Aliases for SNCAIP Gene
External Ids for SNCAIP Gene
Previous GeneCards Identifiers for SNCAIP Gene
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
GeneCards Summary for SNCAIP Gene
SNCAIP (Synuclein Alpha Interacting Protein) is a Protein Coding gene. Diseases associated with SNCAIP include Parkinson Disease, Late-Onset and Dementia, Lewy Body. Among its related pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Parkinsons Disease Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and ubiquitin protein ligase binding.
UniProtKB/Swiss-Prot Summary for SNCAIP Gene
Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.