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Aliases for SNORD118 Gene

Subcategory (RNA class) for SNORD118 Gene

snoRNA

Quality Score for this RNA gene is

13

Aliases for SNORD118 Gene

  • Small Nucleolar RNA, C/D Box 118 2 3 5
  • LCC 3
  • U8 3

External Ids for SNORD118 Gene

ORGUL Members for SNORD118 Gene

Previous GeneCards Identifiers for SNORD118 Gene

  • GC17U900626
  • GC17M008078
  • GC17M008079
  • GC17M008081
  • GC17M008083
  • GC17M008088
  • GC17M008114
  • GC17M008189
  • GC17M008238
  • GC17M008274
  • GC17M008300
  • GC17M008338
  • GC17M008367
  • GC17M008408
  • GC17M008440
  • GC17M008477

Summaries for SNORD118 Gene

GeneCards Summary for SNORD118 Gene

SNORD118 (Small Nucleolar RNA, C/D Box 118) is an RNA Gene, and is affiliated with the snoRNA class. Diseases associated with SNORD118 include Leukoencephalopathy, Brain Calcifications, And Cysts and Orofaciodigital Syndrome Xvi.

Additional gene information for SNORD118 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNORD118 Gene

Genomics for SNORD118 Gene

GeneHancer (GH) Regulatory Elements for SNORD118 Gene

Promoters and enhancers for SNORD118 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J008172 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 650.7 -1.4 -1379 5.2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF416 VAMP2 LOC105371520 TMEM107 SNORD118 GC17M008543 DVL2 CNTROB CTC1 WRAP53 POLR2A
GH17J008117 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.7 +52.3 52321 7.7 CLOCK FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZFP41 SSRP1 HES7 ALOXE3 GC17M008546 TRL-TAG1-1 TRQ-CTG1-5 TRR-TCT2-1 NEURL4 SENP3 CTC1 SNORD10
GH17J008126 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 12.4 +47.0 46998 2.1 HDGF ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF213 ZNF207 ZNF143 FOS HES7 LOC105376799 TRG-GCC2-6 PIR51497 NEURL4 SENP3 DVL2 PFAS ENSG00000265749 LOC100996842
GH17J008199 Enhancer 1.2 Ensembl ENCODE 11.6 -26.8 -26754 1.6 HDGF ZNF133 SIN3A ZNF2 YY1 ZNF121 POLR2B GLIS2 ZNF213 E2F8 ENSG00000271002 LINC00324 TMEM107 SNORD118 CTC1 PFAS GC17P008261
GH17J008195 Enhancer 1.1 Ensembl ENCODE 11.6 -22.6 -22623 1.1 HDGF PKNOX1 RB1 STAT5A YBX1 BATF KLF5 IRF4 RAD21 THRB LINC00324 SNORD118 VAMP2 ENSG00000271002 BORCS6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SNORD118 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SNORD118 Gene

Genomic Locations for SNORD118 Gene
chr17:8,173,453-8,173,588
(GRCh38/hg38)
Size:
136 bases
Orientation:
Minus strand
chr17:8,076,771-8,076,906
(GRCh37/hg19)
Size:
136 bases
Orientation:
Minus strand

Genomic View for SNORD118 Gene

Genes around SNORD118 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORD118 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORD118 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORD118 Gene

Proteins for SNORD118 Gene

Post-translational modifications for SNORD118 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORD118 Gene

Domains & Families for SNORD118 Gene

Gene Families for SNORD118 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORD118: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORD118 Gene

Function for SNORD118 Gene

Phenotypes From GWAS Catalog for SNORD118 Gene

Human Phenotype Ontology for SNORD118 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORD118 Gene

Localization for SNORD118 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SNORD118 Gene

Pathways & Interactions for SNORD118 Gene

SuperPathways for SNORD118 Gene

No Data Available

Interacting Proteins for SNORD118 Gene

Gene Ontology (GO) - Biological Process for SNORD118 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SNORD118 Gene

Drugs & Compounds for SNORD118 Gene

No Compound Related Data Available

Transcripts for SNORD118 Gene

mRNA/cDNA for SNORD118 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(24) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNORD118 Gene

No ASD Table

Relevant External Links for SNORD118 Gene

GeneLoc Exon Structure for
SNORD118
ECgene alternative splicing isoforms for
SNORD118

Expression for SNORD118 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNORD118 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNORD118 Gene:

SNORD118
genes like me logo Genes that share expression patterns with SNORD118: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORD118 Gene

Orthologs for SNORD118 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORD118 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia U8 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia U8 34
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia U8 34
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm25369 34
  • 65 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia U8 34
  • 63 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea U8 34
  • 52 (a)
OneToMany
Species where no ortholog for SNORD118 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SNORD118 Gene

ENSEMBL:
Gene Tree for SNORD118 (if available)
TreeFam:
Gene Tree for SNORD118 (if available)

Paralogs for SNORD118 Gene

No data available for Paralogs for SNORD118 Gene

Variants for SNORD118 Gene

Sequence variations from dbSNP and Humsavar for SNORD118 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs201787275 pathogenic, Leukoencephalopathy, brain calcifications, and cysts 8,173,444(-) G/A/C downstream_transcript_variant
rs75008470 pathogenic, Leukoencephalopathy, brain calcifications, and cysts 8,173,448(-) G/A/C/T downstream_transcript_variant
rs752171066 pathogenic, Orofaciodigital syndromes, JOUBERT SYNDROME 29, OROFACIODIGITAL SYNDROME XVI 8,174,573(-) GAAGAAG/GAAG upstream_transcript_variant
rs755495846 pathogenic, Leukoencephalopathy, brain calcifications, and cysts 8,173,531(-) T/A/C/G non_coding_transcript_variant
rs886039783 pathogenic, Leukoencephalopathy, brain calcifications, and cysts 8,173,637(-) AAGCTA/ upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNORD118 Gene

Variant ID Type Subtype PubMed ID
nsv833353 CNV loss 17160897
nsv833352 CNV loss 17160897
nsv827879 CNV gain 20364138
nsv527475 CNV loss 19592680
nsv1964 CNV insertion 18451855

Additional Variant Information for SNORD118 Gene

Human Gene Mutation Database (HGMD)
SNORD118
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORD118

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORD118 Gene

Disorders for SNORD118 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SNORD118 Gene - From: HGMD, OMIM, ClinVar, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SNORD118

genes like me logo Genes that share disorders with SNORD118: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNORD118 Gene

Publications for SNORD118 Gene

  1. U3, U8 and U13 comprise a new class of mammalian snRNPs localized in the cell nucleolus. (PMID: 2531075) Tyc K … Steitz JA (The EMBO journal 1989) 2 3 58
  2. Primary and secondary structure of U8 small nuclear RNA. (PMID: 2411727) Reddy R … Busch H (The Journal of biological chemistry 1985) 2 3 58
  3. Leukoencephalopathy with calcification and cysts: A cerebral microangiopathy caused by mutations in SNORD118. (PMID: 27793341) Livingston JH … Crow YJ (Journal of the neurological sciences 2017) 3 58
  4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  5. Identification of novel SNORD118 mutations in seven patients with leukoencephalopathy with brain calcifications and cysts. (PMID: 28177126) Iwama K … Matsumoto N (Clinical genetics 2017) 3 58

Products for SNORD118 Gene

Sources for SNORD118 Gene

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