Small nucleolar RNAs (snoRNAs) are small noncoding RNAs involved in RNA processing. Box H/ACA snoRNAs, such as SNORA74B, direct the conversion of uridine to pseudouridine at specific residues of ribosomal RNAs or small nuclear RNAs (snRNAs) (Gu et al., 2005).[supplied by OMIM, Mar 2008] See more...

Aliases for SNORA74B Gene

Subcategory (RNA class) for SNORA74B Gene

snoRNA

Quality Score for this RNA gene is

17

Aliases for SNORA74B Gene

  • Small Nucleolar RNA, H/ACA Box 74B 2 3 5
  • SNORA74B 2 176
  • NONHSAG042253 94
  • U19-2 SnoRNA 3
  • Lnc-CREBRF-1 170
  • RF00090 174
  • U19-2 3

External Ids for SNORA74B Gene

Previous GeneCards Identifiers for SNORA74B Gene

  • GC05P172381
  • GC05P167542
  • GC05P172447

Summaries for SNORA74B Gene

Entrez Gene Summary for SNORA74B Gene

  • Small nucleolar RNAs (snoRNAs) are small noncoding RNAs involved in RNA processing. Box H/ACA snoRNAs, such as SNORA74B, direct the conversion of uridine to pseudouridine at specific residues of ribosomal RNAs or small nuclear RNAs (snRNAs) (Gu et al., 2005).[supplied by OMIM, Mar 2008]

GeneCards Summary for SNORA74B Gene

SNORA74B (Small Nucleolar RNA, H/ACA Box 74B) is an RNA Gene, and is affiliated with the snoRNA class.

Rfam classification for SNORA74B Gene

  • Small nucleolar RNA SNORA74

Additional gene information for SNORA74B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORA74B Gene

Genomics for SNORA74B Gene

GeneHancer (GH) Regulatory Elements for SNORA74B Gene

Promoters and enhancers for SNORA74B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNORA74B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNORA74B gene promoter:
  • Bach1
  • Cart-1
  • FOXI1
  • FOXJ2 (long isoform)
  • HFH-3
  • ISGF-3
  • Nkx6-1
  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha2

Genomic Locations for SNORA74B Gene

Genomic Locations for SNORA74B Gene
chr5:173,020,726-173,020,929
(GRCh38/hg38)
Size:
204 bases
Orientation:
Plus strand
chr5:172,447,729-172,447,932
(GRCh37/hg19)
Size:
204 bases
Orientation:
Plus strand

Genomic View for SNORA74B Gene

Genes around SNORA74B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORA74B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORA74B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORA74B Gene

Proteins for SNORA74B Gene

Post-translational modifications for SNORA74B Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORA74B Gene

Domains & Families for SNORA74B Gene

Gene Families for SNORA74B Gene

genes like me logo Genes that share domains with SNORA74B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SNORA74B Gene

Function for SNORA74B Gene

Phenotypes From GWAS Catalog for SNORA74B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORA74B Gene

Localization for SNORA74B Gene

Gene Ontology (GO) - Cellular Components for SNORA74B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with SNORA74B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SNORA74B Gene

Pathways & Interactions for SNORA74B Gene

PathCards logo

SuperPathways for SNORA74B Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNORA74B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with SNORA74B: view

No data available for Pathways by source and SIGNOR curated interactions for SNORA74B Gene

Drugs & Compounds for SNORA74B Gene

No Compound Related Data Available

Transcripts for SNORA74B Gene

mRNA/cDNA for SNORA74B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(1) NONCODE transcripts :
(2) RNACentral transcripts :
(1) ENA transcripts :
(1) LNCipedia transcripts :
(1) Rfam transcripts :
(1) snOPY transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNORA74B Gene

No ASD Table

Relevant External Links for SNORA74B Gene

GeneLoc Exon Structure for
SNORA74B
ECgene alternative splicing isoforms for
SNORA74B

Expression for SNORA74B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNORA74B Gene

NURSA nuclear receptor signaling pathways regulating expression of SNORA74B Gene:

SNORA74B

SOURCE GeneReport for Unigene cluster for SNORA74B Gene:

Hs.692720
genes like me logo Genes that share expression patterns with SNORA74B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORA74B Gene

Orthologs for SNORA74B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORA74B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNORA74 33
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm23946 33
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SNORA74 33
  • 78 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SNORA74 33
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SNORA74 33
  • 63 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SNORA74 33 33
  • 62 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SNORA74 33
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia SNORA74 33 33
  • 61 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii SNORA74 33
  • 55 (a)
OneToMany
Species where no ortholog for SNORA74B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNORA74B Gene

ENSEMBL:
Gene Tree for SNORA74B (if available)
TreeFam:
Gene Tree for SNORA74B (if available)

Paralogs for SNORA74B Gene

No data available for Paralogs for SNORA74B Gene

Variants for SNORA74B Gene

Sequence variations from dbSNP and Humsavar for SNORA74B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1004436151 -- 173,019,375(+) G/A upstream_transcript_variant
rs1004830244 -- 173,019,196(+) T/C upstream_transcript_variant
rs1011473336 -- 173,019,923(+) G/A upstream_transcript_variant
rs1012526709 -- 173,021,123(+) A/G downstream_transcript_variant
rs1012899696 -- 173,019,154(+) C/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNORA74B Gene

Variant ID Type Subtype PubMed ID
nsv830555 CNV loss 17160897

Additional Variant Information for SNORA74B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORA74B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORA74B Gene

Disorders for SNORA74B Gene

Additional Disease Information for SNORA74B

No disorders were found for SNORA74B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNORA74B Gene

Publications for SNORA74B Gene

  1. snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. (PMID: 16381836) Lestrade L … Weber MJ (Nucleic acids research 2006) 2 3 56
  2. A novel experimental approach for systematic identification of box H/ACA snoRNAs from eukaryotes. (PMID: 16361266) Gu AD … Qu LH (Nucleic acids research 2005) 2 3 56
  3. Human box H/ACA pseudouridylation guide RNA machinery. (PMID: 15199136) Kiss AM … Kiss T (Molecular and cellular biology 2004) 2 3 56
  4. SNORA74B gene silencing inhibits gallbladder cancer cells by inducing PHLPP and suppressing Akt/mTOR signaling. (PMID: 28212545) Qin Y … Han K (Oncotarget 2017) 3 56
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 56

Products for SNORA74B Gene

Sources for SNORA74B Gene