SNAI3 is a member of the SNAIL gene family, named for the Drosophila snail gene, which plays roles in mesodermal formation during embryogenesis (Katoh and Katoh, 2003 [PubMed 12579345]).[supplied by OMIM, Apr 2009] See more...

Aliases for SNAI3 Gene

Aliases for SNAI3 Gene

  • Snail Family Transcriptional Repressor 3 2 3 5
  • Zinc Finger Protein 293 2 3 4
  • Snail Family Zinc Finger 3 2 3
  • Zinc Finger Protein SNAI3 3 4
  • Protein Snail Homolog 3 3 4
  • ZNF293 3 4
  • Zfp293 2 3
  • SMUC 2 3
  • Snail Homolog 3 (Drosophila) 2
  • Snail Homolog 3 3
  • SNAIL3 3
  • SNAI3 5

External Ids for SNAI3 Gene

Previous HGNC Symbols for SNAI3 Gene

  • ZNF293

Previous GeneCards Identifiers for SNAI3 Gene

  • GC16U900013
  • GC16M088447
  • GC16M088488
  • GC16M087271
  • GC16M088744
  • GC16M074438

Summaries for SNAI3 Gene

Entrez Gene Summary for SNAI3 Gene

  • SNAI3 is a member of the SNAIL gene family, named for the Drosophila snail gene, which plays roles in mesodermal formation during embryogenesis (Katoh and Katoh, 2003 [PubMed 12579345]).[supplied by OMIM, Apr 2009]

GeneCards Summary for SNAI3 Gene

SNAI3 (Snail Family Transcriptional Repressor 3) is a Protein Coding gene. Diseases associated with SNAI3 include Parkinson Disease 7, Autosomal Recessive Early-Onset. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and copper ion binding. An important paralog of this gene is SNAI2.

UniProtKB/Swiss-Prot Summary for SNAI3 Gene

  • Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3' (By similarity).

Additional gene information for SNAI3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SNAI3 Gene

Genomics for SNAI3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SNAI3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNAI3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SNAI3

Top Transcription factor binding sites by QIAGEN in the SNAI3 gene promoter:
  • AP-2gamma
  • CBF(2)
  • E47
  • Egr-3
  • LCR-F1
  • NF-Y
  • Pax-5
  • PPAR-gamma2
  • Tal-1
  • YY1

Genomic Locations for SNAI3 Gene

Genomic Locations for SNAI3 Gene
chr16:88,677,688-88,686,507
(GRCh38/hg38)
Size:
8,820 bases
Orientation:
Minus strand
chr16:88,744,090-88,752,901
(GRCh37/hg19)
Size:
8,812 bases
Orientation:
Minus strand

Genomic View for SNAI3 Gene

Genes around SNAI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAI3 Gene

Proteins for SNAI3 Gene

  • Protein details for SNAI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KNW1-SNAI3_HUMAN
    Recommended name:
    Zinc finger protein SNAI3
    Protein Accession:
    Q3KNW1
    Secondary Accessions:
    • Q86SU5

    Protein attributes for SNAI3 Gene

    Size:
    292 amino acids
    Molecular mass:
    32474 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SNAI3 Gene

Post-translational modifications for SNAI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SNAI3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SNAI3

No data available for DME Specific Peptides for SNAI3 Gene

Domains & Families for SNAI3 Gene

Gene Families for SNAI3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SNAI3 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for SNAI3 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 293 (SNAI3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q3KNW1

UniProtKB/Swiss-Prot:

SNAI3_HUMAN :
  • Binds E-box via C2H2-type zinc finger domain.
  • Belongs to the snail C2H2-type zinc-finger protein family.
Domain:
  • Binds E-box via C2H2-type zinc finger domain.
Family:
  • Belongs to the snail C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with SNAI3: view

Function for SNAI3 Gene

Molecular function for SNAI3 Gene

UniProtKB/Swiss-Prot Function:
Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'-CAGGTG-3' and 5'-CACCTG-3' (By similarity).

