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Aliases for SNAI1 Gene

Aliases for SNAI1 Gene

  • Snail Family Transcriptional Repressor 1 2 3 5
  • Snail Family Zinc Finger 1 2 3
  • Zinc Finger Protein SNAI1 3 4
  • Protein Snail Homolog 1 3 4
  • Protein Sna 3 4
  • SNAH 3 4
  • Snail 1 (Drosophila Homolog), Zinc Finger Protein 2
  • Snail Homolog 1 (Drosophila) 2
  • Snail 1 Zinc Finger Protein 3
  • Snail 1 Homolog 3
  • Snail Homolog 1 3
  • DJ710H13.1 3
  • SLUGH2 3
  • SNAIL1 3
  • SNAIL 3
  • SNA 3

External Ids for SNAI1 Gene

Previous GeneCards Identifiers for SNAI1 Gene

  • GC20P048328
  • GC20P049237
  • GC20P049284
  • GC20P048032
  • GC20P048599
  • GC20P045348

Summaries for SNAI1 Gene

Entrez Gene Summary for SNAI1 Gene

  • The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for SNAI1 Gene

SNAI1 (Snail Family Transcriptional Repressor 1) is a Protein Coding gene. Diseases associated with SNAI1 include Gastroesophageal Junction Adenocarcinoma and Fasciolopsiasis. Among its related pathways are Wnt / Hedgehog / Notch and PAK Pathway. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific. An important paralog of this gene is SNAI2.

UniProtKB/Swiss-Prot for SNAI1 Gene

  • Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

Gene Wiki entry for SNAI1 Gene

Additional gene information for SNAI1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SNAI1 Gene

Genomics for SNAI1 Gene

GeneHancer (GH) Regulatory Elements for SNAI1 Gene

Promoters and enhancers for SNAI1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J049981 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 616.3 +3.7 3663 9.5 SP1 CC2D1A ELF3 ZFX CTCF ZKSCAN8 MNT ZNF148 NKRF POLR2A SNAI1 DDX27 ADNP DPM1 RNF114 SLC9A8 MOCS3 SPATA2 ENSG00000232043 PSMD10P1
GH20J050140 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 33.6 +164.8 164751 14.2 MTA3 SP1 ZFX ELF3 ZKSCAN8 MNT CBFA2T2 NKRF POLR2A ZNF121 TMEM189 TMEM189-UBE2V1 DPM1 SNAI1 SLC9A8 DDX27 LINC01273 ADNP B4GALT5 PTPN1
GH20J049709 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.2 -270.4 -270375 5.2 SP1 ELF3 ZFX MNT ZNF148 NKRF POLR2A MLLT1 CEBPG GTF2F1 B4GALT5 SLC9A8 SNAI1 ZNFX1 CEBPB TMEM189 RNF114 GC20M049705
GH20J050272 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 28.6 +296.7 296711 16.9 ZNF652 ELF3 CC2D1A CTCF ZKSCAN8 CBFA2T2 ZNF148 MLLT1 ZNF121 CEBPG CEBPB ADNP SLC9A8 DPM1 PTPN1 SNAI1 LINC01270 ENSG00000232043 LINC01273 MIR645
GH20J050438 Enhancer 1.6 FANTOM5 ENCODE dbSUPER 37.2 +457.8 457821 5 MTA3 ZNF652 CC2D1A ELF3 ZKSCAN8 MNT CBFA2T2 MLLT1 CEBPG RERE SNAI1 ADNP CEBPB PTPN1 DPM1 LINC01273 KRT18P4 ENSG00000232043 TMEM189 RN7SL636P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SNAI1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SNAI1 gene promoter:
  • AP-1
  • AREB6
  • Arnt
  • ATF-2
  • c-Jun
  • CREB
  • Nkx2-5
  • SEF-1 (1)

Genomic Locations for SNAI1 Gene

Genomic Locations for SNAI1 Gene
chr20:49,982,976-49,988,886
(GRCh38/hg38)
Size:
5,911 bases
Orientation:
Plus strand
chr20:48,599,513-48,605,423
(GRCh37/hg19)
Size:
5,911 bases
Orientation:
Plus strand

Genomic View for SNAI1 Gene

Genes around SNAI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SNAI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SNAI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SNAI1 Gene

Proteins for SNAI1 Gene

  • Protein details for SNAI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95863-SNAI1_HUMAN
    Recommended name:
    Zinc finger protein SNAI1
    Protein Accession:
    O95863
    Secondary Accessions:
    • B2R842
    • Q9P113
    • Q9UBP7
    • Q9UHH7

