This gene encodes a subunit of the small nuclear RNA (snRNA)-activating protein complex that plays a role in the transcription of snRNA genes. This complex binds to the promoters of snRNA genes transcribed by either RNA polymerase II or III and recruits other regulatory factors to activate snRNA gene transcription. The encoded protein may play a role in stabilizing this complex... See more...

Aliases for SNAPC5 Gene

Aliases for SNAPC5 Gene

  • Small Nuclear RNA Activating Complex Polypeptide 5 2 3 5
  • SnRNA-Activating Protein Complex 19 KDa Subunit 3 4
  • SnRNA-Activating Protein Complex Subunit 5 3 4
  • SNAPc 19 KDa Subunit 3 4
  • SNAPc Subunit 5 3 4
  • SNAP19 3 4
  • Small Nuclear RNA Activating Complex, Polypeptide 5, 19kDa 2
  • Small Nuclear RNA Activating Complex, Polypeptide 5, 19kD 2
  • Small Nuclear RNA-Activating Complex Polypeptide 5 4

External Ids for SNAPC5 Gene

Previous GeneCards Identifiers for SNAPC5 Gene

  • GC15M062578
  • GC15M059884
  • GC15M064360
  • GC15M064502
  • GC15M064573
  • GC15M066782
  • GC15M043618

Summaries for SNAPC5 Gene

Entrez Gene Summary for SNAPC5 Gene

  • This gene encodes a subunit of the small nuclear RNA (snRNA)-activating protein complex that plays a role in the transcription of snRNA genes. This complex binds to the promoters of snRNA genes transcribed by either RNA polymerase II or III and recruits other regulatory factors to activate snRNA gene transcription. The encoded protein may play a role in stabilizing this complex. A pseudogene of this gene has been identified on chromosome 6. [provided by RefSeq, Jul 2016]

GeneCards Summary for SNAPC5 Gene

SNAPC5 (Small Nuclear RNA Activating Complex Polypeptide 5) is a Protein Coding gene. Diseases associated with SNAPC5 include Lung Carcinoma In Situ and Rasopathy. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and RNA Polymerase III Transcription Initiation. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity.

UniProtKB/Swiss-Prot Summary for SNAPC5 Gene

  • Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Gene Wiki entry for SNAPC5 Gene

Additional gene information for SNAPC5 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SNAPC5 Gene

Genomics for SNAPC5 Gene

GeneHancer (GH) Regulatory Elements for SNAPC5 Gene

Promoters and enhancers for SNAPC5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNAPC5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SNAPC5

Top Transcription factor binding sites by QIAGEN in the SNAPC5 gene promoter:
  • FOXF2
  • Meis-1
  • Meis-1a
  • Meis-1b
  • TBP
  • TFIID

Genomic Locations for SNAPC5 Gene

Genomic Locations for SNAPC5 Gene
chr15:66,490,135-66,497,808
(GRCh38/hg38)
Size:
7,674 bases
Orientation:
Minus strand
chr15:66,782,473-66,790,151
(GRCh37/hg19)
Size:
7,679 bases
Orientation:
Minus strand

Genomic View for SNAPC5 Gene

Genes around SNAPC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAPC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAPC5 Gene

Proteins for SNAPC5 Gene

  • Protein details for SNAPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75971-SNPC5_HUMAN
    Recommended name:
    snRNA-activating protein complex subunit 5
    Protein Accession:
    O75971
    Secondary Accessions:
    • A8K7N6
    • Q96CF3

    Protein attributes for SNAPC5 Gene

    Size:
    98 amino acids
    Molecular mass:
    11328 Da
    Quaternary structure:
    • Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC5 interacts with SNAPC4.

