This gene is located within the Prader-Willi critical region and produces a long, spliced paternally-imprinted RNA that initiates within a common upstream promoter region shared by the SNRPN (small nuclear ribonucleoprotein polypeptide N) and SNURF genes. This transcript serves as a host RNA for the small nucleolar RNA, C/D box 115 and 116 clusters. This RNA extends in antisens... See more...

Aliases for SNHG14 Gene

Subcategory (RNA class) for SNHG14 Gene

lncRNA

Number of RNA Genes sources:

3 / 14

Aliases for SNHG14 Gene

  • Small Nucleolar RNA Host Gene 14 2 3 5
  • Small Nucleolar RNA Host Gene 14 (Non-Protein Coding) 2 3
  • UBE3A Antisense RNA 1 (Non-Protein Coding) 2 3
  • SNHG14 2 168
  • Large Noncoding Antisense Transcript 3
  • UBE3A Antisense Transcript 3
  • Non-Protein Coding RNA 214 2
  • UBE3A Antisense 2
  • IC-SNURF-SNRPN 3
  • NONHSAG016302 92
  • HSALNG0104567 167
  • HSALNG0104546 167
  • HSALNG0104543 167
  • HSALNG0104558 167
  • NONHSAG016299 92
  • HSALNG0104552 167
  • Lnc-SNRPN-161 168
  • HSALNG0104563 167
  • HSALNG0104554 167
  • HSALNG0104565 167
  • NONHSAG016307 92
  • NONHSAG016309 92
  • Lnc-SNRPN-10 168
  • U-UBE3A-ATS 3
  • Lnc-SNRPN-8 168
  • NCRNA00214 3
  • UBE3A-ATS 3
  • UBE3A-AS1 3
  • UBE3A-AS 3
  • UBE3AATS 3
  • 115HG 3
  • LNCAT 3
  • PWAR6 2

External Ids for SNHG14 Gene

Previous HGNC Symbols for SNHG14 Gene

  • UBE3A-AS1

Previous GeneCards Identifiers for SNHG14 Gene

  • GC00U933595
  • GC15P025225
  • GC15P024985
  • GC15P025007
  • GC15P025028
  • GC15P025035
  • GC15P024824
  • GC15P025018

Summaries for SNHG14 Gene

Entrez Gene Summary for SNHG14 Gene

  • This gene is located within the Prader-Willi critical region and produces a long, spliced paternally-imprinted RNA that initiates within a common upstream promoter region shared by the SNRPN (small nuclear ribonucleoprotein polypeptide N) and SNURF genes. This transcript serves as a host RNA for the small nucleolar RNA, C/D box 115 and 116 clusters. This RNA extends in antisense into the region of the ubiquitin protein ligase E3A gene (UBE3A), and is thought to regulate imprinted expression of UBE3A in the brain. This transcript undergoes extensive alternative splicing, and may initiate and terminate at multiple locations within this genomic region. The full-length structure of all splice forms is not determined. [provided by RefSeq, Mar 2017]

GeneCards Summary for SNHG14 Gene

SNHG14 (Small Nucleolar RNA Host Gene 14) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with SNHG14 include Angelman Syndrome and Prader-Willi Syndrome.

Rfam classification for SNHG14 Gene

  • Small nucleolar RNA SNORD109A
  • Small nucleolar RNA SNORD115
  • Small nucleolar RNA SNORD116
  • Small nucleolar RNA SNORD107

Additional gene information for SNHG14 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNHG14 Gene

Genomics for SNHG14 Gene

GeneHancer (GH) Regulatory Elements for SNHG14 Gene

Promoters and enhancers for SNHG14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J024823 Promoter/Enhancer 0.9 Ensembl ENCODE 505.9 +0.3 293 1 NRF1 USF1 TEAD4 PKNOX1 SRF EP300 SP1 EGR1 POU5F1 POLR2A SNHG14 SNRPN ENSG00000280118 ENSG00000286110
GH15J024846 Promoter/Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 7.3 +24.1 24075 2.6 CTCF SMC3 GABPA TFDP1 RAD21 POLR2A GABPB1 TAF1 CHD7 YY1 ENSG00000280118 SNHG14 SNRPN ENSG00000286110
GH15J024856 Promoter/Enhancer 1 Ensembl ENCODE 7.2 +34.6 34624 4.3 NRF1 TEAD4 CTCF POLR2A FOXA2 SAP130 NANOG GABPB1 FOS JUND SNRPN SNHG14 ENSG00000280118 piR-49623 ENSG00000286110
GH15J025134 Enhancer 0.3 ENCODE 11.5 +311.2 311161 0.2 CTCF POLR2A PWAR1 SNORD116-29 SNORD116-30 SNHG14 ENSG00000212428 SNORD115-1 SNORD115-2 SNORD116-27 SNORD116-25 SNORD116-26
GH15J024784 Enhancer 0.4 Ensembl ENCODE 4.5 -38.8 -38755 0.7 MAFK SNHG14 piR-33185 piR-38352-186 ENSG00000286110 PWRN1 PWRN3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNHG14 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SNHG14 Gene

