000221448 1603 nts (view in UCSC)
- ENST00000401730 3144 nts (view in UCSC)
- ENST00000544278 3221 nts (view in UCSC)
- ENST00000595231 1673 nts (view in UCSC)
- ENST00000597936 580 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SNRNP70 - Select products 50% OFF >
- * SNRNP70 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SNRNP70
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SNRNP70
-
Santa Cruz Biotechnology (SCBT) CRISPR for SNRNP70
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SNRNP70
- Browse OriGene Inhibitory RNA Products For SNRNP70
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNRNP70
Clone Products
- Applied Biological Materials (abm): Clones for SNRNP70 - Select products 50% OFF >
- * SNRNP70 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SNRNP70
- Addgene plasmids for SNRNP70
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SNRNP70
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 12d |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: | |
| SP10: | |
| SP11: | |
| SP12: | |
| SP13: |
Relevant External Links for SNRNP70 Gene
- GeneLoc Exon Structure for
- SNRNP70
Expression for SNRNP70 Gene
This gene is overexpressed in Lymph node (13.4) and Peripheral blood mononuclear cells (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SNRNP70 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SNRNP70
SOURCE GeneReport for Unigene cluster for SNRNP70 Gene:
Hs.467097Evidence on tissue expression from TISSUES for SNRNP70 Gene
- Nervous system(5)
- Liver(4.6)
- Skin(3.9)
- Lung(3.6)
- Kidney(3.6)
- Intestine(3.5)
- Blood(3.1)
- Muscle(3)
- Spleen(3)
- Heart(2.9)
- Lymph node(2.8)
- Eye(2.7)
- Bone marrow(2.7)
- Thyroid gland(2.7)
- Stomach(2.6)
- Pancreas(2.4)
- Adrenal gland(2.4)
- Gall bladder(2.1)
Primer Products
-
OriGene qPCR primer pairs for SNRNP70
-
OriGene qPCR primer pairs and template standards for SNRNP70
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNRNP70 Gene
Orthologs for SNRNP70 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SNRNP70 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | SNRNP70 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | SNRNP70 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | SNRNP70 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Snrnp70 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Snrnp70 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | SNRNP70 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | SNRNP70 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | LOC397946 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.8913 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | snrnp70 31 |
|
OneToOne | |
| wufc20b04 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | snRNP-U1-70K 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | rnp-7 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SNP1 31 33 |
|
OneToMany | |
| Rice (Oryza sativa) |
Liliopsida | Os.4669 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10607 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.649 30 |
|
- Species where no ortholog for SNRNP70 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for SNRNP70 Gene
- ENSEMBL:
- Gene Tree for SNRNP70 (if available)
- TreeFam:
- Gene Tree for SNRNP70 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SNRNP70: view image
Paralogs for SNRNP70 Gene
Variants for SNRNP70 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3619n100 | CNV | gain | 25217958 |
| dgv3620n100 | CNV | gain | 25217958 |
| dgv3621n100 | CNV | gain | 25217958 |
| nsv1071937 | CNV | deletion | 25765185 |
| nsv1112747 | CNV | deletion | 24896259 |
| nsv1134804 | CNV | deletion | 24896259 |
| nsv833857 | CNV | loss | 17160897 |
| nsv833859 | CNV | loss | 17160897 |
| nsv953598 | CNV | deletion | 24416366 |
| nsv9739 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.05;
21.55% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SNRNP70 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SNRNP70
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SNRNP70 Gene
Disorders for SNRNP70 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mixed connective tissue disease |
|
|
| facial hemiatrophy |
|
|
| systemic scleroderma |
|
|
| systemic lupus erythematosus |
|
|
| diffuse scleroderma |
|
|
Search SNRNP70 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SNRNP70
No data available for UniProtKB/Swiss-Prot and Genatlas for SNRNP70 Gene
Publications for SNRNP70 Gene
- Association of polyadenylation cleavage factor I with U1 snRNP. (PMID: 14561889) Awasthi S … Alwine JC (RNA (New York, N.Y.) 2003) 3 4 23
- Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions. (PMID: 11514619) Shav-Tal Y … Zipori D (Molecular biology of the cell 2001) 3 4 23
- Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors. (PMID: 8332490) Woppmann A … Lührmann R (Nucleic acids research 1993) 3 4 23
- Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3. (PMID: 2147422) Spritz RA … Mohrenweiser HW (Genomics 1990) 3 4 23
- Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition. (PMID: 25555158) Kondo Y … Nagai K (eLife 2015) 3 4
ExternalLinks
Products for SNRNP70 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for SNRNP70
- Origene Custom Protein Services for SNRNP70
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SNRNP70
- Browse OriGene Inhibitory RNA Products For SNRNP70
- OriGene qPCR primer pairs for SNRNP70
- OriGene qPCR primer pairs and template standards for SNRNP70
- OriGene CRISPR knockouts for SNRNP70
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SNRNP70
- Sino Biological Human cDNA Clone for SNRNP70
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SNRNP70
- Novus Biologicals proteins and lysates for SNRNP70
- Novus Biologicals ELISA Kits for SNRNP70
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for SNRNP70
- Abcam proteins for SNRNP70
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for SNRNP70 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SNRNP70 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SNRNP70 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SNRNP70 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SNRNP70
- Addgene plasmids for SNRNP70
- antibodies-online: Show 16 available SNRNP70 Antibodies ranked by validation data
- Compare Top SNRNP70 Antibodies
- antibodies-online: Show 2 available SNRNP70 Elisa Kits ranked by validation data
- Compare Top SNRNP70 Elisa Kits
- Quality Products:
- antibodies-online: Show 8 available SNRNP70 Proteins ranked by validation data
- Compare Top SNRNP70 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for SNRNP70
- Search Santa Cruz Biotechnology (SCBT) for SNRNP70 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for SNRNP70
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SNRNP70
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SNRNP70
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SNRNP70
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNRNP70
- Boster Bio Antibodies for SNRNP70
- Browse Boster Bio ELISA Kits
- Signalway Proteins for SNRNP70
Sources for SNRNP70 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172)