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Aliases for SNORA2B Gene

Subcategory (RNA class) for SNORA2B Gene


Quality Score for this RNA gene is


Aliases for SNORA2B Gene

  • Small Nucleolar RNA, H/ACA Box 2B 2 3 5
  • ACA2b SnoRNA 3
  • ACA2b 3

External Ids for SNORA2B Gene

Previous GeneCards Identifiers for SNORA2B Gene

  • GC12M047349
  • GC12M049061
  • GC12M046095

Summaries for SNORA2B Gene

GeneCards Summary for SNORA2B Gene

SNORA2B (Small Nucleolar RNA, H/ACA Box 2B) is an RNA Gene, and is affiliated with the snoRNA class.

fRNAdb sequence ontologies for SNORA2B Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • H_ACA_box_snoRNA: Members of the box H/ACA family contain an ACA triplet, exactly 3 nt upstream from the 3' end and an H-box in a hinge region that links two structurally similar functional domains of the molecule. Both boxes are important for snoRNA biosynthesis and function. A few box H/ACA snoRNAs are involved in rRNA processing; most others are known or predicted to participate in selection of uridine nucleosides in rRNA to be converted to pseudouridines. Site selection is mediated by direct base pairing of the snoRNA with rRNA through one or both targeting domains.

  • Small nucleolar RNA SNORA2/SNORA34 family: The members of this family belong to the H/ACA class of snoRNAs which are predicted to guide the sites of modification of uridines to pseudouridines [1]. This family includes human snoRNAs ACA2a (SNORA2A), ACA2b (SNORA2B) and ACA34 (SNORA34). ACA2a and ACA2a are predicted to guide pseudouridylation of U4263 and U4282 in 28S rRNA and ACA34 is predicted to guide the pseudouridylation of residue U4269 and U4282 of 28S rRNA [2]. In humans all three of these snoRNAs share the same host gene [2].

View fRNAdb secondary structures for SNORA2B

Additional gene information for SNORA2B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNORA2B Gene

Genomics for SNORA2B Gene

GeneHancer (GH) Regulatory Elements for SNORA2B Gene

Promoters and enhancers for SNORA2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J048681 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 0.4 -14.4 -14408 2.8 MTA3 CC2D1A SP1 ELF3 ZFX NKRF POLR2A MLLT1 ZNF121 GTF2F1 KANSL2 SENP1 CCNT1 RPAP3 DDX23 KMT2D FAM186B LMBR1L ENSG00000257964 PRPF40B
GH12J048677 Promoter 0.9 Ensembl 0.4 -11.4 -11408 2.8 ZNF121 ZSCAN21 PRDM1 ZNF600 CEBPB ZBTB11 ZNF189 ZFP69B BCOR ZNF324 KANSL2 SNORA2C GC12M048339 GC12M048675 SNORA2B
GH12J048671 Enhancer 0.3 ENCODE 0.7 -3.8 -3840 0.2 POLR2A SNORA2B GC12M048675 KANSL2 GC12M048339
GH12J048672 Enhancer 0.3 ENCODE 0.7 -4.1 -4100 0.2 POLR2A SNORA2B GC12M048675 KANSL2 GC12M048339
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNORA2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNORA2B gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5

Genomic Locations for SNORA2B Gene

Genomic Locations for SNORA2B Gene
137 bases
Minus strand
137 bases
Minus strand

Genomic View for SNORA2B Gene

Genes around SNORA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNORA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNORA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNORA2B Gene

ORGUL Member Location for SNORA2B Gene

ORGUL Member Location for SNORA2B gene

Proteins for SNORA2B Gene

Post-translational modifications for SNORA2B Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNORA2B Gene

Domains & Families for SNORA2B Gene

Gene Families for SNORA2B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SNORA2B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SNORA2B Gene

Function for SNORA2B Gene

Phenotypes From GWAS Catalog for SNORA2B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNORA2B Gene

Localization for SNORA2B Gene

Gene Ontology (GO) - Cellular Components for SNORA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with SNORA2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SNORA2B Gene

Pathways & Interactions for SNORA2B Gene

PathCards logo

SuperPathways for SNORA2B Gene

No Data Available

Interacting Proteins for SNORA2B Gene

Gene Ontology (GO) - Biological Process for SNORA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with SNORA2B: view

No data available for Pathways by source and SIGNOR curated interactions for SNORA2B Gene

Drugs & Compounds for SNORA2B Gene

No Compound Related Data Available

Transcripts for SNORA2B Gene

fRNAdb Secondary structures for SNORA2B Gene

  • FR209736

mRNA/cDNA for SNORA2B Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(1) RNA Central transcripts :

Unigene Clusters for SNORA2B Gene

Small nucleolar RNA, H/ACA box 2B:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNORA2B Gene

No ASD Table

Relevant External Links for SNORA2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNORA2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNORA2B Gene

NURSA nuclear receptor signaling pathways regulating expression of SNORA2B Gene:


SOURCE GeneReport for Unigene cluster for SNORA2B Gene:

genes like me logo Genes that share expression patterns with SNORA2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNORA2B Gene

Orthologs for SNORA2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNORA2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SNORA2 35
  • 100 (a)
(Canis familiaris)
Mammalia SNORA2 35
  • 96 (a)
(Bos Taurus)
Mammalia SNORA2 35 35 35
  • 94 (a)
(Mus musculus)
Mammalia Snora2b 35
  • 93 (a)
(Monodelphis domestica)
Mammalia SNORA2 35
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia SNORA2 35
  • 66 (a)
(Gallus gallus)
Aves SNORA2 35
  • 58 (a)
(Anolis carolinensis)
Reptilia SNORA2 35
  • 69 (a)
(Danio rerio)
Actinopterygii SNORA2 35
  • 67 (a)
Species where no ortholog for SNORA2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNORA2B Gene

Gene Tree for SNORA2B (if available)
Gene Tree for SNORA2B (if available)

Paralogs for SNORA2B Gene

No data available for Paralogs for SNORA2B Gene

Variants for SNORA2B Gene

Sequence variations from dbSNP and Humsavar for SNORA2B Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000294553 -- 48,669,038(-) C/T upstream_transcript_variant
rs1001388938 -- 48,667,181(-) T/C downstream_transcript_variant
rs1002390353 -- 48,668,634(-) T/C upstream_transcript_variant
rs1003133726 -- 48,667,177(-) T/A downstream_transcript_variant
rs1003446019 -- 48,669,480(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNORA2B Gene

Variant ID Type Subtype PubMed ID
dgv1496n100 CNV gain 25217958
nsv438209 CNV loss 16468122

Additional Variant Information for SNORA2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNORA2B Gene

Disorders for SNORA2B Gene

Additional Disease Information for SNORA2B

No disorders were found for SNORA2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNORA2B Gene

Publications for SNORA2B Gene

  1. snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. (PMID: 16381836) Lestrade L … Weber MJ (Nucleic acids research 2006) 1 2 3 58
  2. Human box H/ACA pseudouridylation guide RNA machinery. (PMID: 15199136) Kiss AM … Kiss T (Molecular and cellular biology 2004) 1 2 3 58
  3. Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. (PMID: 25187353) Goldstein JI … Sullivan PF (Nature communications 2014) 3 58
  4. Eukaryotic snoRNAs: a paradigm for gene expression flexibility. (PMID: 19446021) Dieci G … Montanini B (Genomics 2009) 3 58
  5. The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. (PMID: 18089548) Genome Information Integration Project And H-Invitational 2 … Gojobori T (Nucleic acids research 2008) 1

Products for SNORA2B Gene

Sources for SNORA2B Gene

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