Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SND1 Gene

Aliases for SND1 Gene

  • Staphylococcal Nuclease And Tudor Domain Containing 1 2 3 5
  • Tudor Domain-Containing Protein 11 3 4
  • EBNA2 Coactivator P100 3 4
  • Tudor-SN 2 3
  • TDRD11 3 4
  • Staphylococcal Nuclease Domain-Containing Protein 1 3
  • Testis Tissue Sperm-Binding Protein Li 82P 3
  • P100 EBNA2 Co-Activator 2
  • 100 KDa Coactivator 4
  • P100 Co-Activator 4
  • P100 3

External Ids for SND1 Gene

Previous GeneCards Identifiers for SND1 Gene

  • GC07P126846
  • GC07P126886
  • GC07P127079
  • GC07P127292
  • GC07P121653

Summaries for SND1 Gene

Entrez Gene Summary for SND1 Gene

  • This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]

GeneCards Summary for SND1 Gene

SND1 (Staphylococcal Nuclease And Tudor Domain Containing 1) is a Protein Coding gene. Diseases associated with SND1 include Myasthenic Syndrome, Congenital, 7, Presynaptic and Pituitary-Dependent Cushing's Disease. Among its related pathways are Oncogenic MAPK signaling and Epstein-Barr virus infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and transcription cofactor activity.

UniProtKB/Swiss-Prot for SND1 Gene

  • Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).

Gene Wiki entry for SND1 Gene

Additional gene information for SND1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SND1 Gene

Genomics for SND1 Gene

GeneHancer (GH) Regulatory Elements for SND1 Gene

Promoters and enhancers for SND1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I127650 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 574.3 +0.5 469 3.7 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 SND1 ENSG00000240790 GC07P127653 GC07P127654 GCC1 ZNF800 ENSG00000243302 FSCN3 RPS10P15 RBM28
GH07I127890 Enhancer 1.1 ENCODE dbSUPER 31.9 +239.9 239910 2.3 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 E2F8 ATF7 SND1 LRRC4 GC07P127895 GC07M127883
GH07I128005 Enhancer 1 ENCODE dbSUPER 30.3 +353.7 353708 1.3 MEIS2 SOX13 TFAP4 TAL1 EBF1 RAD21 RARA YY1 TEAD3 TCF12 SND1 LRRC4 LOC105375492 SND1-IT1
GH07I127819 Enhancer 1.1 Ensembl ENCODE 24.4 +168.4 168444 2 HDGF PKNOX1 ATF1 FOXA2 FEZF1 GLI4 ZNF2 GLIS2 FOS ATF7 SND1 ENSG00000240790 LRRC4 LOC100196944 PIR48128
GH07I127865 Enhancer 0.8 ENCODE dbSUPER 31.2 +213.6 213564 0.2 MEIS2 PKNOX1 ZNF362 TEAD1 TEAD2 NR2F2 RARA TEAD3 OSR2 ZBTB48 SND1 LRRC4 ENSG00000240790 GC07M127871 PIR37043 GC07M127858
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SND1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SND1 gene promoter:

Genomic Locations for SND1 Gene

Genomic Locations for SND1 Gene
440,491 bases
Plus strand

Genomic View for SND1 Gene

Genes around SND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SND1 Gene

Proteins for SND1 Gene

  • Protein details for SND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Staphylococcal nuclease domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q13122
    • Q96AG0

    Protein attributes for SND1 Gene

    910 amino acids
    Molecular mass:
    101997 Da
    Quaternary structure:
    • Binds to acidic transactivation domain of EBNA2. Interacts with EAV NSP1. Interacts with GTF2E1 and GTF2E2. Forms a ternary complex with STAT6 and POLR2A. Interacts with STAT5 (By similarity).
    • Sequence=AAA80488.1; Type=Frameshift; Positions=5; Note=The frameshift leads to wrong initiation.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SND1 Gene

neXtProt entry for SND1 Gene

Post-translational modifications for SND1 Gene

  • Phosphorylated by PIM1 in vitro.
  • Ubiquitination at isoforms=177, posLast=193193, posLast=249249, isoforms=366, posLast=515515, posLast=641641, and posLast=886886

