SNHG1 Gene (RNA Gene)

Small Nucleolar RNA Host Gene 1

GC11M063021
GIFtS:
20
This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. [provided by Ref... See more...

Aliases for SNHG1 Gene

Subcategory (RNA class) for SNHG1 Gene

lncRNA

Quality Score for this RNA gene is

15

Aliases for SNHG1 Gene

  • Small Nucleolar RNA Host Gene 1 2 3 5
  • Small Nucleolar RNA Host Gene 1 (Non-Protein Coding) 2 3
  • Long Intergenic Non-Protein Coding RNA 57 2 3
  • SNHG1 2 170
  • Non-Protein Coding RNA 57 2
  • U22 SnoRNA Host Gene 2
  • U22 SnoRNA Host 3
  • HSALNG0084672 169
  • NONHSAG008552 94
  • NCRNA00057 3
  • LINC00057 3
  • LncRNA16 3
  • U22HG 3
  • UHG 3

External Ids for SNHG1 Gene

Previous GeneCards Identifiers for SNHG1 Gene

  • GC11U900889
  • GC11M062409
  • GC11M062419
  • GC11M062428
  • GC11M062619
  • GC11M062852
  • GC11M062862
  • GC11M062968
  • GC11M062992
  • GC11M062863
  • GC11M062869
  • GC11M062877
  • GC11M062887
  • GC11M062895
  • GC11M062903
  • GC11M062911
  • GC11M062934

Summaries for SNHG1 Gene

Entrez Gene Summary for SNHG1 Gene

  • This locus represents a small nucleolar RNA host gene that produces multiple alternatively spliced long non-coding RNAs. This gene is upregulated in cancers and is thought to act as promoter of cell proliferation. This transcript negatively regulates tumor suppressor genes such as tumor protein p53. Expression of this locus may be a marker of tumor progression. [provided by RefSeq, Dec 2017]

GeneCards Summary for SNHG1 Gene

SNHG1 (Small Nucleolar RNA Host Gene 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with SNHG1 include Multiple Pterygium Syndrome, Escobar Variant and Astrocytoma.

Rfam classification for SNHG1 Gene

  • Small nucleolar RNA SNORD22
  • Small nucleolar RNA SNORD29
  • Small nucleolar RNA SNORD25
  • Small nucleolar RNA SNORD27
  • Small nucleolar RNA SNORD28
  • Small nucleolar RNA SNORD31
  • Small nucleolar RNA SNORD30
  • Small nucleolar RNA SNORD26

Additional gene information for SNHG1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for SNHG1 Gene

Genomics for SNHG1 Gene

GeneHancer (GH) Regulatory Elements for SNHG1 Gene

Promoters and enhancers for SNHG1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNHG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNHG1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • SREBP-1b
  • SREBP-1c

Genomic Locations for SNHG1 Gene

Genomic Locations for SNHG1 Gene
chr11:62,851,874-62,856,011
(GRCh38/hg38)
Size:
4,138 bases
Orientation:
Minus strand
chr11:62,619,460-62,623,386
(GRCh37/hg19)
Size:
3,927 bases
Orientation:
Minus strand

Genomic View for SNHG1 Gene

Genes around SNHG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNHG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNHG1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SNHG1 Gene

Proteins for SNHG1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for SNHG1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SNHG1 Gene

Domains & Families for SNHG1 Gene

Gene Families for SNHG1 Gene

HGNC:
genes like me logo Genes that share domains with SNHG1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SNHG1 Gene

Function for SNHG1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for SNHG1 Gene

Animal Model Products

CRISPR Products

miRNA for SNHG1 Gene

miRTarBase miRNAs that target SNHG1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNHG1 Gene

Localization for SNHG1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNHG1 gene
Compartment Confidence
nucleus 1

Gene Ontology (GO) - Cellular Components for SNHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with SNHG1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for SNHG1 Gene

Pathways & Interactions for SNHG1 Gene

PathCards logo

SuperPathways for SNHG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SNHG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
genes like me logo Genes that share ontologies with SNHG1: view

No data available for Pathways by source and SIGNOR curated interactions for SNHG1 Gene

Drugs & Compounds for SNHG1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for SNHG1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SNHG1 Gene

(12) REFSEQ mRNAs :
(16) Additional mRNA sequences :
(54) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(29) NONCODE transcripts :
(78) RNACentral transcripts :
(56) LncBook transcripts :
(64) LNCipedia transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNHG1 Gene

No ASD Table

Relevant External Links for SNHG1 Gene

GeneLoc Exon Structure for
SNHG1
ECgene alternative splicing isoforms for
SNHG1

Expression for SNHG1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNHG1 Gene

mRNA expression in normal human tissues for SNHG1 Gene
mRNA expression by GTEx for SNHG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SNHG1 Gene:

SNHG1

SOURCE GeneReport for Unigene cluster for SNHG1 Gene:

Hs.655643

Evidence on tissue expression from TISSUES for SNHG1 Gene

  • Urine(2.5)
genes like me logo Genes that share expression patterns with SNHG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNHG1 Gene

Orthologs for SNHG1 Gene

Evolution for SNHG1 Gene

ENSEMBL:
Gene Tree for SNHG1 (if available)
TreeFam:
Gene Tree for SNHG1 (if available)

No data available for Orthologs for SNHG1 Gene

Paralogs for SNHG1 Gene

No data available for Paralogs for SNHG1 Gene

Variants for SNHG1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for SNHG1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000055291 -- 62,855,272(-) T/G intron_variant
rs1000661059 -- 62,855,896(-) C/T upstream_transcript_variant
rs1000988950 -- 62,855,843(-) T/A/C intron_variant, non_coding_transcript_variant
rs1001419761 -- 62,855,320(-) T/C intron_variant
rs1002424048 -- 62,855,938(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNHG1 Gene

Variant ID Type Subtype PubMed ID
nsv1159903 CNV duplication 26073780
nsv508636 CNV deletion 20534489
nsv509416 CNV insertion 20534489

Additional Variant Information for SNHG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNHG1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SNHG1 Gene

Disorders for SNHG1 Gene

MalaCards: The human disease database

(12) MalaCards diseases for SNHG1 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
multiple pterygium syndrome, escobar variant
  • evmps
astrocytoma
  • astrocytic tumor
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
neuroblastoma 1
  • neuroblastoma, susceptibility to, 1
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search SNHG1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SNHG1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SNHG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNHG1 Gene

Publications for SNHG1 Gene

  1. LncRNA16 is a potential biomarker for diagnosis of early-stage lung cancer that promotes cell proliferation by regulating the cell cycle. (PMID: 27999202) Zhu H … Wu N (Oncotarget 2017) 2 3 56
  2. The Use of Three Long Non-Coding RNAs as Potential Prognostic Indicators of Astrocytoma. (PMID: 26252651) Zhi F … Yang Y (PloS one 2015) 2 3 56
  3. Analysis of long non-coding RNA expression profiles in gastric cancer. (PMID: 23801869) Cao WJ … Zhang ZY (World journal of gastroenterology 2013) 2 3 56
  4. A mammalian gene with introns instead of exons generating stable RNA products. (PMID: 8559254) Tycowski KT … Steitz JA (Nature 1996) 2 3 56
  5. LncRNA SNHG1 promoted HGC-27 cell growth and migration via the miR-140/ADAM10 axis. (PMID: 30391432) Guo W … Li X (International journal of biological macromolecules 2019) 3 56

ExternalLinks

View latest publications for SNHG1 gene in Mastermind

Products for SNHG1 Gene

Sources for SNHG1 Gene