Phenotypes From GWAS Catalog for SNAI3 Gene

Gene Ontology (GO) - Molecular Function for SNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IEA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SNAI3: view
genes like me logo Genes that share phenotypes with SNAI3: view

Animal Models for SNAI3 Gene

MGI Knock Outs for SNAI3:
  • Snai3 Snai3<tm1.2Jhws>
  • Snai3 Snai3<tm1.1Grid>
  • Snai3 Snai3<tm2.1Grid>
  • Snai3 Snai3<tm2b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for SNAI3 Gene

miRTarBase miRNAs that target SNAI3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNAI3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNAI3 Gene

Localization for SNAI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAI3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNAI3 gene
Compartment Confidence
nucleus 4
extracellular 2
cytoskeleton 2
cytosol 2
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with SNAI3: view

Pathways & Interactions for SNAI3 Gene

PathCards logo

SuperPathways for SNAI3 Gene

No Data Available

SIGNOR curated interactions for SNAI3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SNAI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA 21873635
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with SNAI3: view

No data available for Pathways by source for SNAI3 Gene

Drugs & Compounds for SNAI3 Gene

No Compound Related Data Available

Transcripts for SNAI3 Gene

mRNA/cDNA for SNAI3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNAI3

Alternative Splicing Database (ASD) splice patterns (SP) for SNAI3 Gene

No ASD Table

Relevant External Links for SNAI3 Gene

GeneLoc Exon Structure for
SNAI3

Expression for SNAI3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SNAI3 Gene

mRNA differential expression in normal tissues according to GTEx for SNAI3 Gene

This gene is overexpressed in Whole Blood (x15.6) and Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for SNAI3 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SNAI3 Gene



Protein tissue co-expression partners for SNAI3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SNAI3

SOURCE GeneReport for Unigene cluster for SNAI3 Gene:

Hs.673548

Evidence on tissue expression from TISSUES for SNAI3 Gene

  • Lung(4.3)
genes like me logo Genes that share expression patterns with SNAI3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNAI3 Gene

Orthologs for SNAI3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNAI3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SNAI3 30 31
  • 99.2 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SNAI3 30 31
  • 83.85 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SNAI3 30 31
  • 80.54 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Snai3 30
  • 77.58 (n)
Mouse
(Mus musculus)
Mammalia Snai3 30 17 31
  • 77.47 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SNAI3 31
  • 67 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SNAI3 31
  • 64 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SNAI3 31
  • 51 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia snai3 30
  • 58.43 (n)
Zebrafish
(Danio rerio)
Actinopterygii snai3 30 31
  • 56.49 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6891 30
Fruit Fly
(Drosophila melanogaster)
Insecta sna 31
  • 29 (a)
ManyToMany
esg 31
  • 28 (a)
ManyToMany
wor 31
  • 24 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea K02D7.2 31
  • 46 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8617 31
  • 49 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.15314 30
Species where no ortholog for SNAI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SNAI3 Gene

ENSEMBL:
Gene Tree for SNAI3 (if available)
TreeFam:
Gene Tree for SNAI3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SNAI3: view image

Paralogs for SNAI3 Gene

(9) SIMAP similar genes for SNAI3 Gene using alignment to 1 proteins:

  • SNAI3_HUMAN
genes like me logo Genes that share paralogs with SNAI3: view

Variants for SNAI3 Gene

Additional dbSNP identifiers (rs#s) for SNAI3 Gene

Structural Variations from Database of Genomic Variants (DGV) for SNAI3 Gene

Variant ID Type Subtype PubMed ID
dgv3064n100 CNV gain 25217958
nsv1065973 CNV loss 25217958
nsv471113 CNV loss 18288195
nsv482951 CNV loss 15286789
nsv819188 CNV gain 19587683
nsv819380 CNV gain 19587683
nsv833325 CNV loss 17160897
nsv833327 CNV loss 17160897
nsv952070 CNV deletion 24416366

Variation tolerance for SNAI3 Gene

Residual Variation Intolerance Score: 96.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNAI3 Gene

Human Gene Mutation Database (HGMD)
SNAI3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNAI3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SNAI3 Gene

Disorders for SNAI3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SNAI3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
parkinson disease 7, autosomal recessive early-onset
  • park7
- elite association - COSMIC cancer census association via MalaCards
Search SNAI3 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with SNAI3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNAI3 Gene

Publications for SNAI3 Gene

  1. Identification and characterization of human SNAIL3 (SNAI3) gene in silico. (PMID: 12579345) Katoh M … Katoh M (International journal of molecular medicine 2003) 2 3 23
  2. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  3. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3

Products for SNAI3 Gene

  • Signalway Proteins for SNAI3

Sources for SNAI3 Gene