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This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. [provided by Ref... See more...
Aliases for SNHG1 Gene
Data sources for SNHG1 Gene:
Subcategory (RNA class) for SNHG1 Gene
lncRNA
Aliases for SNHG1 Gene
- Small Nucleolar RNA Host Gene 1 (HGNC, NCBI Entrez Gene, Ensembl)
- Small Nucleolar RNA Host Gene 1 (Non-Protein Coding) (HGNC, NCBI Entrez Gene)
- Long Intergenic Non-Protein Coding RNA 57 (HGNC, NCBI Entrez Gene)
- NCRNA00057 (HGNC, NCBI Entrez Gene)
- LINC00057 (HGNC, NCBI Entrez Gene)
- LncRNA16 (HGNC, NCBI Entrez Gene)
- SNHG1 (Ensembl, LNCipedia)
- UHG (HGNC, NCBI Entrez Gene)
- Non-Protein Coding RNA 57 (HGNC)
- U22 SnoRNA Host Gene (HGNC)
- U22 SnoRNA Host (NCBI Entrez Gene)
- NONHSAG008552.2 (NONCODE)
- HSALNG0084672 (LncBook)
- RF00087 (Rfam)
- U22HG (NCBI Entrez Gene)
External Ids for SNHG1 Gene
- HGNC: 32688
- NCBI Entrez Gene: 23642
- Ensembl: ENSG00000255717
- OMIM®: 603222
Previous GeneCards Identifiers for SNHG1 Gene
- GC11U900889
- GC11M062409
- GC11M062419
- GC11M062428
- GC11M062619
- GC11M062852
- GC11M062862
- GC11M062968
- GC11M062992
- GC11M063021
- GC11M063085
- GC11M062863
- GC11M062869
- GC11M062877
- GC11M062887
- GC11M062895
- GC11M062903
- GC11M062911
- GC11M062934
- GC11M063447
Summaries for SNHG1 Gene
-
This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. [provided by RefSeq, Dec 2017]
GeneCards Summary for SNHG1 Gene
SNHG1 (Small Nucleolar RNA Host Gene 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with SNHG1 include Lung Squamous Cell Carcinoma and Neuroblastoma.
Rfam classification for SNHG1 Gene
Additional gene information for SNHG1 Gene
- HGNC (32688)
- NCBI Entrez Gene (23642)
- Ensembl (ENSG00000255717)
- OMIM® (603222)
- Open Targets Platform(ENSG00000255717)
- Search for SNHG1 at DataMed
- Search for SNHG1 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNHG1 Gene
Genomics for SNHG1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SNHG1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SNHG1 on the GeneHancer Hub at the UCSC Golden Path
- Top Transcription factor binding sites by QIAGEN in the SNHG1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- SREBP-1b
- SREBP-1c
Genomic Locations for SNHG1 Gene
Latest Assembly
- chr11:62,851,873-62,856,011
- (GRCh38/hg38)
- Size:
- 4,139 bases
- Orientation:
- Minus strand
Previous Assembly
- chr11:62,619,450-62,623,357
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 3,908 bases
- Orientation:
- Minus strand
- chr11:62,619,460-62,623,386
- (GRCh37/hg19 by Ensembl)
- Size:
- 3,927 bases
- Orientation:
- Minus strand
Genomic View for SNHG1 Gene
Genes around SNHG1 on UCSC Golden Path with GeneCards custom track
SNHG1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 11q12.3 by HGNC
- 11q12.3 by Entrez Gene
- 11q12.3 by Ensembl
SNHG1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SNHG1 Gene
Proteins for SNHG1 Gene
Post-translational modifications for SNHG1 Gene
No Post-translational modifications
No data available for DME Specific Peptides for SNHG1 Gene
Domains & Families for SNHG1 Gene
Gene Families for SNHG1 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SNHG1 Gene
Function for SNHG1 Gene
Phenotypes From GWAS Catalog for SNHG1 Gene
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SNHG1 - Starting at $85 >
- * SNHG1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
miRNA for SNHG1 Gene
- miRTarBase miRNAs that target SNHG1
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for SNHG1 - Starting at $45 >
- * SNHG1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNHG1 Gene
Localization for SNHG1 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005730 | nucleolus | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SNHG1 Gene
Pathways & Interactions for SNHG1 Gene
No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for SNHG1 Gene
Transcripts for SNHG1 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for SNHG1 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00008C22F5_9606 | lncRNA | 1487 | 4 |
Ensembl: ENST00000537925 (view in UCSC) , LncBook: HSALNT0176342, LNCipedia: SNHG1:10, NONCODE: NONHSAT021828.2, |
