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Aliases for SNRNP35 Gene

Aliases for SNRNP35 Gene

  • Small Nuclear Ribonucleoprotein U11/U12 Subunit 35 2 3 5
  • Small Nuclear Ribonucleoprotein 35kDa (U11/U12) 2 3
  • U1 SnRNP-Binding Protein Homolog 3 4
  • U11/U12 SnRNP 35 KDa Protein 3 4
  • Protein HM-1 3 4
  • U11/U12-35K 3 4
  • U1SNRNPBP 3 4
  • U11/U12 Small Nuclear Ribonucleoprotein 35 KDa Protein 3
  • Small Nuclear Ribonucleoprotein, U11/U12 35kDa Subunit 3
  • Small Nuclear Ribonucleoprotein U11/U12 35kDa Subunit 2
  • U1 SnRNP Binding Protein Homolog 2
  • U11/U12 SnRNP 35K 3
  • HM-1 3
  • HM1 4

External Ids for SNRNP35 Gene

Previous GeneCards Identifiers for SNRNP35 Gene

  • GC12P122509
  • GC12P123891
  • GC12P120904
  • GC12P123942

Summaries for SNRNP35 Gene

Entrez Gene Summary for SNRNP35 Gene

  • The protein encoded by this gene is a homolog of the U1-snRNP binding protein. The N-terminal half contains a RNA recognition motif and the C-terminal half is rich in Arg/Asp and Arg/Glu dipeptides, which is a characteristic of a variety of splicing factors. This protein is a component of the U11/U12 small nuclear ribonucleoproteins (snRNP) that form part of the U12-type spliceosome. Alternative splicing results in multiple transcript variants encoding two distinct isoforms and representing a non-protein coding variant. [provided by RefSeq, Aug 2013]

GeneCards Summary for SNRNP35 Gene

SNRNP35 (Small Nuclear Ribonucleoprotein U11/U12 Subunit 35) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and mRNA Splicing - Minor Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is SNRNP70.

Additional gene information for SNRNP35 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRNP35 Gene

Genomics for SNRNP35 Gene

GeneHancer (GH) Regulatory Elements for SNRNP35 Gene

Promoters and enhancers for SNRNP35 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J123457 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 657.4 +1.3 1289 2.8 MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 SP3 MEF2D ZNF610 GLIS1 SNRNP35 PIR40920 RSRC2 DDX55 ZCCHC8 EIF2B1 KNTC1 ATP6V0A2 RILPL2 TCTN2
GH12J123447 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.8 -8.6 -8640 2.4 FOXA2 DMAP1 ZNF121 NFKBIZ SP5 PPARG KAT8 NFIL3 ATF4 MIER3 RILPL2 LOC101927415 CDK2AP1 DNAH10 SNRNP35 C12orf65 ENSG00000270445
GH12J123470 Enhancer 1.1 ENCODE dbSUPER 5.9 +14.2 14166 1.6 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 FOS NFKBIZ SP5 ZHX2 DDX55 RILPL2 TMED2 LOC101927415 RILPL1 EIF2B1 GTF2H3 PITPNM2 SNRNP35 PIR40920
GH12J123119 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 4.2 -336.0 -335950 4.3 SRF PKNOX1 JUNB EBF1 DPF2 BATF IRF4 ATF2 SCRT2 NBN PITPNM2 MPHOSPH9 SNRNP35 C12orf65 HIP1R GC12P123128 ENSG00000280381
GH12J123096 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 4.2 -359.5 -359495 3.4 MEIS2 NFIB ZIC2 RAD21 POLR2A CREM RXRA REST NR2F2 OSR2 PITPNM2 SNRNP35 ENSG00000280381 GC12P123128
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNRNP35 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNRNP35 gene promoter:
  • GR-beta
  • GR-alpha
  • GR
  • AREB6
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • YY1

Genomic Locations for SNRNP35 Gene

Genomic Locations for SNRNP35 Gene
15,514 bases
Plus strand
15,514 bases
Plus strand

Genomic View for SNRNP35 Gene

Genes around SNRNP35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRNP35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRNP35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRNP35 Gene

Proteins for SNRNP35 Gene

  • Protein details for SNRNP35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    U11/U12 small nuclear ribonucleoprotein 35 kDa protein
    Protein Accession:
    Secondary Accessions:
    • A8K262
    • Q5XKN9

    Protein attributes for SNRNP35 Gene

    246 amino acids
    Molecular mass:
    29450 Da
    Quaternary structure:
    • Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.

