This gene encodes a non-coding RNA that functions in the biogenesis of other small nuclear RNAs. This RNA is found in the nucleolus, where it may be involved in the pseudouridylation of 18S ribosomal RNA. This RNA is found associated with the GAR1 protein. [provided by RefSeq, Apr 2009] See more...

Aliases for SNORA66 Gene

Data sources for SNORA66 Gene:

RNA type for SNORA66 Gene

snoRNA

Aliases for SNORA66 Gene

External Ids for SNORA66 Gene

Previous HGNC Symbols for SNORA66 Gene

  • RNU66

Previous GeneCards Identifiers for SNORA66 Gene

  • GC01P093078
  • GC01P093306
  • GC01P091427

Summaries for SNORA66 Gene

Entrez Gene Summary for SNORA66 Gene

  • This gene encodes a non-coding RNA that functions in the biogenesis of other small nuclear RNAs. This RNA is found in the nucleolus, where it may be involved in the pseudouridylation of 18S ribosomal RNA. This RNA is found associated with the GAR1 protein. [provided by RefSeq, Apr 2009]

GeneCards Summary for SNORA66 Gene

SNORA66 (Small Nucleolar RNA, H/ACA Box 66) is an RNA Gene, and is affiliated with the snoRNA class. Diseases associated with SNORA66 include Retroperitoneal Neuroblastoma and Diamond-Blackfan Anemia.

Rfam classification for SNORA66 Gene

  • Small nucleolar RNA SNORA66

Additional gene information for SNORA66 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORA66 Gene

Genomics for SNORA66 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SNORA66 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNORA66 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the SNORA66 gene promoter:
  • AML1a
  • AREB6
  • C/EBPalpha
  • Elk-1
  • HSF2
  • MyoD
  • PPAR-gamma1
  • PPAR-gamma2
  • Sox9

Genomic Locations for SNORA66 Gene

Latest Assembly
chr1:92,840,719-92,840,851
(GRCh38/hg38)
Size:
133 bases
Orientation:
Plus strand

Previous Assembly
chr1:93,306,276-93,306,408
(GRCh37/hg19 by Entrez Gene)
Size:
133 bases
Orientation:
Plus strand

chr1:93,306,276-93,306,408
(GRCh37/hg19 by Ensembl)
Size:
133 bases
Orientation:
Plus strand

Genomic View for SNORA66 Gene

Genes around SNORA66 on UCSC Golden Path with GeneCards custom track
SNORA66 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
SNORA66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORA66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORA66 Gene

Proteins for SNORA66 Gene

Post-translational modifications for SNORA66 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORA66 Gene

Domains & Families for SNORA66 Gene

Gene Families for SNORA66 Gene

genes like me logo Genes that share domains with SNORA66: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SNORA66 Gene

Function for SNORA66 Gene

Phenotypes From GWAS Catalog for SNORA66 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORA66 Gene

Localization for SNORA66 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNORA66 gene
Compartment Confidence
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SNORA66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with SNORA66: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SNORA66 Gene

Pathways & Interactions for SNORA66 Gene

PathCards logo

SuperPathways for SNORA66 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNORA66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with SNORA66: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for SNORA66 Gene

Drugs & Compounds for SNORA66 Gene

No Compound Related Data Available

Transcripts for SNORA66 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for SNORA66 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000656AFD_9606 snoRNA 133 5

RefSeq: NR_002444,

Ensembl: ENST00000384792 (view in UCSC) ,

Rfam: RF00155,

snoDB: SNODB468,

snOPY: Homo_sapiens300670,

URS00003F0D62_9606 snoRNA 133 1

ENA: AB061848.1:169..301:ncRNA, Y11160.1:1..133:ncRNA,

URS0001BC3945_9606 snoRNA 133 1

Rfam: RF00155,

URS0001BC601B_9606 snoRNA 133 1

Rfam: RF00155,

URS0001BBF5F0_9606 snoRNA 130 1

Rfam: RF00155,

SNORA66 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for SNORA66 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for SNORA66 Gene

No ASD Table

Relevant External Links for SNORA66 Gene

GeneLoc Exon Structure for
SNORA66

Expression for SNORA66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNORA66 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SNORA66

genes like me logo Genes that share expression patterns with SNORA66: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORA66 Gene

Orthologs for SNORA66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORA66 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SNORA66 30
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia SNORA66 30
  • 86 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm26387 30
  • 82 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia SNORA66 30
  • 82 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SNORA66 30
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SNORA66 30
  • 70 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves SNORA66 30
  • 52 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia SNORA66 30
  • 72 (a)
OneToMany
Species where no ortholog for SNORA66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SNORA66 Gene

ENSEMBL:
Gene Tree for SNORA66 (if available)
TreeFam:
Gene Tree for SNORA66 (if available)
Alliance of Genome Resources:
Additional Orthologs for SNORA66

Paralogs for SNORA66 Gene

No data available for Paralogs for SNORA66 Gene

Variants for SNORA66 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SNORA66 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs10874744 Benign: Diamond-Blackfan anemia 92,840,760(+) G/A
NM_000969.5(RPL5):c.794+121G>A
NON_CODING_TRANSCRIPT_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SNORA66 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SNORA66 Gene

Variant ID Type Subtype PubMed ID
esv2714684 CNV deletion 23290073
nsv1008602 CNV gain 25217958
nsv508393 CNV deletion 20534489

Additional Variant Information for SNORA66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNORA66
Leiden Open Variation Database (LOVD)
SNORA66

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORA66 Gene

Disorders for SNORA66 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SNORA66 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
retroperitoneal neuroblastoma
diamond-blackfan anemia
  • blackfan - diamond syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SNORA66

genes like me logo Genes that share disorders with SNORA66: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNORA66 Gene

Publications for SNORA66 Gene

  1. snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. (PMID: 16381836) Lestrade L … Weber MJ (Nucleic acids research 2006) 2 3
  2. Human box H/ACA pseudouridylation guide RNA machinery. (PMID: 15199136) Kiss AM … Kiss T (Molecular and cellular biology 2004) 2 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3
  4. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G … Montanini B (Genomics 2009) 3

Products for SNORA66 Gene

Sources for SNORA66 Gene