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Aliases for SNORD50B Gene

Subcategory (RNA class) for SNORD50B Gene

snoRNA

Quality Score for this RNA gene is

13

Aliases for SNORD50B Gene

  • Small Nucleolar RNA, C/D Box 50B 2 3 5
  • U50B 3
  • U50 3

External Ids for SNORD50B Gene

ORGUL Members for SNORD50B Gene

Previous GeneCards Identifiers for SNORD50B Gene

  • GC06U900827
  • GC06M086449
  • GC06M086456
  • GC06M086460
  • GC06M086464
  • GC06M086388
  • GC06M086390
  • GC06M083613
  • GC06M086392
  • GC06M085678
  • GC06M085680
  • GC06M085681
  • GC06M085682
  • GC06M085683
  • GC06M085684
  • GC06M085685
  • GC06M085686

Summaries for SNORD50B Gene

Entrez Gene Summary for SNORD50B Gene

  • SNORD50B is a C/D box-type small nucleolar RNA (snoRNA) that is predicted to function as a guide RNA in 2-prime O-methylation of 28S ribosomal RNA (Tanaka et al., 2000 [PubMed 10792466]).[supplied by OMIM, Feb 2010]

GeneCards Summary for SNORD50B Gene

SNORD50B (Small Nucleolar RNA, C/D Box 50B) is an RNA Gene, and is affiliated with the snoRNA class.

Additional gene information for SNORD50B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNORD50B Gene

Genomics for SNORD50B Gene

GeneHancer (GH) Regulatory Elements for SNORD50B Gene

Promoters and enhancers for SNORD50B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J085674 Promoter/Enhancer 1.6 Ensembl ENCODE 650.7 +0.0 34 6.5 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SNHG5 GC06M085679 GC06M085688 GC06M085689 SNORD50A SNORD50B SYNCRIP LOC100127917 KRT18P64
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNORD50B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNORD50B gene promoter:
  • Pbx1a
  • POU2F1a
  • POU2F1
  • Egr-4
  • Egr-2
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • TFIID

Genomic Locations for SNORD50B Gene

Genomic Locations for SNORD50B Gene
chr6:85,677,589-85,677,659
(GRCh38/hg38)
Size:
71 bases
Orientation:
Minus strand
chr6:86,370,710-86,388,451
(GRCh37/hg19)
Size:
17,742 bases
Orientation:
Minus strand

Genomic View for SNORD50B Gene

Genes around SNORD50B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORD50B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORD50B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORD50B Gene

Proteins for SNORD50B Gene

Post-translational modifications for SNORD50B Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORD50B Gene

Domains & Families for SNORD50B Gene

Gene Families for SNORD50B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORD50B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORD50B Gene

Function for SNORD50B Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORD50B Gene

Localization for SNORD50B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SNORD50B Gene

Pathways & Interactions for SNORD50B Gene

SuperPathways for SNORD50B Gene

No Data Available

Interacting Proteins for SNORD50B Gene

Gene Ontology (GO) - Biological Process for SNORD50B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNORD50B Gene

Drugs & Compounds for SNORD50B Gene

No Compound Related Data Available

Transcripts for SNORD50B Gene

mRNA/cDNA for SNORD50B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(2) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNORD50B Gene

No ASD Table

Relevant External Links for SNORD50B Gene

GeneLoc Exon Structure for
SNORD50B
ECgene alternative splicing isoforms for
SNORD50B

Expression for SNORD50B Gene

NURSA nuclear receptor signaling pathways regulating expression of SNORD50B Gene:

SNORD50B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORD50B Gene

Orthologs for SNORD50B Gene

Evolution for SNORD50B Gene

ENSEMBL:
Gene Tree for SNORD50B (if available)
TreeFam:
Gene Tree for SNORD50B (if available)

No data available for Orthologs for SNORD50B Gene

Paralogs for SNORD50B Gene

No data available for Paralogs for SNORD50B Gene

Variants for SNORD50B Gene

Sequence variations from dbSNP and Humsavar for SNORD50B Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000212406 -- 85,678,697(-) C/G/T upstream_transcript_variant
rs1001045088 -- 85,678,907(-) G/A/T upstream_transcript_variant
rs1001491918 -- 85,678,694(-) C/A upstream_transcript_variant
rs1001943933 -- 85,678,542(-) AT/ upstream_transcript_variant
rs1002543775 -- 85,679,154(-) GGCTGGCTGGCTGGCTGGC/GGCTGGCTGGCTGGC upstream_transcript_variant

Additional Variant Information for SNORD50B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORD50B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SNORD50B Gene

Disorders for SNORD50B Gene

Additional Disease Information for SNORD50B

No disorders were found for SNORD50B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNORD50B Gene

Publications for SNORD50B Gene

  1. Intronic U50 small-nucleolar-RNA (snoRNA) host gene of no protein-coding potential is mapped at the chromosome breakpoint t(3;6)(q27;q15) of human B-cell lymphoma. (PMID: 10792466) Tanaka R … Mori S (Genes to cells : devoted to molecular & cellular mechanisms 2000) 2 3 58
  2. The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer. (PMID: 26595770) Siprashvili Z … Khavari PA (Nature genetics 2016) 3 58
  3. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PMID: 22751105) Chu L … Tomasson MH (The Journal of clinical investigation 2012) 3 58
  4. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. (PMID: 20195266) Adkins DE … van den Oord EJ (Molecular psychiatry 2011) 44 58
  5. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G … Montanini B (Genomics 2009) 3 58

Products for SNORD50B Gene

Sources for SNORD50B Gene

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