    Alternative splice isoforms for SNRNP35 Gene


neXtProt entry for SNRNP35 Gene

Post-translational modifications for SNRNP35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNRNP35 Gene

No data available for DME Specific Peptides for SNRNP35 Gene

Domains & Families for SNRNP35 Gene

Gene Families for SNRNP35 Gene

Suggested Antigen Peptide Sequences for SNRNP35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNRNP35: view

No data available for UniProtKB/Swiss-Prot for SNRNP35 Gene

Function for SNRNP35 Gene

Gene Ontology (GO) - Molecular Function for SNRNP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0003729 mRNA binding IBA --
GO:0017069 snRNA binding IBA --
genes like me logo Genes that share ontologies with SNRNP35: view
genes like me logo Genes that share phenotypes with SNRNP35: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNRNP35

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNRNP35 Gene

Localization for SNRNP35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRNP35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNRNP35 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SNRNP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000243 commitment complex IBA --
GO:0005634 nucleus IDA 18559850
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005689 U12-type spliceosomal complex IDA 15146077
genes like me logo Genes that share ontologies with SNRNP35: view

Pathways & Interactions for SNRNP35 Gene

genes like me logo Genes that share pathways with SNRNP35: view

Pathways by source for SNRNP35 Gene

Gene Ontology (GO) - Biological Process for SNRNP35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0008380 RNA splicing IC 15146077
genes like me logo Genes that share ontologies with SNRNP35: view

No data available for SIGNOR curated interactions for SNRNP35 Gene

Drugs & Compounds for SNRNP35 Gene

No Compound Related Data Available

Transcripts for SNRNP35 Gene

Unigene Clusters for SNRNP35 Gene

Small nuclear ribonucleoprotein 35kDa (U11/U12):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNRNP35

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNRNP35 Gene

No ASD Table

Relevant External Links for SNRNP35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNRNP35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNRNP35 Gene

Protein differential expression in normal tissues from HIPED for SNRNP35 Gene

This gene is overexpressed in CD4 Tcells (54.1) and Pancreas (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SNRNP35 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNRNP35 Gene:


SOURCE GeneReport for Unigene cluster for SNRNP35 Gene:


mRNA Expression by UniProt/SwissProt for SNRNP35 Gene:

Tissue specificity: Expressed in heart, liver, skeletal muscle and pancreas.

Evidence on tissue expression from TISSUES for SNRNP35 Gene

  • Nervous system(4.4)
  • Lung(4.3)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with SNRNP35: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNRNP35 Gene

Orthologs for SNRNP35 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SNRNP35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNRNP35 34 33
  • 99.46 (n)
(Monodelphis domestica)
Mammalia SNRNP35 34
  • 88 (a)
(Canis familiaris)
Mammalia SNRNP35 34 33
  • 87.4 (n)
(Bos Taurus)
Mammalia SNRNP35 34 33
  • 86.94 (n)
(Mus musculus)
Mammalia Snrnp35 16 34 33
  • 82.92 (n)
1700128F08Rik 34
  • 49 (a)
(Rattus norvegicus)
Mammalia Snrnp35 33
  • 82.1 (n)
(Ornithorhynchus anatinus)
Mammalia SNRNP35 34
  • 81 (a)
(Gallus gallus)
Aves SNRNP35 34 33
  • 76.61 (n)
(Anolis carolinensis)
Reptilia SNRNP35 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snrnp35 33
  • 68.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25076 33
(Danio rerio)
Actinopterygii snrnp35 34 33
  • 69.25 (n)
Dr.14465 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012250 33
  • 51.87 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNP1 34
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G43370 33
  • 51.4 (n)
(Oryza sativa)
Liliopsida Os09g0513700 33
  • 55.75 (n)
Os.5580 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 56 (a)
Species where no ortholog for SNRNP35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNRNP35 Gene

Gene Tree for SNRNP35 (if available)
Gene Tree for SNRNP35 (if available)
Evolutionary constrained regions (ECRs) for SNRNP35: view image

Paralogs for SNRNP35 Gene

Paralogs for SNRNP35 Gene

genes like me logo Genes that share paralogs with SNRNP35: view

Variants for SNRNP35 Gene

Sequence variations from dbSNP and Humsavar for SNRNP35 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000119773 -- 123,458,720(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000151850 -- 123,470,012(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000266928 -- 123,456,537(+) CCACTGCTGTACTTTCCA/CCA upstream_transcript_variant
rs1000297231 -- 123,464,966(+) A/G 5_prime_UTR_variant, intron_variant
rs1000298129 -- 123,471,448(+) G/C genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNRNP35 Gene

Variant ID Type Subtype PubMed ID
nsv1037260 CNV gain 25217958

Variation tolerance for SNRNP35 Gene

Residual Variation Intolerance Score: 22.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNRNP35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRNP35 Gene

Disorders for SNRNP35 Gene

Additional Disease Information for SNRNP35

No disorders were found for SNRNP35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRNP35 Gene

Publications for SNRNP35 Gene

  1. Cloning and characterization of a family of cDNAs from human histiocyte macrophage cells encoding an arginine-rich basic protein related to the 70 kD U1-snRNP splicing factor. (PMID: 10520751) Adams DS … Czop JK (DNA sequence : the journal of DNA sequencing and mapping 1998) 2 3 4 22 58
  2. The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. (PMID: 15146077) Will CL … Lührmann R (RNA (New York, N.Y.) 2004) 3 4 58
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for SNRNP35 Gene

Sources for SNRNP35 Gene

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