| URS00008C409D_9606 | lncRNA | 1038 | 4 |
Ensembl: ENST00000537869 (view in UCSC) , LncBook: HSALNT0176357, LNCipedia: SNHG1:27, NONCODE: NONHSAT021831.2, |
| URS00008C3AA7_9606 | lncRNA | 955 | 4 |
Ensembl: ENST00000539975 (view in UCSC) , LncBook: HSALNT0176360, LNCipedia: SNHG1:29, NONCODE: NONHSAT021832.2, |
| URS00008C0CC6_9606 | lncRNA | 754 | 4 |
Ensembl: ENST00000545440 (view in UCSC) , LncBook: HSALNT0176364, HSALNT0288955, LNCipedia: SNHG1:18, NONCODE: NONHSAT021834.2, |
| URS00008C2147_9606 | lncRNA | 638 | 4 |
Ensembl: ENST00000537068 (view in UCSC) , LncBook: HSALNT0176341, LNCipedia: SNHG1:5, NONCODE: NONHSAT021824.2, |
SNHG1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for SNHG1 Gene
- 16 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000535076 2812 nts (view in UCSC)
- ENST00000535689 2173 nts (view in UCSC)
- ENST00000537024 1727 nts (view in UCSC)
- ENST00000537965 2772 nts (view in UCSC)
- ENST00000538654 2769 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for SNHG1 - Starting at $85 >
- * SNHG1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for SNHG1 - Starting at $45 >
- * SNHG1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for SNHG1 Gene
- GeneLoc Exon Structure for
- SNHG1
Expression for SNHG1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SNHG1
SOURCE GeneReport for Unigene cluster for SNHG1 Gene:
Hs.655643Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNHG1 Gene
Orthologs for SNHG1 Gene
No data available for Orthologs for SNHG1 Gene
Paralogs for SNHG1 Gene
No data available for Paralogs for SNHG1 Gene
Variants for SNHG1 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for SNHG1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SNHG1
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for SNHG1 Gene
Disorders for SNHG1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lung squamous cell carcinoma |
|
|
| neuroblastoma |
|
|
| multiple pterygium syndrome, escobar variant |
|
|
| esophageal cancer |
|
|
| parkinson disease, late-onset |
|
Search SNHG1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SNHG1
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for SNHG1 Gene
Publications for SNHG1 Gene
- LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells. (PMID: 29217406) Chen Y … Xie NC (Neurotoxicology 2018) 3 74
- Long non-coding RNA SNHG1 regulates NOB1 expression by sponging miR-326 and promotes tumorigenesis in osteosarcoma. (PMID: 29115574) Wang J … Wang Q (International journal of oncology 2018) 3 74
- Long noncoding RNA SNHG1 promotes non-small cell lung cancer progression by up-regulating MTDH via sponging miR-145-5p. (PMID: 29466052) Lu Q … Ren T (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018) 3 74
- SNHG1 lncRNA negatively regulates miR-199a-3p to enhance CDK7 expression and promote cell proliferation in prostate cancer. (PMID: 28400279) Li J … Wang J (Biochemical and biophysical research communications 2017) 3 74
- LncRNA-SNHG1 contributes to gastric cancer cell proliferation by regulating DNMT1. (PMID: 28754593) Hu Y … Tang Z (Biochemical and biophysical research communications 2017) 3 74
ExternalLinks
Products for SNHG1 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for SNHG1
- Origene Custom Protein Services for SNHG1
- Browse OriGene Inhibitory RNA Products For SNHG1
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for SNHG1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SNHG1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- antibodies-online: Search results for available SNHG1 related products ranked by validation data
- antibodies-online: Search results for available SNHG1 related products ranked by validation data
- antibodies-online: Search results for available SNHG1 related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for SNHG1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for SNHG1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SNHG1
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for SNHG1
Sources for SNHG1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB