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Aliases for SNRK Gene

Aliases for SNRK Gene

  • SNF Related Kinase 2 3 5
  • SNF1-Related Kinase 3 4
  • SNF-Related Serine/Threonine-Protein Kinase 3
  • SNF-1 Related Kinase 3
  • EC 2.7.11.1 4
  • KIAA0096 4
  • HSNFRK 3
  • SNFRK 4

External Ids for SNRK Gene

Previous GeneCards Identifiers for SNRK Gene

  • GC03P042632
  • GC03P042508
  • GC03P043147
  • GC03P043288

Summaries for SNRK Gene

Entrez Gene Summary for SNRK Gene

  • SNRK is a member of the sucrose nonfermenting (SNF)-related kinase family of serine/threonine kinases (Kertesz et al., 2002 [PubMed 12234663]).[supplied by OMIM, Apr 2009]

GeneCards Summary for SNRK Gene

SNRK (SNF Related Kinase) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MARK3.

UniProtKB/Swiss-Prot for SNRK Gene

  • May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.

Gene Wiki entry for SNRK Gene

Additional gene information for SNRK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNRK Gene

Genomics for SNRK Gene

GeneHancer (GH) Regulatory Elements for SNRK Gene

Promoters and enhancers for SNRK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J043285 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +3.0 2960 8.7 HDGF PKNOX1 ATF1 FOXA2 ARNT ARID4B SIN3A YY1 GLIS2 ZNF207 SNRK RN7SL517P GC03M043165
GH03J043387 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 37 +103.4 103447 4.4 HDAC1 FOXA2 ZBTB40 RAD21 YY1 EGR1 ETV6 ATF7 RXRA ZBTB11 SNRK ABHD5 SNRK-AS1 ENSG00000271941 ANO10 ENSG00000251811 GC03M043165
GH03J043392 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 28.1 +107.5 107524 2.5 RXRA JUN MAX REST RAD21 NR2F2 SP1 EGR1 MYC SNRK SNRK-AS1 ABHD5 ANO10 ENSG00000251811 GC03M043165
GH03J043255 Enhancer 0.9 FANTOM5 Ensembl 30.7 -29.9 -29874 1.7 FOXA3 HLF CEBPB CEBPG ETV5 RARA ZNF395 ATF4 CTBP1 CEBPA SNRK ABHD5 SNRK-AS1 CCDC13 LOC105377052 GC03P043190 GC03M043165
GH03J043316 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.6 +31.3 31325 2.3 ELF3 FOXA2 DNMT3B RAD21 RARA YY1 CREM MIXL1 RXRA SP5 SNRK-AS1 SNRK ABHD5 RN7SL517P ENSG00000271941 GC03M043165
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNRK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNRK gene promoter:
  • p300
  • c-Myb
  • Roaz
  • MRF-2

Genomic Locations for SNRK Gene

Genomic Locations for SNRK Gene
chr3:43,286,512-43,424,764
(GRCh38/hg38)
Size:
138,253 bases
Orientation:
Plus strand
chr3:43,328,004-43,466,256
(GRCh37/hg19)
Size:
138,253 bases
Orientation:
Plus strand

Genomic View for SNRK Gene

Genes around SNRK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNRK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNRK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNRK Gene

Proteins for SNRK Gene

  • Protein details for SNRK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRH2-SNRK_HUMAN
    Recommended name:
    SNF-related serine/threonine-protein kinase
    Protein Accession:
    Q9NRH2
    Secondary Accessions:
    • B2RAV6
    • Q14706
    • Q68D15
    • Q6IQ46
    • Q9NXI7

    Protein attributes for SNRK Gene

    Size:
    765 amino acids
    Molecular mass:
    84276 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA07744.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH18415.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SNRK Gene

    Alternative splice isoforms for SNRK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNRK Gene

Post-translational modifications for SNRK Gene

  • Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNRK Gene

No data available for DME Specific Peptides for SNRK Gene

Domains & Families for SNRK Gene

Gene Families for SNRK Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SNRK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRH2

UniProtKB/Swiss-Prot:

SNRK_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with SNRK: view

Function for SNRK Gene

Molecular function for SNRK Gene

UniProtKB/Swiss-Prot Function:
May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-173.

Enzyme Numbers (IUBMB) for SNRK Gene

Phenotypes From GWAS Catalog for SNRK Gene

Gene Ontology (GO) - Molecular Function for SNRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 12234663
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA,IEA 12234663
GO:0005524 ATP binding IDA,IEA 12234663
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with SNRK: view
genes like me logo Genes that share phenotypes with SNRK: view

Animal Models for SNRK Gene

MGI Knock Outs for SNRK:

Animal Model Products

  • Taconic Biosciences Mouse Models for SNRK

Clone Products

  • Addgene plasmids for SNRK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNRK Gene

Localization for SNRK Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNRK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNRK gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleus (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with SNRK: view

Pathways & Interactions for SNRK Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 12234663
GO:0016310 phosphorylation IEA --
GO:0030099 myeloid cell differentiation TAS 12234663
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with SNRK: view

