Subcategory (RNA class) for SNORD74B Gene
Quality Score for this RNA gene is
Previous GeneCards Identifiers for SNORD74B Gene
GeneCards Summary for SNORD74B Gene
SNORD74B (Small Nucleolar RNA, C/D Box 74B) is an RNA Gene, and is affiliated with the snoRNA class.
fRNAdb sequence ontologies for SNORD74B Gene - the ORGUL cluster for this gene includes several descriptions:
C_D_box_snoRNA: Most box C/D snoRNAs also contain long (>10 nt) sequences complementary to rRNA. Boxes C and D, as well as boxes C' and D', are usually located in close proximity, and form a structure known as the box C/D motif. This motif is important for snoRNA stability, processing, nucleolar targeting and function. A small number of box C/D snoRNAs are involved in rRNA processing; most, however, are known or predicted to serve as guide RNAs in ribose methylation of rRNA. Targeting involves direct base pairing of the snoRNA at the rRNA site to be modified and selection of a rRNA nucleotide a fixed distance from box D or D'.
Small nucleolar RNA SNORD74: Z18 also identified as U74 (SNORD74) belongs to the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs . U74 is predicted to guide the 2'O-ribose methylation of 28S rRNA residue C3820 . In humans U74 shares the same non-protein coding host gene (gas5) with 9 other snoRNAs (U44, U47, U75, U76, U77, U78, U79, U80 and U81).