Other Protein References for SND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SND1 Gene

Domains & Families for SND1 Gene

Gene Families for SND1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SND1: view

No data available for UniProtKB/Swiss-Prot for SND1 Gene

Function for SND1 Gene

Molecular function for SND1 Gene

UniProtKB/Swiss-Prot Function:
Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).

Phenotypes From GWAS Catalog for SND1 Gene

Gene Ontology (GO) - Molecular Function for SND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003712 transcription cofactor activity TAS 7651391
GO:0003723 RNA binding HDA,IDA 22658674
GO:0004518 nuclease activity IBA --
GO:0005515 protein binding IPI 20643132
genes like me logo Genes that share ontologies with SND1: view
genes like me logo Genes that share phenotypes with SND1: view

Animal Model Products

Clone Products

  • Addgene plasmids for SND1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SND1 Gene

Localization for SND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SND1 Gene

Cytoplasm. Nucleus. Melanosome. Note=In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SND1 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
mitochondrion 3
plasma membrane 2
cytoskeleton 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,TAS --
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA,IDA 16210410
genes like me logo Genes that share ontologies with SND1: view

Pathways & Interactions for SND1 Gene

genes like me logo Genes that share pathways with SND1: view

Pathways by source for SND1 Gene

Gene Ontology (GO) - Biological Process for SND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation HDA 16210410
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006401 RNA catabolic process IBA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with SND1: view

No data available for SIGNOR curated interactions for SND1 Gene

Drugs & Compounds for SND1 Gene

No Compound Related Data Available

Transcripts for SND1 Gene

mRNA/cDNA for SND1 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SND1 Gene

Staphylococcal nuclease and tudor domain containing 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for SND1

Alternative Splicing Database (ASD) splice patterns (SP) for SND1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^
SP1: - -
SP4: - - - - - - - - - - - - - - -

ExUns: 23a · 23b ^ 24 ^ 25a · 25b
SP1: -
SP2: -

Relevant External Links for SND1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SND1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SND1 Gene

Protein differential expression in normal tissues from HIPED for SND1 Gene

This gene is overexpressed in Bone marrow stromal cell (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SND1 Gene

Protein tissue co-expression partners for SND1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SND1 Gene:


SOURCE GeneReport for Unigene cluster for SND1 Gene:


mRNA Expression by UniProt/SwissProt for SND1 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for SND1 Gene

  • Nervous system(4.9)
  • Liver(4.7)
  • Lung(4.5)
  • Intestine(4.3)
  • Skin(3.8)
  • Kidney(3.2)
  • Pancreas(3.1)
  • Blood(3)
  • Heart(2.7)
  • Eye(2.6)
  • Adrenal gland(2.4)
  • Muscle(2.4)
  • Gall bladder(2.1)
  • Stomach(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with SND1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SND1 Gene

Orthologs for SND1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SND1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SND1 33 34
  • 99.74 (n)
(Monodelphis domestica)
Mammalia SND1 34
  • 96 (a)
(Canis familiaris)
Mammalia SND1 33 34
  • 93.19 (n)
(Ornithorhynchus anatinus)
Mammalia SND1 34
  • 93 (a)
(Bos Taurus)
Mammalia SND1 33 34
  • 91.94 (n)
(Mus musculus)
Mammalia Snd1 33 16 34
  • 90.71 (n)
(Rattus norvegicus)
Mammalia Snd1 33
  • 90.19 (n)
(Anolis carolinensis)
Reptilia SND1 34
  • 96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia snd1 33
  • 77 (n)
MGC76153 33
African clawed frog
(Xenopus laevis)
Amphibia 2e999-prov 33
(Danio rerio)
Actinopterygii snd1 33 34
  • 75.19 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005672 33
  • 56.03 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tudor-SN 33 34
  • 54.76 (n)
(Caenorhabditis elegans)
Secernentea tsn-1 33 34
  • 54.19 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons Tudor2 33
  • 48.75 (n)
(Oryza sativa)
Liliopsida Os02g0523500 33
  • 49.74 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5484 34
  • 57 (a)
-- 34
  • 55 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02134 33
  • 47.8 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes snd1 33
  • 44.53 (n)
Species where no ortholog for SND1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SND1 Gene

