Aliases for SNRNP70 Gene
External Ids for SNRNP70 Gene
Previous HGNC Symbols for SNRNP70 Gene
Previous GeneCards Identifiers for SNRNP70 Gene
GeneCards Summary for SNRNP70 Gene
SNRNP70 (Small Nuclear Ribonucleoprotein U1 Subunit 70) is a Protein Coding gene. Diseases associated with SNRNP70 include Mixed Connective Tissue Disease and Facial Hemiatrophy. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SNRNP35.
UniProtKB/Swiss-Prot Summary for SNRNP70 Gene
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158).
[Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
[Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.