This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. [provided by Ref... See more...

Aliases for SNHG1 Gene

Data sources for SNHG1 Gene:

Subcategory (RNA class) for SNHG1 Gene

lncRNA

Aliases for SNHG1 Gene

External Ids for SNHG1 Gene

Previous GeneCards Identifiers for SNHG1 Gene

  • GC11U900889
  • GC11M062409
  • GC11M062419
  • GC11M062428
  • GC11M062619
  • GC11M062852
  • GC11M062862
  • GC11M062968
  • GC11M062992
  • GC11M063021
  • GC11M063085
  • GC11M062863
  • GC11M062869
  • GC11M062877
  • GC11M062887
  • GC11M062895
  • GC11M062903
  • GC11M062911
  • GC11M062934
  • GC11M063447

Summaries for SNHG1 Gene

Entrez Gene Summary for SNHG1 Gene

  • This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. [provided by RefSeq, Dec 2017]

GeneCards Summary for SNHG1 Gene

SNHG1 (Small Nucleolar RNA Host Gene 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with SNHG1 include Lung Squamous Cell Carcinoma and Neuroblastoma.

Rfam classification for SNHG1 Gene

  • Small nucleolar RNA SNORD22
  • Small nucleolar RNA SNORD29
  • Small nucleolar RNA SNORD25
  • Small nucleolar RNA SNORD27
  • Small nucleolar RNA SNORD28
  • Small nucleolar RNA SNORD31
  • Small nucleolar RNA SNORD30
  • Small nucleolar RNA SNORD26

Additional gene information for SNHG1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNHG1 Gene

Genomics for SNHG1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SNHG1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNHG1 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the SNHG1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • SREBP-1b
  • SREBP-1c

Genomic Locations for SNHG1 Gene

Latest Assembly
chr11:62,851,873-62,856,011
(GRCh38/hg38)
Size:
4,139 bases
Orientation:
Minus strand

Previous Assembly
chr11:62,619,450-62,623,357
(GRCh37/hg19 by Entrez Gene)
Size:
3,908 bases
Orientation:
Minus strand

chr11:62,619,460-62,623,386
(GRCh37/hg19 by Ensembl)
Size:
3,927 bases
Orientation:
Minus strand

Genomic View for SNHG1 Gene

Genes around SNHG1 on UCSC Golden Path with GeneCards custom track
SNHG1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
SNHG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNHG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNHG1 Gene

Proteins for SNHG1 Gene

Post-translational modifications for SNHG1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNHG1 Gene

Domains & Families for SNHG1 Gene

Gene Families for SNHG1 Gene

genes like me logo Genes that share domains with SNHG1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SNHG1 Gene

Function for SNHG1 Gene

Phenotypes From GWAS Catalog for SNHG1 Gene

CRISPR products for research

miRNA for SNHG1 Gene

miRTarBase miRNAs that target SNHG1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNHG1 Gene

Localization for SNHG1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNHG1 gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SNHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with SNHG1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SNHG1 Gene

Pathways & Interactions for SNHG1 Gene

PathCards logo

SuperPathways for SNHG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with SNHG1: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for SNHG1 Gene

Drugs & Compounds for SNHG1 Gene

No Compound Related Data Available

Transcripts for SNHG1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for SNHG1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00008C22F5_9606 lncRNA 1487 4

Ensembl: ENST00000537925 (view in UCSC) ,

LncBook: HSALNT0176342,

LNCipedia: SNHG1:10,

NONCODE: NONHSAT021828.2,

URS00008C409D_9606 lncRNA 1038 4

Ensembl: ENST00000537869 (view in UCSC) ,

LncBook: HSALNT0176357,

LNCipedia: SNHG1:27,

NONCODE: NONHSAT021831.2,

URS00008C3AA7_9606 lncRNA 955 4

Ensembl: ENST00000539975 (view in UCSC) ,

LncBook: HSALNT0176360,

LNCipedia: SNHG1:29,

NONCODE: NONHSAT021832.2,

URS00008C0CC6_9606 lncRNA 754 4

Ensembl: ENST00000545440 (view in UCSC) ,

LncBook: HSALNT0176364, HSALNT0288955,

LNCipedia: SNHG1:18,

NONCODE: NONHSAT021834.2,

URS00008C2147_9606 lncRNA 638 4

Ensembl: ENST00000537068 (view in UCSC) ,

LncBook: HSALNT0176341,

LNCipedia: SNHG1:5,

NONCODE: NONHSAT021824.2,

SNHG1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for SNHG1 Gene

16 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SNHG1 Gene

No ASD Table

Relevant External Links for SNHG1 Gene

GeneLoc Exon Structure for
SNHG1

Expression for SNHG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNHG1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SNHG1

SOURCE GeneReport for Unigene cluster for SNHG1 Gene:

Hs.655643
genes like me logo Genes that share expression patterns with SNHG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNHG1 Gene

Orthologs for SNHG1 Gene

Evolution for SNHG1 Gene

ENSEMBL:
Gene Tree for SNHG1 (if available)
TreeFam:
Gene Tree for SNHG1 (if available)

No data available for Orthologs for SNHG1 Gene

Paralogs for SNHG1 Gene

No data available for Paralogs for SNHG1 Gene

Variants for SNHG1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SNHG1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SNHG1 Gene

Variant ID Type Subtype PubMed ID
nsv1159903 CNV duplication 26073780
nsv508636 CNV deletion 20534489
nsv509416 CNV insertion 20534489

Additional Variant Information for SNHG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNHG1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SNHG1 Gene

Disorders for SNHG1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for SNHG1 Gene - From: LNC, COP, and GCD

Disorder Aliases PubMed IDs
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
neuroblastoma
  • nb
multiple pterygium syndrome, escobar variant
  • evmps
esophageal cancer
  • esophageal cancer, somatic
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search SNHG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SNHG1

genes like me logo Genes that share disorders with SNHG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNHG1 Gene

Publications for SNHG1 Gene

  1. LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells. (PMID: 29217406) Chen Y … Xie NC (Neurotoxicology 2018) 3 74
  2. Long non-coding RNA SNHG1 regulates NOB1 expression by sponging miR-326 and promotes tumorigenesis in osteosarcoma. (PMID: 29115574) Wang J … Wang Q (International journal of oncology 2018) 3 74
  3. Long noncoding RNA SNHG1 promotes non-small cell lung cancer progression by up-regulating MTDH via sponging miR-145-5p. (PMID: 29466052) Lu Q … Ren T (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018) 3 74
  4. SNHG1 lncRNA negatively regulates miR-199a-3p to enhance CDK7 expression and promote cell proliferation in prostate cancer. (PMID: 28400279) Li J … Wang J (Biochemical and biophysical research communications 2017) 3 74
  5. LncRNA-SNHG1 contributes to gastric cancer cell proliferation by regulating DNMT1. (PMID: 28754593) Hu Y … Tang Z (Biochemical and biophysical research communications 2017) 3 74

Products for SNHG1 Gene

Sources for SNHG1 Gene