Intronic regions of ribosomal protein genes can harbor noncoding small nucleolar RNAs (snoRNAs), like SNORD43, which are generated during pre-mRNA processing. snoRNAs form part of the small nucleolar ribonucleoprotein particles (snoRNPs) involved in pre-rRNA processing and modification. snoRNAs of the box C/D class, like SNORD43, function in 2-prime-O-ribose methylation of rRNA... See more...

Aliases for SNORD43 Gene

Subcategory (RNA class) for SNORD43 Gene

snoRNA

Number of RNA Genes sources:

3 / 14

Aliases for SNORD43 Gene

  • Small Nucleolar RNA, C/D Box 43 2 3 5
  • RNA, U43 Small Nuclear 2 3
  • SNORD43 2 174
  • U43 Small Nucleolar RNA 3
  • U43 Small Nuclear RNA 3
  • U43 SnoRNA 3
  • RF00221 172
  • RNU43 3
  • U43 3

External Ids for SNORD43 Gene

Previous HGNC Symbols for SNORD43 Gene

  • RNU43

Previous GeneCards Identifiers for SNORD43 Gene

  • GC22M038045
  • GC22M039708
  • GC22M039716
  • GC22M039718
  • GC22M039720
  • GC22M039722
  • GC22M039726
  • GC22M039820
  • GC22M040107
  • GC22M039442
  • GC22M039842
  • GC22M043821
  • GC22M044200
  • GC22M044528
  • GC22M039856
  • GC22M039971
  • GC22M040663
  • GC22M041112
  • GC22M041516
  • GC22M041933
  • GC22M042365
  • GC22M043449

Summaries for SNORD43 Gene

Entrez Gene Summary for SNORD43 Gene

  • Intronic regions of ribosomal protein genes can harbor noncoding small nucleolar RNAs (snoRNAs), like SNORD43, which are generated during pre-mRNA processing. snoRNAs form part of the small nucleolar ribonucleoprotein particles (snoRNPs) involved in pre-rRNA processing and modification. snoRNAs of the box C/D class, like SNORD43, function in 2-prime-O-ribose methylation of rRNAs (Duga et al., 2000 [PubMed 10684968]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SNORD43 Gene

SNORD43 (Small Nucleolar RNA, C/D Box 43) is an RNA Gene, and is affiliated with the snoRNA class.

Rfam classification for SNORD43 Gene

  • Small nucleolar RNA SNORD43

Additional gene information for SNORD43 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORD43 Gene

Genomics for SNORD43 Gene

GeneHancer (GH) Regulatory Elements for SNORD43 Gene

Promoters and enhancers for SNORD43 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J039315 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +1.1 1092 6 EP300 ZBTB40 CTCF SIN3A TCF12 NRF1 POLR2G SP1 GTF2E2 PHF8 RPL3 SNORD43 SNORD139 lnc-PDGFB-2 piR-30799 piR-57460-459 CBX7 DDX17 SNORD83B PRDX3P1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNORD43 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNORD43 gene promoter:
  • AML1a
  • ATF6
  • Bach2
  • CUTL1
  • ER-alpha
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2

Genomic Locations for SNORD43 Gene

Genomic Locations for SNORD43 Gene
chr22:39,319,050-39,319,113
(GRCh38/hg38)
Size:
64 bases
Orientation:
Minus strand
chr22:39,715,055-39,715,118
(GRCh37/hg19)
Size:
64 bases
Orientation:
Minus strand

Genomic View for SNORD43 Gene

Genes around SNORD43 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORD43 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORD43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORD43 Gene

Proteins for SNORD43 Gene

Post-translational modifications for SNORD43 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORD43 Gene

Domains & Families for SNORD43 Gene

Gene Families for SNORD43 Gene

genes like me logo Genes that share domains with SNORD43: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SNORD43 Gene

Function for SNORD43 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORD43 Gene

Localization for SNORD43 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNORD43 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SNORD43 Gene

Pathways & Interactions for SNORD43 Gene

PathCards logo

SuperPathways for SNORD43 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for SNORD43 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for SNORD43 Gene

Drugs & Compounds for SNORD43 Gene

No Compound Related Data Available

Transcripts for SNORD43 Gene

mRNA/cDNA for SNORD43 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 ENA transcripts :
1 Rfam transcripts :
1 snOPY transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for SNORD43 Gene

No ASD Table

Relevant External Links for SNORD43 Gene

GeneLoc Exon Structure for
SNORD43

Expression for SNORD43 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNORD43 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SNORD43

genes like me logo Genes that share expression patterns with SNORD43: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORD43 Gene

Orthologs for SNORD43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORD43 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORD43 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SNORD43 31
  • 92 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SNORD43 31
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SNORD43 31
  • 59 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SNORD43 31
  • 58 (a)
OneToMany
Species where no ortholog for SNORD43 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SNORD43 Gene

ENSEMBL:
Gene Tree for SNORD43 (if available)
TreeFam:
Gene Tree for SNORD43 (if available)

Paralogs for SNORD43 Gene

No data available for Paralogs for SNORD43 Gene

Variants for SNORD43 Gene

Additional dbSNP identifiers (rs#s) for SNORD43 Gene

Structural Variations from Database of Genomic Variants (DGV) for SNORD43 Gene

Variant ID Type Subtype PubMed ID
nsv834198 CNV loss 17160897

Additional Variant Information for SNORD43 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORD43

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SNORD43 Gene

Disorders for SNORD43 Gene

Additional Disease Information for SNORD43

No disorders were found for SNORD43 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNORD43 Gene

Publications for SNORD43 Gene

  1. Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs. (PMID: 8674114) Kiss-László Z … Kiss T (Cell 1996) 2 3 54
  2. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G … Montanini B (Genomics 2009) 3 54
  3. The intron-containing L3 ribosomal protein gene (RPL3): sequence analysis and identification of U43 and of two novel intronic small nucleolar RNAs. (PMID: 10684968) Duga S … Simonic T (Biochimica et biophysica acta 2000) 3 54

Products for SNORD43 Gene

Sources for SNORD43 Gene