Gene Tree for SND1 (if available)
Gene Tree for SND1 (if available)

Paralogs for SND1 Gene

No data available for Paralogs for SND1 Gene

Variants for SND1 Gene

Sequence variations from dbSNP and Humsavar for SND1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs796052170 likely-benign, Long QT syndrome 128,074,593(+) A/C coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000021083 -- 127,844,123(+) G/T intron_variant
rs1000024326 -- 127,991,743(+) G/T intron_variant
rs1000034589 -- 128,069,574(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000040885 -- 127,978,728(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SND1 Gene

Variant ID Type Subtype PubMed ID
nsv956008 CNV deletion 24416366
nsv949938 CNV duplication 24416366
nsv831123 CNV gain 17160897
nsv831122 CNV gain 17160897
nsv5944 CNV insertion 18451855
nsv5942 CNV insertion 18451855
nsv526535 CNV gain 19592680
nsv526032 CNV loss 19592680
nsv510115 OTHER sequence alteration 20534489
nsv478932 CNV novel sequence insertion 20440878
nsv478049 CNV novel sequence insertion 20440878
nsv477290 CNV novel sequence insertion 20440878
nsv365757 CNV deletion 16902084
nsv1144199 CNV deletion 24896259
nsv1137289 CNV deletion 24896259
nsv1122171 CNV deletion 24896259
nsv1075996 CNV deletion 25765185
nsv1075995 CNV deletion 25765185
nsv1031658 CNV gain 25217958
nsv1024743 CNV gain 25217958
esv997448 CNV deletion 20482838
esv6141 CNV loss 19470904
esv3614963 CNV loss 21293372
esv3614962 CNV gain 21293372
esv3614960 CNV loss 21293372
esv3614958 CNV loss 21293372
esv3572134 CNV loss 25503493
esv3542407 CNV deletion 23714750
esv3438774 CNV insertion 20981092
esv3342788 CNV insertion 20981092
esv3303847 CNV mobile element insertion 20981092
esv3303184 CNV mobile element insertion 20981092
esv2735127 CNV deletion 23290073
esv2735126 CNV deletion 23290073
esv2663660 CNV deletion 23128226
esv2656712 CNV deletion 23128226
esv2612143 CNV insertion 19546169
esv2558418 CNV deletion 19546169
esv2401641 CNV deletion 18987734
dgv3663n106 CNV deletion 24896259

Variation tolerance for SND1 Gene

Residual Variation Intolerance Score: 6.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SND1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SND1 Gene

Disorders for SND1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SND1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
myasthenic syndrome, congenital, 7, presynaptic
  • cms7
pituitary-dependent cushing's disease
  • overproduction of acth
- elite association - COSMIC cancer census association via MalaCards
Search SND1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SND1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SND1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SND1 Gene

Publications for SND1 Gene

  1. Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. (PMID: 12234934) Yang J … Silvennoinen O (The EMBO journal 2002) 3 4 22 58
  2. The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development. (PMID: 9003410) Callebaut I … Mornon JP (The Biochemical journal 1997) 2 3 22 58
  3. The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE. (PMID: 7651391) Tong X … Kieff E (Molecular and cellular biology 1995) 2 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58

Products for SND1 Gene

Sources for SND1 Gene

Loading form....