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Aliases for SNORD25 Gene

Subcategory (RNA class) for SNORD25 Gene

snoRNA

Quality Score for this RNA gene is

17

Aliases for SNORD25 Gene

  • Small Nucleolar RNA, C/D Box 25 2 3 5
  • RNA, U25 Small Nucleolar 2 3
  • RNU25 3
  • U25 3

External Ids for SNORD25 Gene

Previous HGNC Symbols for SNORD25 Gene

  • RNU25

Previous GeneCards Identifiers for SNORD25 Gene

  • GC11M062400
  • GC11M062408
  • GC11M062418
  • GC11M062427
  • GC11M062631
  • GC11M062636
  • GC11M058957
  • GC11M062645
  • GC11M062650
  • GC11M062655
  • GC11M062662
  • GC11M062672
  • GC11M062861
  • GC11M062871
  • GC11M062880
  • GC11M062891
  • GC11M062900
  • GC11M062909
  • GC11M062918
  • GC11M062928

Summaries for SNORD25 Gene

GeneCards Summary for SNORD25 Gene

SNORD25 (Small Nucleolar RNA, C/D Box 25) is an RNA Gene, and is affiliated with the snoRNA class.

fRNAdb sequence ontologies for SNORD25 Gene - the ORGUL cluster for this gene includes several descriptions:

  • C_D_box_snoRNA: Most box C/D snoRNAs also contain long (>10 nt) sequences complementary to rRNA. Boxes C and D, as well as boxes C' and D', are usually located in close proximity, and form a structure known as the box C/D motif. This motif is important for snoRNA stability, processing, nucleolar targeting and function. A small number of box C/D snoRNAs are involved in rRNA processing; most, however, are known or predicted to serve as guide RNAs in ribose methylation of rRNA. Targeting involves direct base pairing of the snoRNA at the rRNA site to be modified and selection of a rRNA nucleotide a fixed distance from box D or D'.

  • Small nucleolar RNA SNORD25: U25 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs. U25 is found in gene clusters in plants [1], and within the U22 snoRNA host gene (UHG) in mammals [2]. U25 is thought to as a 2'-O-ribose methylation guide for ribosomal RNA. This RNA has also been named snoRNA R73 in some plants.

View fRNAdb secondary structures for SNORD25

Additional gene information for SNORD25 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORD25 Gene

Genomics for SNORD25 Gene

GeneHancer (GH) Regulatory Elements for SNORD25 Gene

Promoters and enhancers for SNORD25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J062852 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 -0.2 -205 5.9 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NXF1 SNHG1 SLC3A2 ENSG00000278527 GC11M062919 GC11M062925 GC11M062934 GC11M062938 GC11M062939 GC11M062942
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNORD25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNORD25 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • SREBP-1c
  • SREBP-1b

Genomic Locations for SNORD25 Gene

Genomic Locations for SNORD25 Gene
chr11:62,855,564-62,855,632
(GRCh38/hg38)
Size:
69 bases
Orientation:
Minus strand
chr11:62,619,460-62,623,386
(GRCh37/hg19)
Size:
3,927 bases
Orientation:
Minus strand

Genomic View for SNORD25 Gene

Genes around SNORD25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORD25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORD25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORD25 Gene

ORGUL Member Location for SNORD25 Gene

ORGUL Member Location for SNORD25 gene

Proteins for SNORD25 Gene

Post-translational modifications for SNORD25 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORD25 Gene

Domains & Families for SNORD25 Gene

Gene Families for SNORD25 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORD25: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORD25 Gene

Function for SNORD25 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORD25 Gene

Localization for SNORD25 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SNORD25 Gene

Pathways & Interactions for SNORD25 Gene

SuperPathways for SNORD25 Gene

No Data Available

Interacting Proteins for SNORD25 Gene

Gene Ontology (GO) - Biological Process for SNORD25 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNORD25 Gene

Drugs & Compounds for SNORD25 Gene

No Compound Related Data Available

Transcripts for SNORD25 Gene

fRNAdb Secondary structures for SNORD25 Gene

  • FR302959

mRNA/cDNA for SNORD25 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(2) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNORD25 Gene

No ASD Table

Relevant External Links for SNORD25 Gene

GeneLoc Exon Structure for
SNORD25
ECgene alternative splicing isoforms for
SNORD25

Expression for SNORD25 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNORD25 Gene:

SNORD25
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORD25 Gene

Orthologs for SNORD25 Gene

Evolution for SNORD25 Gene

ENSEMBL:
Gene Tree for SNORD25 (if available)
TreeFam:
Gene Tree for SNORD25 (if available)

No data available for Orthologs for SNORD25 Gene

Paralogs for SNORD25 Gene

No data available for Paralogs for SNORD25 Gene

Variants for SNORD25 Gene

Sequence variations from dbSNP and Humsavar for SNORD25 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000055291 -- 62,855,272(-) T/G downstream_transcript_variant
rs1000661059 -- 62,855,896(-) C/T upstream_transcript_variant
rs1000988950 -- 62,855,843(-) T/C upstream_transcript_variant
rs1001419761 -- 62,855,320(-) T/C downstream_transcript_variant
rs1002424048 -- 62,855,938(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNORD25 Gene

Variant ID Type Subtype PubMed ID
nsv1159903 CNV duplication 26073780
nsv508636 CNV deletion 20534489
nsv509416 CNV insertion 20534489

Additional Variant Information for SNORD25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORD25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORD25 Gene

Disorders for SNORD25 Gene

Additional Disease Information for SNORD25

No disorders were found for SNORD25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNORD25 Gene

Publications for SNORD25 Gene

  1. The U22 host gene (UHG): chromosomal localization of UHG and distribution of U22 small nucleolar RNA. (PMID: 9387929) Frey MR … Matera AG (Histochemistry and cell biology 1997) 2 3 58
  2. A mammalian gene with introns instead of exons generating stable RNA products. (PMID: 8559254) Tycowski KT … Steitz JA (Nature 1996) 1 3 58
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  4. Genomic analysis of high-risk smoldering multiple myeloma. (PMID: 22331267) López-Corral L … Gutiérrez NC (Haematologica 2012) 3 58
  5. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G … Montanini B (Genomics 2009) 3 58

Products for SNORD25 Gene

Sources for SNORD25 Gene

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