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Aliases for SNORD115-37 Gene

Subcategory (RNA class) for SNORD115-37 Gene


Quality Score for this RNA gene is


Aliases for SNORD115-37 Gene

  • Small Nucleolar RNA, C/D Box 115-37 2 3 5
  • HBII-52-37 3

External Ids for SNORD115-37 Gene

Previous GeneCards Identifiers for SNORD115-37 Gene

  • GC15U900739
  • GC15P023488
  • GC15P023561
  • GC15P023656
  • GC15P025483
  • GC15P003607
  • GC15P025263
  • GC15P025311
  • GC15P025527
  • GC15P025561
  • GC15P025632
  • GC15P025675
  • GC15P025755

Summaries for SNORD115-37 Gene

GeneCards Summary for SNORD115-37 Gene

SNORD115-37 (Small Nucleolar RNA, C/D Box 115-37) is an RNA Gene, and is affiliated with the snoRNA class. Diseases associated with SNORD115-37 include Prader-Willi Syndrome.

fRNAdb sequence ontologies for SNORD115-37 Gene - the ORGUL cluster for this gene includes several descriptions:

  • C_D_box_snoRNA: Most box C/D snoRNAs also contain long (>10 nt) sequences complementary to rRNA. Boxes C and D, as well as boxes C' and D', are usually located in close proximity, and form a structure known as the box C/D motif. This motif is important for snoRNA stability, processing, nucleolar targeting and function. A small number of box C/D snoRNAs are involved in rRNA processing; most, however, are known or predicted to serve as guide RNAs in ribose methylation of rRNA. Targeting involves direct base pairing of the snoRNA at the rRNA site to be modified and selection of a rRNA nucleotide a fixed distance from box D or D'.

  • Small nucleolar RNA SNORD115: HBII-52 is a member of the C/D class of snoRNAs, which contain the C (UGAUGA) and D (CUGA) box motifs. HBII-52 is encoded in a tandemly repeated array with another C/D snoRNA, HBII-85, in the Prader-Willi syndrome (PWS) region of chromosome 15. HBII-52 is exclusively expressed in the brain but is absent in PWS patients. HBII-52 lacks any significant complementarity with ribosomal RNAs, but does have an 18-nt region of conserved complementarity to serotonin 2C receptor mRNA.

View fRNAdb secondary structures for SNORD115-37

Additional gene information for SNORD115-37 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORD115-37 Gene

Genomics for SNORD115-37 Gene

GeneHancer (GH) Regulatory Elements for SNORD115-37 Gene

Top Transcription factor binding sites by QIAGEN in the SNORD115-37 gene promoter:

Genomic Locations for SNORD115-37 Gene

Genomic Locations for SNORD115-37 Gene
82 bases
Plus strand

Genomic View for SNORD115-37 Gene

Genes around SNORD115-37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORD115-37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORD115-37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORD115-37 Gene

ORGUL Member Location for SNORD115-37 Gene

ORGUL Member Location for SNORD115-37 gene

Proteins for SNORD115-37 Gene

Post-translational modifications for SNORD115-37 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORD115-37 Gene

Domains & Families for SNORD115-37 Gene

Gene Families for SNORD115-37 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORD115-37: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORD115-37 Gene

Function for SNORD115-37 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORD115-37 Gene

Localization for SNORD115-37 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SNORD115-37 Gene

Pathways & Interactions for SNORD115-37 Gene

SuperPathways for SNORD115-37 Gene

No Data Available

Interacting Proteins for SNORD115-37 Gene

Gene Ontology (GO) - Biological Process for SNORD115-37 Gene


No data available for Pathways by source and SIGNOR curated interactions for SNORD115-37 Gene

Drugs & Compounds for SNORD115-37 Gene

No Compound Related Data Available

Transcripts for SNORD115-37 Gene

fRNAdb Secondary structures for SNORD115-37 Gene

  • RF00105;SNORD115;AEKP01177458.1/5653-5572

mRNA/cDNA for SNORD115-37 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNORD115-37 Gene

No ASD Table

Relevant External Links for SNORD115-37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNORD115-37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNORD115-37 Gene

genes like me logo Genes that share expression patterns with SNORD115-37: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORD115-37 Gene

Orthologs for SNORD115-37 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SNORD115-37 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNORD115 34
  • 100 (a)
Species where no ortholog for SNORD115-37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SNORD115-37 Gene

Gene Tree for SNORD115-37 (if available)
Gene Tree for SNORD115-37 (if available)

Paralogs for SNORD115-37 Gene

No data available for Paralogs for SNORD115-37 Gene

Variants for SNORD115-37 Gene

Sequence variations from dbSNP and Humsavar for SNORD115-37 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000081225 -- 25,236,583(+) T/G upstream_transcript_variant
rs1003999253 -- 25,238,181(+) A/G downstream_transcript_variant
rs1004451812 -- 25,237,192(+) A/G upstream_transcript_variant
rs1004502060 -- 25,236,946(+) G/A upstream_transcript_variant
rs1005919370 -- 25,237,824(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNORD115-37 Gene

Variant ID Type Subtype PubMed ID
dgv2478n100 CNV gain 25217958
dgv2479n100 CNV gain 25217958
dgv2483n100 CNV gain+loss 25217958
dgv2485n100 CNV loss 25217958
dgv2486n100 CNV gain 25217958
dgv4390n54 CNV loss 21841781
esv25915 CNV gain+loss 19812545
esv2761832 CNV gain+loss 21179565
esv33464 CNV gain 17666407
esv3569320 CNV gain 25503493
nsv1053030 CNV loss 25217958
nsv1467 CNV deletion 18451855
nsv517360 CNV gain+loss 19592680
nsv952576 CNV deletion 24416366
nsv976898 CNV duplication 23825009

Additional Variant Information for SNORD115-37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORD115-37 Gene

Disorders for SNORD115-37 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SNORD115-37 Gene - From: GeneCards

Disorder Aliases PubMed IDs
prader-willi syndrome
  • pws
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SNORD115-37

genes like me logo Genes that share disorders with SNORD115-37: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNORD115-37 Gene

Publications for SNORD115-37 Gene

  1. The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A. (PMID: 11726556) Runte M … Buiting K (Human molecular genetics 2001) 1 2 3 58
  2. Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization. (PMID: 11106375) Cavaillé J … Hüttenhofer A (Proceedings of the National Academy of Sciences of the United States of America 2000) 1 2 3 58
  3. The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C. (PMID: 16357227) Kishore S … Stamm S (Science (New York, N.Y.) 2006) 1 3 58
  4. Exclusion of the C/D box snoRNA gene cluster HBII-52 from a major role in Prader-Willi syndrome. (PMID: 15565282) Runte M … Buiting K (Human genetics 2005) 1 3 58
  5. ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs. (PMID: 15939761) Vitali P … Huttenhofer A (The Journal of cell biology 2005) 1 3 58

Products for SNORD115-37 Gene

Sources for SNORD115-37 Gene

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