SNN Gene (Protein Coding)

Stannin

GC16P011669
GIFtS:
33
See more...

Aliases for SNN Gene

Aliases for SNN Gene

External Ids for SNN Gene

Previous GeneCards Identifiers for SNN Gene

  • GC16P011545
  • GC16P011914
  • GC16P011728

Summaries for SNN Gene

GeneCards Summary for SNN Gene

SNN (Stannin) is a Protein Coding gene. Diseases associated with SNN include Retinitis Pigmentosa 47 and Retinitis Pigmentosa 57.

UniProtKB/Swiss-Prot Summary for SNN Gene

  • Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288).

Gene Wiki entry for SNN Gene

Additional gene information for SNN Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SNN Gene

Genomics for SNN Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for SNN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNN on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SNN

Top Transcription factor binding sites by QIAGEN in the SNN gene promoter:
  • N-Myc
  • NF-kappaB
  • NF-kappaB1
  • Nkx2-5
  • p53
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for SNN Gene

Genomic Locations for SNN Gene
chr16:11,668,455-11,679,154
(GRCh38/hg38)
Size:
10,700 bases
Orientation:
Plus strand
chr16:11,762,270-11,773,015
(GRCh37/hg19)
Size:
10,746 bases
Orientation:
Plus strand

Genomic View for SNN Gene

Genes around SNN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNN Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SNN Gene

Proteins for SNN Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SNN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75324-SNN_HUMAN
    Recommended name:
    Stannin
    Protein Accession:
    O75324
    Secondary Accessions:
    • D3DUG4
    • Q6FGI0

    Protein attributes for SNN Gene

    Size:
    88 amino acids
    Molecular mass:
    9497 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for SNN Gene

neXtProt entry for SNN Gene

Protein Expression for SNN Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for SNN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SNN Gene

Domains & Families for SNN Gene

Gene Families for SNN Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SNN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SNN Gene

GenScript: Design optimal peptide antigens:
  • AG8_1 (SNN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75324

UniProtKB/Swiss-Prot:

SNN_HUMAN :
  • Belongs to the stannin family.
Family:
  • Belongs to the stannin family.
genes like me logo Genes that share domains with SNN: view

Function for SNN Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for SNN Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the toxic effects of organotins (PubMed:15269288). Plays a role in endosomal maturation (PubMed:27015288).
GENATLAS Biochemistry:
stannin,involved in the toxic effect of organotins

Phenotypes From GWAS Catalog for SNN Gene

Gene Ontology (GO) - Molecular Function for SNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IDA 16246365
genes like me logo Genes that share ontologies with SNN: view
genes like me logo Genes that share phenotypes with SNN: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNN Gene

Localization for SNN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNN Gene

Mitochondrion outer membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNN gene
Compartment Confidence
mitochondrion 4
extracellular 3
nucleus 2
cytosol 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16246365
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IDA 16246365
genes like me logo Genes that share ontologies with SNN: view

Pathways & Interactions for SNN Gene

PathCards logo

SuperPathways for SNN Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009636 response to toxic substance TAS 16246365
genes like me logo Genes that share ontologies with SNN: view

No data available for Pathways by source and SIGNOR curated interactions for SNN Gene

Drugs & Compounds for SNN Gene

Products:

  1. Drug

(3) Additional Compounds for SNN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SNN: view

Transcripts for SNN Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SNN Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNN

Alternative Splicing Database (ASD) splice patterns (SP) for SNN Gene

No ASD Table

Relevant External Links for SNN Gene

GeneLoc Exon Structure for
SNN

Expression for SNN Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNN Gene

mRNA expression in normal human tissues for SNN Gene
mRNA expression by GTEx for SNN GenemRNA expression by BioGPS for SNN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SNN Gene

This gene is overexpressed in Fetal Brain (59.3) and Frontal cortex (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SNN Gene



Protein tissue co-expression partners for SNN Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SNN

SOURCE GeneReport for Unigene cluster for SNN Gene:

Hs.618526

Evidence on tissue expression from TISSUES for SNN Gene

  • Nervous system(4.9)
  • Heart(4.4)
  • Lung(3.6)
  • Skin(2.6)
  • Muscle(2.6)
  • Blood(2.5)
  • Spleen(2)
genes like me logo Genes that share expression patterns with SNN: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNN Gene

Orthologs for SNN Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNN Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia SNN 30 31
  • 100 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia SNN 31
  • 100 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia SNN 31
  • 97 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia SNN 30 31
  • 93.02 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia SNN 30 31
  • 92.72 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Snn 30
  • 89.39 (n)
Mouse
(Mus musculus)
 Mammalia Snn 30 17 31
  • 89.02 (n)
 OneToOne
Chicken
(Gallus gallus)
 Aves SNN 30 31
  • 81.01 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia SNN 31
  • 78 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia snn 30
  • 80.23 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.8490 30
Zebrafish
(Danio rerio)
 Actinopterygii snn 30 31
  • 79.46 (n)
 OneToOne
wufj47f06 30
Species where no ortholog for SNN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for SNN Gene

ENSEMBL:
Gene Tree for SNN (if available)
TreeFam:
Gene Tree for SNN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SNN: view image

Paralogs for SNN Gene

No data available for Paralogs for SNN Gene

Variants for SNN Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SNN Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs8191328 - p.Val17Ile
rs8191329 - p.Gly88Ser

Additional dbSNP identifiers (rs#s) for SNN Gene

Structural Variations from Database of Genomic Variants (DGV) for SNN Gene

Variant ID Type Subtype PubMed ID
esv22331 CNV loss 19812545
nsv1144756 CNV deletion 24896259
nsv457409 CNV gain 19166990
nsv524676 CNV loss 19592680
nsv571456 CNV gain 21841781
nsv952922 CNV deletion 24416366

Variation tolerance for SNN Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNN Gene

Disorders for SNN Gene

MalaCards: The human disease database

(7) MalaCards diseases for SNN Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search SNN in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SNN

Genetic Association Database
(GAD)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with SNN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNN Gene

Publications for SNN Gene

  1. Chromosomal localization and characterization of the stannin (Snn) gene. (PMID: 9657854) Dejneka NS … Billingsley ML (Mammalian genome : official journal of the International Mammalian Genome Society 1998) 2 3 4 23
  2. Structure, dynamics, and membrane topology of stannin: a mediator of neuronal cell apoptosis induced by trimethyltin chloride. (PMID: 16246365) Buck-Koehntop BA … Veglia G (Journal of molecular biology 2005) 3 4 23
  3. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. (PMID: 10233894) Horrevoets AJ … Pannekoek H (Blood 1999) 3 4 23
  4. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C … Stricker BH (Nature genetics 2009) 3 41
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

ExternalLinks

View latest publications for SNN gene in Mastermind

Products for SNN Gene

Sources for SNN Gene