No data available for Pathways by source and SIGNOR curated interactions for SNRK Gene

Drugs & Compounds for SNRK Gene

(3) Drugs for SNRK Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for SNRK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with SNRK: view

Transcripts for SNRK Gene

mRNA/cDNA for SNRK Gene

Unigene Clusters for SNRK Gene

SNF related kinase:
Representative Sequences:

Clone Products

  • Addgene plasmids for SNRK

Alternative Splicing Database (ASD) splice patterns (SP) for SNRK Gene

No ASD Table

Relevant External Links for SNRK Gene

GeneLoc Exon Structure for
SNRK
ECgene alternative splicing isoforms for
SNRK

Expression for SNRK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNRK Gene

Protein differential expression in normal tissues from HIPED for SNRK Gene

This gene is overexpressed in Liver, secretome (22.8), CD8 Tcells (11.0), Frontal cortex (10.0), and CD4 Tcells (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SNRK Gene



Protein tissue co-expression partners for SNRK Gene

NURSA nuclear receptor signaling pathways regulating expression of SNRK Gene:

SNRK

SOURCE GeneReport for Unigene cluster for SNRK Gene:

Hs.476052

mRNA Expression by UniProt/SwissProt for SNRK Gene:

Q9NRH2-SNRK_HUMAN
Tissue specificity: Expressed in hematopoietic progenitor cells and leukemic cell lines. Weakly expressed in the testis.

Evidence on tissue expression from TISSUES for SNRK Gene

  • Nervous system(4.8)
  • Liver(4.2)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with SNRK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNRK Gene

Orthologs for SNRK Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SNRK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNRK 34 33
  • 99.56 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNRK 34
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SNRK 34
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNRK 34 33
  • 88.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SNRK 34 33
  • 86.44 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Snrk 16 34 33
  • 84.25 (n)
rat
(Rattus norvegicus)
Mammalia Snrk 33
  • 83.98 (n)
chicken
(Gallus gallus)
Aves SNRK 34 33
  • 80.7 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNRK 34
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia snrk 33
  • 76.57 (n)
zebrafish
(Danio rerio)
Actinopterygii snrka 34 33
  • 70 (n)
OneToOne
zgc73231 33
fruit fly
(Drosophila melanogaster)
Insecta CG8485 34
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK524.4 34
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KCC4 34
  • 17 (a)
ManyToMany
GIN4 34
  • 16 (a)
ManyToMany
HSL1 34
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 70 (a)
OneToOne
Species where no ortholog for SNRK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SNRK Gene

ENSEMBL:
Gene Tree for SNRK (if available)
TreeFam:
Gene Tree for SNRK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SNRK: view image

Paralogs for SNRK Gene

Paralogs for SNRK Gene

genes like me logo Genes that share paralogs with SNRK: view

Variants for SNRK Gene

Sequence variations from dbSNP and Humsavar for SNRK Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs368877591 An ovarian mucinous carcinoma sample 43,348,090(+) G/A coding_sequence_variant, missense_variant
VAR_041099 An ovarian serous carcinoma sample p.Pro748Leu
VAR_041100 A breast pleomorphic lobular carcinoma sample p.Ile765Met
rs1000008736 -- 43,288,983(+) A/G intron_variant
rs1000024042 -- 43,294,764(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SNRK Gene

Variant ID Type Subtype PubMed ID
nsv590160 CNV loss 21841781
nsv590159 CNV gain+loss 21841781
nsv590156 CNV gain+loss 21841781
nsv1144988 CNV deletion 24896259
nsv1072252 CNV deletion 25765185
nsv1009102 CNV gain 25217958
esv3596011 CNV gain 21293372
esv3561802 CNV deletion 23714750
esv2752008 CNV gain 17911159
esv22433 CNV loss 19812545
dgv8300n54 CNV gain 21841781
dgv8299n54 CNV gain 21841781
dgv8298n54 CNV loss 21841781

Variation tolerance for SNRK Gene

Residual Variation Intolerance Score: 5.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNRK Gene

Human Gene Mutation Database (HGMD)
SNRK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNRK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNRK Gene

Disorders for SNRK Gene

Additional Disease Information for SNRK

No disorders were found for SNRK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNRK Gene

Publications for SNRK Gene

  1. Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases. (PMID: 12234663) Kertesz N … Labastie MC (Gene 2002) 3 4 22 58
  2. Molecular cloning and characterization of a novel mammalian protein kinase harboring a homology domain that defines a subfamily of serine/threonine kinases. (PMID: 8654423) Becker W … Joost HG (European journal of biochemistry 1996) 2 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T … Kotani H (DNA research : an international journal for rapid publication of reports on genes and genomes 1995) 2 3 4 58
  4. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. (PMID: 15733851) Jaleel M … Alessi DR (FEBS letters 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for SNRK Gene

  • Addgene plasmids for SNRK

Sources for SNRK Gene

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