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Aliases for SNN Gene

Aliases for SNN Gene

External Ids for SNN Gene

Previous GeneCards Identifiers for SNN Gene

  • GC16P011545
  • GC16P011914
  • GC16P011728

Summaries for SNN Gene

GeneCards Summary for SNN Gene

SNN (Stannin) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SNN Gene

  • Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288).

Gene Wiki entry for SNN Gene

Additional gene information for SNN Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNN Gene

Genomics for SNN Gene

GeneHancer (GH) Regulatory Elements for SNN Gene

Promoters and enhancers for SNN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J011667 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 663.5 +2.0 1979 6.7 IRF4 ZNF48 GLIS2 ZNF143 ATF7 FOS RUNX3 SP5 NFYC MXD4 SNN ZC3H7A TXNDC11 LITAF LOC105371084 ENSG00000261560 HNRNPCP4 RSL1D1 COX6CP1 SNX29
GH16J011639 Enhancer 2 VISTA FANTOM5 Ensembl ENCODE dbSUPER 13.8 -27.8 -27756 3.3 PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A YBX1 DMAP1 ZNF2 YY1 SLC30A9 LITAF LOC105371084 HNRNPCP4 ENSG00000261560 COX6CP1 ZC3H7A TNP2 ENSG00000261216 TXNDC11 ENSG00000262020
GH16J011580 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.7 -84.1 -84078 7.7 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B LITAF TVP23A TXNDC11 SNN ZC3H7A SNX29 SOCS1 LOC400499
GH16J011790 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7 +127.5 127488 10.1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC SSRP1 ZC3H7A GC16P011798 ENSG00000277369 NPIPB2 TNP2 ENSG00000262020 ENSG00000261293 ENSG00000199668 PRM3 ENSG00000212228
GH16J011595 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11 -71.2 -71213 4.4 ELF3 HDGF PTBP1 PKNOX1 ZFP64 YBX1 NFXL1 DNMT3B RFX5 RARA LITAF SNN TXNDC11 SOCS1 ZC3H7A SNX29 LOC400499
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNN gene promoter:
  • p53
  • NF-kappaB1
  • NF-kappaB
  • Nkx2-5
  • N-Myc
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for SNN Gene

Genomic Locations for SNN Gene
10,746 bases
Plus strand
10,746 bases
Plus strand

Genomic View for SNN Gene

Genes around SNN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNN Gene

Proteins for SNN Gene

  • Protein details for SNN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DUG4
    • Q6FGI0

    Protein attributes for SNN Gene

    88 amino acids
    Molecular mass:
    9497 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for SNN Gene

neXtProt entry for SNN Gene

Post-translational modifications for SNN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNN Gene

Domains & Families for SNN Gene

Gene Families for SNN Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SNN Gene

Suggested Antigen Peptide Sequences for SNN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the stannin family.
  • Belongs to the stannin family.
genes like me logo Genes that share domains with SNN: view

Function for SNN Gene

Molecular function for SNN Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288).
GENATLAS Biochemistry:
stannin,involved in the toxic effect of organotins

Phenotypes From GWAS Catalog for SNN Gene

Gene Ontology (GO) - Molecular Function for SNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IDA 16246365
genes like me logo Genes that share ontologies with SNN: view
genes like me logo Genes that share phenotypes with SNN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNN Gene

Localization for SNN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNN Gene

Mitochondrion outer membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNN gene
Compartment Confidence
extracellular 3
mitochondrion 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16246365
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA 16246365
genes like me logo Genes that share ontologies with SNN: view

Pathways & Interactions for SNN Gene

No Data Available

Interacting Proteins for SNN Gene

Gene Ontology (GO) - Biological Process for SNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009636 response to toxic substance TAS 16246365
genes like me logo Genes that share ontologies with SNN: view

No data available for Pathways by source and SIGNOR curated interactions for SNN Gene

Drugs & Compounds for SNN Gene

(3) Additional Compounds for SNN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SNN: view

Transcripts for SNN Gene

mRNA/cDNA for SNN Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(197) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SNN Gene

Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNN

Alternative Splicing Database (ASD) splice patterns (SP) for SNN Gene

No ASD Table

Relevant External Links for SNN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SNN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SNN Gene

This gene is overexpressed in Fetal Brain (59.3) and Frontal cortex (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SNN Gene

Protein tissue co-expression partners for SNN Gene

NURSA nuclear receptor signaling pathways regulating expression of SNN Gene:


SOURCE GeneReport for Unigene cluster for SNN Gene:


Evidence on tissue expression from TISSUES for SNN Gene

  • Nervous system(4.9)
  • Heart(4.3)
  • Lung(3.6)
genes like me logo Genes that share expression patterns with SNN: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNN Gene

Orthologs for SNN Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNN Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia SNN 34
  • 100 (a)
(Pan troglodytes)
Mammalia SNN 34 33
  • 100 (n)
(Ornithorhynchus anatinus)
Mammalia SNN 34
  • 97 (a)
(Bos Taurus)
Mammalia SNN 34 33
  • 93.02 (n)
(Canis familiaris)
Mammalia SNN 34 33
  • 92.72 (n)
(Rattus norvegicus)
Mammalia Snn 33
  • 89.39 (n)
(Mus musculus)
Mammalia Snn 16 34 33
  • 89.02 (n)
(Gallus gallus)
Aves SNN 34 33
  • 81.01 (n)
(Anolis carolinensis)
Reptilia SNN 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snn 33
  • 80.23 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8490 33
(Danio rerio)
Actinopterygii snn 34 33
  • 79.46 (n)
wufj47f06 33
Species where no ortholog for SNN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNN Gene

Gene Tree for SNN (if available)
Gene Tree for SNN (if available)
Evolutionary constrained regions (ECRs) for SNN: view image

Paralogs for SNN Gene

No data available for Paralogs for SNN Gene

Variants for SNN Gene

Sequence variations from dbSNP and Humsavar for SNN Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000211768 -- 11,669,608(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000531134 -- 11,670,860(+) C/A genic_upstream_transcript_variant, intron_variant
rs1001524302 -- 11,672,926(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001630298 -- 11,677,917(+) C/T 3_prime_UTR_variant
rs1001811357 -- 11,674,126(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SNN Gene

Variant ID Type Subtype PubMed ID
esv22331 CNV loss 19812545
nsv1144756 CNV deletion 24896259
nsv457409 CNV gain 19166990
nsv524676 CNV loss 19592680
nsv571456 CNV gain 21841781
nsv952922 CNV deletion 24416366

Variation tolerance for SNN Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNN Gene

Disorders for SNN Gene

Additional Disease Information for SNN

No disorders were found for SNN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SNN Gene

Publications for SNN Gene

  1. Chromosomal localization and characterization of the stannin (Snn) gene. (PMID: 9657854) Dejneka NS … Billingsley ML (Mammalian genome : official journal of the International Mammalian Genome Society 1998) 2 3 4 22 58
  2. Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride. (PMID: 16246365) Buck-Koehntop BA … Veglia G (Journal of molecular biology 2005) 3 4 22 58
  3. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PMID: 10233894) Horrevoets AJ … Pannekoek H (Blood 1999) 3 4 22 58
  4. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C … Stricker BH (Nature genetics 2009) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SNN Gene

Sources for SNN Gene

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