This gene encodes a small nucleolar RNA (snoRNA) that may be involved in biogenesis of the large (28S) ribosomal subunit. This gene is found within an intron of the RPL5 gene. [provided by RefSeq, Mar 2009] See more...

Aliases for SNORD21 Gene

Data sources for SNORD21 Gene:

RNA type for SNORD21 Gene

snoRNA

Aliases for SNORD21 Gene

External Ids for SNORD21 Gene

Previous HGNC Symbols for SNORD21 Gene

  • RNU21

Previous GeneCards Identifiers for SNORD21 Gene

  • GC01P093075
  • GC01P093302

Summaries for SNORD21 Gene

Entrez Gene Summary for SNORD21 Gene

  • This gene encodes a small nucleolar RNA (snoRNA) that may be involved in biogenesis of the large (28S) ribosomal subunit. This gene is found within an intron of the RPL5 gene. [provided by RefSeq, Mar 2009]

GeneCards Summary for SNORD21 Gene

SNORD21 (Small Nucleolar RNA, C/D Box 21) is an RNA Gene, and is affiliated with the snoRNA class.

Rfam classification for SNORD21 Gene

  • Small nucleolar RNA SNORD21

Additional gene information for SNORD21 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORD21 Gene

Genomics for SNORD21 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SNORD21 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNORD21 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the SNORD21 gene promoter:
  • AML1a
  • AREB6
  • C/EBPalpha
  • Elk-1
  • HSF2
  • MyoD
  • PPAR-gamma1
  • PPAR-gamma2
  • Sox9

Genomic Locations for SNORD21 Gene

Latest Assembly
chr1:92,837,289-92,837,383
(GRCh38/hg38)
Size:
95 bases
Orientation:
Plus strand

Previous Assembly
chr1:93,302,846-93,302,940
(GRCh37/hg19 by Entrez Gene)
Size:
95 bases
Orientation:
Plus strand

chr1:93,302,846-93,302,940
(GRCh37/hg19 by Ensembl)
Size:
95 bases
Orientation:
Plus strand

Genomic View for SNORD21 Gene

Genes around SNORD21 on UCSC Golden Path with GeneCards custom track
SNORD21 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
SNORD21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORD21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORD21 Gene

Proteins for SNORD21 Gene

Post-translational modifications for SNORD21 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORD21 Gene

Domains & Families for SNORD21 Gene

Gene Families for SNORD21 Gene

genes like me logo Genes that share domains with SNORD21: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SNORD21 Gene

Function for SNORD21 Gene

Phenotypes From GWAS Catalog for SNORD21 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORD21 Gene

Localization for SNORD21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNORD21 gene
Compartment Confidence
lysosome 2
plasma membrane 1
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SNORD21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with SNORD21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SNORD21 Gene

Pathways & Interactions for SNORD21 Gene

PathCards logo

SuperPathways for SNORD21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNORD21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with SNORD21: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for SNORD21 Gene

Drugs & Compounds for SNORD21 Gene

No Compound Related Data Available

Transcripts for SNORD21 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for SNORD21 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00002E0A2C_9606 snoRNA 95 6

RefSeq: NR_000006,

Ensembl: ENST00000383953 (view in UCSC) ,

Rfam: RF00068,

snoDB: SNODB107,

snOPY: Homo_sapiens300669,

ENA: Z35312.1:944..1038:ncRNA,

URS0001BC08F5_9606 snoRNA 95 1

Rfam: RF00068,

SNORD21 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for SNORD21 Gene

No ASD Table

Relevant External Links for SNORD21 Gene

GeneLoc Exon Structure for
SNORD21

No data available for mRNA/cDNA for SNORD21 Gene

Expression for SNORD21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNORD21 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SNORD21

genes like me logo Genes that share expression patterns with SNORD21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORD21 Gene

Orthologs for SNORD21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORD21 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SNORD21 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia SNORD21 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia SNORD21 30
  • 97 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Snord21 30
  • 87 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SNORD21 30
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SNORD21 30
  • 75 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SNORD21 30 30
  • 75 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii SNORD21 30
  • 58 (a)
OneToOne
Species where no ortholog for SNORD21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SNORD21 Gene

ENSEMBL:
Gene Tree for SNORD21 (if available)
TreeFam:
Gene Tree for SNORD21 (if available)
Alliance of Genome Resources:
Additional Orthologs for SNORD21

Paralogs for SNORD21 Gene

No data available for Paralogs for SNORD21 Gene

Variants for SNORD21 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SNORD21 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SNORD21 Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV deletion 23290073
nsv1008602 CNV gain 25217958
nsv508393 CNV deletion 20534489
nsv946078 CNV duplication 23825009

Additional Variant Information for SNORD21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORD21
Leiden Open Variation Database (LOVD)
SNORD21

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SNORD21 Gene

Disorders for SNORD21 Gene

Additional Disease Information for SNORD21

No disorders were found for SNORD21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNORD21 Gene

Publications for SNORD21 Gene

  1. U21, a novel small nucleolar RNA with a 13 nt. complementarity to 28S rRNA, is encoded in an intron of ribosomal protein L5 gene in chicken and mammals. (PMID: 7937132) Qu LH … Bachellerie JP (Nucleic acids research 1994) 2 3
  2. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. (PMID: 24625528) Moon S … Kim Y (Scientific reports 2014) 3
  3. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B … Wang LS (Journal of proteome research 2012) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3
  5. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G … Montanini B (Genomics 2009) 3

Products for SNORD21 Gene

Sources for SNORD21 Gene