External Ids for SNCB Gene
Previous GeneCards Identifiers for SNCB Gene
This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for SNCB Gene
SNCB (Synuclein Beta) is a Protein Coding gene. Diseases associated with SNCB include Dementia, Lewy Body and Dementia. Among its related pathways are Neuroscience. Gene Ontology (GO) annotations related to this gene include calcium ion binding and alpha-tubulin binding. An important paralog of this gene is SNCA.
UniProtKB/Swiss-Prot Summary for SNCB Gene
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.