Genomic Locations for SNHG14 Gene
chr15:24,823,608-25,420,336
(GRCh38/hg38)
Size:
596,729 bases
Orientation:
Plus strand
chr15:25,223,730-25,664,609
(GRCh37/hg19)
Size:
440,880 bases
Orientation:
Plus strand

Genomic View for SNHG14 Gene

Genes around SNHG14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNHG14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNHG14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNHG14 Gene

Proteins for SNHG14 Gene

Post-translational modifications for SNHG14 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNHG14 Gene

Domains & Families for SNHG14 Gene

genes like me logo Genes that share domains with SNHG14: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SNHG14 Gene

Function for SNHG14 Gene

Phenotypes From GWAS Catalog for SNHG14 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SNHG14 Gene

Localization for SNHG14 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNHG14 gene
Compartment Confidence
plasma membrane 1
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SNHG14 Gene

Pathways & Interactions for SNHG14 Gene

PathCards logo

SuperPathways for SNHG14 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for SNHG14 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for SNHG14 Gene

Drugs & Compounds for SNHG14 Gene

No Compound Related Data Available

Transcripts for SNHG14 Gene

mRNA/cDNA for SNHG14 Gene

234 RNACentral transcripts :
2 REFSEQ mRNAs :
35 NCBI additional mRNA sequence :
142 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
82 NONCODE transcripts :
48 LncBook transcripts :
85 LNCipedia transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNHG14 Gene

No ASD Table

Relevant External Links for SNHG14 Gene

GeneLoc Exon Structure for
SNHG14

Expression for SNHG14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNHG14 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SNHG14

genes like me logo Genes that share expression patterns with SNHG14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNHG14 Gene

Orthologs for SNHG14 Gene

Evolution for SNHG14 Gene

ENSEMBL:
Gene Tree for SNHG14 (if available)
TreeFam:
Gene Tree for SNHG14 (if available)

No data available for Orthologs for SNHG14 Gene

Paralogs for SNHG14 Gene

No data available for Paralogs for SNHG14 Gene

Variants for SNHG14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SNHG14 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
570862 Uncertain Significance: Angelman syndrome 25,371,527(+) T/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
570995 Uncertain Significance: Angelman syndrome 25,371,441(+) A/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
571708 Uncertain Significance: Angelman syndrome 25,371,021(+) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT
573621 Uncertain Significance: Angelman syndrome 25,339,152(+) T/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
581141 Uncertain Significance: Angelman syndrome 25,375,484(+) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for SNHG14 Gene

Additional Variant Information for SNHG14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNHG14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SNHG14 Gene

Disorders for SNHG14 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SNHG14 Gene - From: LncRNADisease, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SNHG14

genes like me logo Genes that share disorders with SNHG14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNHG14 Gene

Publications for SNHG14 Gene

  1. Long non-coding RNA SNHG14 promotes microglia activation by regulating miR-145-5p/PLA2G4A in cerebral infarction. (PMID: 28215748) Qi X … Huo W (Neuroscience 2017) 2 3 54
  2. A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure. (PMID: 23771028) Powell WT … Lasalle JM (Human molecular genetics 2013) 2 3 54
  3. Regulation of the large (approximately 1000 kb) imprinted murine Ube3a antisense transcript by alternative exons upstream of Snurf/Snrpn. (PMID: 15226413) Landers M … Lalande M (Nucleic acids research 2004) 2 3 54
  4. SNHG14 enhances gemcitabine resistance by sponging miR-101 to stimulate cell autophagy in pancreatic cancer. (PMID: 30737032) Zhang X … Xin B (Biochemical and biophysical research communications 2019) 3 54
  5. Long non-coding RNA SNHG14 exerts oncogenic functions in non-small cell lung cancer through acting as an miR-340 sponge. (PMID: 30254102) Zhang Z … Lu W (Bioscience reports 2019) 3 54

Products for SNHG14 Gene

Sources for SNHG14 Gene