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Aliases for SNORD74B Gene

Subcategory (RNA class) for SNORD74B Gene

snoRNA

Quality Score for this RNA gene is

5

Aliases for SNORD74B Gene

  • Small Nucleolar RNA, C/D Box 74B 2 3 5

External Ids for SNORD74B Gene

ORGUL Members for SNORD74B Gene

Previous GeneCards Identifiers for SNORD74B Gene

  • GC00U936754
  • GC21U900878

Summaries for SNORD74B Gene

GeneCards Summary for SNORD74B Gene

SNORD74B (Small Nucleolar RNA, C/D Box 74B) is an RNA Gene, and is affiliated with the snoRNA class.

fRNAdb sequence ontologies for SNORD74B Gene - the ORGUL cluster for this gene includes several descriptions:

  • C_D_box_snoRNA: Most box C/D snoRNAs also contain long (>10 nt) sequences complementary to rRNA. Boxes C and D, as well as boxes C' and D', are usually located in close proximity, and form a structure known as the box C/D motif. This motif is important for snoRNA stability, processing, nucleolar targeting and function. A small number of box C/D snoRNAs are involved in rRNA processing; most, however, are known or predicted to serve as guide RNAs in ribose methylation of rRNA. Targeting involves direct base pairing of the snoRNA at the rRNA site to be modified and selection of a rRNA nucleotide a fixed distance from box D or D'.

  • Small nucleolar RNA SNORD74: Z18 also identified as U74 (SNORD74) belongs to the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [1]. U74 is predicted to guide the 2'O-ribose methylation of 28S rRNA residue C3820 [3]. In humans U74 shares the same non-protein coding host gene (gas5) with 9 other snoRNAs (U44, U47, U75, U76, U77, U78, U79, U80 and U81)[2].

Additional gene information for SNORD74B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORD74B Gene

Genomics for SNORD74B Gene

GeneHancer (GH) Regulatory Elements for SNORD74B Gene

Promoters and enhancers for SNORD74B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21I016307 Enhancer 1.6 VISTA FANTOM5 Ensembl ENCODE dbSUPER 11.7 -24.1 -24098 3.3 USF1 ZSCAN26 JUNB CEBPB BATF ATF2 RFX5 ATF7 PRDM1 ENSG00000270071 SNORD74B MIR99AHG GC21P016344
GH21I016304 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.8 -21.1 -21072 2 FOXA2 POLR2A L3MBTL2 HNF4A ATF7 ATF2 YY1 SNORD74B ENSG00000270071 GC21M016286 MIR99AHG
GH21I016123 Enhancer 0.9 Ensembl ENCODE 10 +160.0 159982 1.7 MXI1 PKNOX1 JUN MAX BRCA1 ZNF664 POLR2A RCOR1 FOSL2 FOS SNORD74B RPS26P5 GC21M016286 MIR99AHG
GH21I016159 Enhancer 0.3 ENCODE 10.2 +125.3 125342 0.2 FOSL2 SNORD74B RPS26P5 GC21M016286 MIR99AHG
GH21I016264 Enhancer 0.2 ENCODE 12 +20.1 20072 0.8 SNORD74B GC21M016286 RPS26P5 MIR99AHG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNORD74B on UCSC Golden Path with GeneCards custom track

Genomic Locations for SNORD74B Gene

Genomic Locations for SNORD74B Gene
chr21:16,284,696-16,284,768
(GRCh38/hg38)
Size:
73 bases
Orientation:
Minus strand
chr21:17,657,017-17,657,089
(GRCh37/hg19)

Genomic View for SNORD74B Gene

Genes around SNORD74B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORD74B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORD74B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

ORGUL Member Location for SNORD74B Gene

ORGUL Member Location for SNORD74B gene

No data available for RefSeq DNA sequence for SNORD74B Gene

Proteins for SNORD74B Gene

Post-translational modifications for SNORD74B Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORD74B Gene

Domains & Families for SNORD74B Gene

Gene Families for SNORD74B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORD74B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORD74B Gene

Function for SNORD74B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORD74B Gene

Localization for SNORD74B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SNORD74B Gene

Pathways & Interactions for SNORD74B Gene

SuperPathways for SNORD74B Gene

No Data Available

Interacting Proteins for SNORD74B Gene

Gene Ontology (GO) - Biological Process for SNORD74B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNORD74B Gene

Drugs & Compounds for SNORD74B Gene

No Compound Related Data Available

Transcripts for SNORD74B Gene

mRNA/cDNA for SNORD74B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SNORD74B Gene

No ASD Table

Relevant External Links for SNORD74B Gene

GeneLoc Exon Structure for
SNORD74B
ECgene alternative splicing isoforms for
SNORD74B

Expression for SNORD74B Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORD74B Gene

Orthologs for SNORD74B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORD74B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORD74 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm26224 34
  • 68 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SNORD74 34
  • 63 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SNORD74 34 34
  • 57 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SNORD74 34
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SNORD74 34
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii SNORD74 34
  • 64 (a)
OneToMany
Species where no ortholog for SNORD74B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNORD74B Gene

ENSEMBL:
Gene Tree for SNORD74B (if available)
TreeFam:
Gene Tree for SNORD74B (if available)

Paralogs for SNORD74B Gene

No data available for Paralogs for SNORD74B Gene

Variants for SNORD74B Gene

Additional Variant Information for SNORD74B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORD74B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SNORD74B Gene

Disorders for SNORD74B Gene

Additional Disease Information for SNORD74B

No disorders were found for SNORD74B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNORD74B Gene

Publications for SNORD74B Gene

  1. An updated human snoRNAome. (PMID: 27174936) Jorjani H … Gruber AR (Nucleic acids research 2016) 2 3 58
  2. Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro. (PMID: 12215523) Galardi S … Bozzoni I (Molecular and cellular biology 2002) 1
  3. Classification of gas5 as a multi-small-nucleolar-RNA (snoRNA) host gene and a member of the 5'-terminal oligopyrimidine gene family reveals common features of snoRNA host genes. (PMID: 9819378) Smith CM … Steitz JA (Molecular and cellular biology 1998) 1

Products for SNORD74B Gene

Sources for SNORD74B Gene

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