    Protein attributes for SNAI1 Gene

    Size:
    264 amino acids
    Molecular mass:
    29083 Da
    Quaternary structure:
    • Interacts with FBXL14 and GSK3B. Interacts with BTRC; interaction occurs when it is phosphorylated on the destruction motif. Interacts (via SNAG domain) with WTIP (via LIM domains) (By similarity). Interacts (via SNAG domain) with LIMD1 (via LIM domains), and AJUBA (via LIM domains). Interacts with LOXL2 and LOXL3. Interacts (via N-terminal region) with CSNK2A1. Interacts with EGR1 upon TPA induction. Interacts (via N-terminal region) with LATS2; the interaction is dependent on LATS2 kinase activity but independent of SNAI1 Thr-203 phosphorylation. Interacts (via zinc fingers) with KPNB1 and TNPO1; the interactions mediate nuclear import. Interacts (via zinc fingers) with KPNA1; the interaction disrupts the transport complex with KPNB1 and prevents nuclear import increasing SNAI1 degradation in the cytoplasm. Interacts (via zinc fingers) with KPNA2; the interaction, in combination with KPNB1, mediates nuclear import. Interacts with KPNA4; this interaction mediates nuclear import. May interact (via zinc fingers) with IPO7. Interacts (via zinc fingers) with PARP1; the interaction requires SNAI1 to be poly-ADP-ribosylated and non-phosphorylated (active) by GSK3B. Interacts (via SNAG domain) with KDM1A (PubMed:20389281, PubMed:20562920, PubMed:21300290, PubMed:23721412). Interaction with KDM1A is necessary for the down-regulation of dimethylated H3K4 mark and promoter activity of E-cadherin/CDH1, CDN7 and KRT8 (PubMed:20389281, PubMed:20562920). Interacts with TP53/p53 and (via zinc fingers) with NOTCH1 (via intracellular domain); the interactions induce SNAI1 degradation via MDM2-mediated ubiquitination and inhibit SNAI1-induced cell invasion. Interacts with MDM2; the interaction promotes SNAI1 ubiquitination. Interacts (via zinc fingers) with CSNK1E. Interacts with PAK1 (PubMed:15833848).

    Three dimensional structures from OCA and Proteopedia for SNAI1 Gene

neXtProt entry for SNAI1 Gene

Post-translational modifications for SNAI1 Gene

  • Phosphorylated by GSK3B. Once phosphorylated, it becomes a target for BTRC ubiquitination. Phosphorylation by CSNK1E, probably at Ser-104, provides the priming site for the subsequent phosphorylation by GSK3B, probably at Ser-100 and Ser-96. Phosphorylation by PAK1 may modulate its transcriptional activity by promoting increased accumulation in the nucleus. Phosphorylation at Ser-11 and Ser-92 positively regulates its functions in induction of EMT and cell survival, respectively. Phosphorylation by LATS2, upon mitotic stress, oncogenic stress or Hippo pathway activation, occurs in the nucleus and promotes nuclear retention and stabilization of total cellular protein level.
  • Ubiquitinated on Lys-98, Lys-137 and Lys-146 by FBXL14 and BTRC leading to degradation. BTRC-triggered ubiquitination requires previous GSK3B-mediated SNAI1 phosphorylation. Ubiquitination induced upon interaction with NOTCH1 or TP53/p53 is mediated by MDM2.
  • O-GlcNAcylation at Ser-112 is enhanced in hyperglycaemic conditions, it opposes phosphorylation by GSK3B, and stabilizes the protein.
  • ADP-ribosylation by PARP1 increases protein half-life and may be involved in TGFB-induced SNAI1 up-regulation.
  • Ubiquitination at isoforms=146, isoforms=137, and isoforms=98
  • Glycosylation at posLast=112112
  • Modification sites at PhosphoSitePlus

Other Protein References for SNAI1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for SNAI1

No data available for DME Specific Peptides for SNAI1 Gene

Domains & Families for SNAI1 Gene

Gene Families for SNAI1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for SNAI1 Gene

Suggested Antigen Peptide Sequences for SNAI1 Gene

GenScript: Design optimal peptide antigens:
  • Protein snail homolog 1 (SNAI1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95863

UniProtKB/Swiss-Prot:

SNAI1_HUMAN :
  • Belongs to the snail C2H2-type zinc-finger protein family.
Family:
  • Belongs to the snail C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with SNAI1: view

Function for SNAI1 Gene

Molecular function for SNAI1 Gene

UniProtKB/Swiss-Prot Function:
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription (PubMed:20389281, PubMed:20562920). The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (PubMed:20389281, PubMed:21300290, PubMed:23721412). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (By similarity). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (By similarity). Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
UniProtKB/Swiss-Prot Induction:
Induced by TPA maximally by 2.5-fold at 4 hours, in HepG2 cells (at protein level).
GENATLAS Biochemistry:
zinc finger protein Drosophila snail 1 homolog,expressed in several fetal tissues with the highest expression in the kidney,also transcribed in adult tissues,particularly in lung and placenta,heart,brain,liver,skeletal muscle