    Alternative splice isoforms for SNAPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SNAPC5 Gene

Post-translational modifications for SNAPC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SNAPC5 Gene

Domains & Families for SNAPC5 Gene

Gene Families for SNAPC5 Gene

Protein Domains for SNAPC5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SNAPC5 Gene

GenScript: Design optimal peptide antigens:
  • snRNA-activating protein complex 19 kDa subunit (SNPC5_HUMAN)
genes like me logo Genes that share domains with SNAPC5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SNAPC5 Gene

Function for SNAPC5 Gene

Molecular function for SNAPC5 Gene

UniProtKB/Swiss-Prot Function:
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

Phenotypes From GWAS Catalog for SNAPC5 Gene

Gene Ontology (GO) - Molecular Function for SNAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SNAPC5: view
genes like me logo Genes that share phenotypes with SNAPC5: view

miRNA for SNAPC5 Gene

miRTarBase miRNAs that target SNAPC5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SNAPC5 Gene

Localization for SNAPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAPC5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNAPC5 gene
Compartment Confidence
nucleus 5
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SNAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with SNAPC5: view

Pathways & Interactions for SNAPC5 Gene

genes like me logo Genes that share pathways with SNAPC5: view

Gene Ontology (GO) - Biological Process for SNAPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS,IEA 9732265
GO:0006384 transcription initiation from RNA polymerase III promoter IEA --
GO:0042795 snRNA transcription by RNA polymerase II TAS --
genes like me logo Genes that share ontologies with SNAPC5: view

No data available for SIGNOR curated interactions for SNAPC5 Gene

Drugs & Compounds for SNAPC5 Gene

No Compound Related Data Available

Transcripts for SNAPC5 Gene

mRNA/cDNA for SNAPC5 Gene

4 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SNAPC5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d
SP1: - -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for SNAPC5 Gene

GeneLoc Exon Structure for
SNAPC5

Expression for SNAPC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNAPC5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SNAPC5 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SNAPC5

SOURCE GeneReport for Unigene cluster for SNAPC5 Gene:

Hs.30174

Evidence on tissue expression from TISSUES for SNAPC5 Gene

  • Spleen(4.2)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with SNAPC5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNAPC5 Gene

Orthologs for SNAPC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SNAPC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAPC5 31 30
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SNAPC5 31 30
  • 91.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SNAPC5 31 30
  • 86.9 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snapc5 30
  • 81.35 (n)
mouse
(Mus musculus)
Mammalia Snapc5 17 31 30
  • 80.08 (n)
oppossum
(Monodelphis domestica)
Mammalia SNAPC5 31
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNAPC5 31 30
  • 67.9 (n)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1394 30
zebrafish
(Danio rerio)
Actinopterygii snapc5 31
  • 44 (a)
OneToOne
Species where no ortholog for SNAPC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SNAPC5 Gene

ENSEMBL:
Gene Tree for SNAPC5 (if available)
TreeFam:
Gene Tree for SNAPC5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SNAPC5: view image

Paralogs for SNAPC5 Gene

Pseudogenes.org Pseudogenes for SNAPC5 Gene

genes like me logo Genes that share paralogs with SNAPC5: view

No data available for Paralogs for SNAPC5 Gene

Variants for SNAPC5 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SNAPC5 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
40761 Uncertain Significance: Rasopathy 66,489,757(-) A/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
659036 Uncertain Significance: Rasopathy 66,490,612(-) CTAAG/C FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
659397 Uncertain Significance: Rasopathy 66,490,568(-) A/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
666422 Likely Benign: Noonan syndrome 66,490,505(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
rs1009731985 Uncertain Significance: not specified 66,489,761(-) A/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for SNAPC5 Gene

Structural Variations from Database of Genomic Variants (DGV) for SNAPC5 Gene

Variant ID Type Subtype PubMed ID
nsv977729 CNV duplication 23825009

Variation tolerance for SNAPC5 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNAPC5 Gene

Human Gene Mutation Database (HGMD)
SNAPC5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNAPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAPC5 Gene

Disorders for SNAPC5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SNAPC5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung carcinoma in situ
rasopathy
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SNAPC5

genes like me logo Genes that share disorders with SNAPC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNAPC5 Gene

Publications for SNAPC5 Gene

  1. SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III. (PMID: 9732265) Henry RW … Hernandez N (Genes & development 1998) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc. (PMID: 11056176) Ma B … Hernandez N (The Journal of biological chemistry 2001) 3 4 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 54

Products for SNAPC5 Gene

Sources for SNAPC5 Gene