Phenotypes From GWAS Catalog for SNAI1 Gene

Gene Ontology (GO) - Molecular Function for SNAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA,IEA 11912130
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA,IDA 11912130
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with SNAI1: view
genes like me logo Genes that share phenotypes with SNAI1: view

Animal Models for SNAI1 Gene

MGI Knock Outs for SNAI1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNAI1

Clone Products

  • Addgene plasmids for SNAI1
  • Applied Biological Materials (abm): Clones for SNAI1 - Now 50% OFF >
  • * SNAI1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SNAI1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SNAI1 Gene

Localization for SNAI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SNAI1 Gene

Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs. {ECO:0000269 PubMed:15448698}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SNAI1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
plasma membrane 2
extracellular 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SNAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005721 pericentric heterochromatin IDA 24239292
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with SNAI1: view

Pathways & Interactions for SNAI1 Gene

genes like me logo Genes that share pathways with SNAI1: view

Pathways by source for SNAI1 Gene

SIGNOR curated interactions for SNAI1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SNAI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0001649 osteoblast differentiation IEP 20128911
GO:0001707 mesoderm formation ISS,IEA --
GO:0001837 epithelial to mesenchymal transition ISS,IEA --
GO:0003180 aortic valve morphogenesis TAS 20951801
genes like me logo Genes that share ontologies with SNAI1: view

Drugs & Compounds for SNAI1 Gene

(1) Drugs for SNAI1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SNAI1: view

Transcripts for SNAI1 Gene

mRNA/cDNA for SNAI1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(108) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for SNAI1 Gene

Snail homolog 1 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SNAI1

Clone Products

  • Addgene plasmids for SNAI1
  • Applied Biological Materials (abm): Clones for SNAI1 - Now 50% OFF >
  • * SNAI1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * SNAI1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for SNAI1 Gene

No ASD Table

Relevant External Links for SNAI1 Gene

GeneLoc Exon Structure for
SNAI1
ECgene alternative splicing isoforms for
SNAI1

Expression for SNAI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SNAI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SNAI1 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of SNAI1 Gene:

SNAI1

SOURCE GeneReport for Unigene cluster for SNAI1 Gene:

Hs.48029

mRNA Expression by UniProt/SwissProt for SNAI1 Gene:

O95863-SNAI1_HUMAN
Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines.

Evidence on tissue expression from TISSUES for SNAI1 Gene

  • Lung(2.8)
  • Intestine(2.6)
  • Kidney(2.6)
  • Lymph node(2.6)
  • Skin(2.4)
  • Muscle(2.3)
  • Pancreas(2.3)
  • Nervous system(2.3)
  • Liver(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with SNAI1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SNAI1 Gene

Orthologs for SNAI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SNAI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SNAI1 35 34
  • 98.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SNAI1 35 34
  • 88.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SNAI1 35 34
  • 86.87 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Snai1 34
  • 85.23 (n)
mouse
(Mus musculus)
Mammalia Snai1 17 35 34
  • 84.97 (n)
oppossum
(Monodelphis domestica)
Mammalia SNAI1 35
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SNAI1 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves SNAI1 35
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SNAI1 35
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii snai1b 35
  • 47 (a)
OneToMany
snai1a 35
  • 45 (a)
OneToMany
-- 34
fruit fly
(Drosophila melanogaster)
Insecta sna 35 36
  • 26 (a)
ManyToMany
esg 35 36
  • 25 (a)
ManyToMany
wor 35 36
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea K02D7.2 35 36
  • 41 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8617 35
  • 45 (a)
OneToMany
Species where no ortholog for SNAI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SNAI1 Gene

ENSEMBL:
Gene Tree for SNAI1 (if available)
TreeFam:
Gene Tree for SNAI1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SNAI1: view image

Paralogs for SNAI1 Gene

(8) SIMAP similar genes for SNAI1 Gene using alignment to 1 proteins:

  • SNAI1_HUMAN

Pseudogenes.org Pseudogenes for SNAI1 Gene

genes like me logo Genes that share paralogs with SNAI1: view

Variants for SNAI1 Gene

Sequence variations from dbSNP and Humsavar for SNAI1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000245738 -- 49,981,313(+) G/A upstream_transcript_variant
rs1000704106 -- 49,982,464(+) T/C upstream_transcript_variant
rs1000770376 -- 49,988,381(+) G/A 3_prime_UTR_variant
rs1001031031 -- 49,981,869(+) C/A upstream_transcript_variant
rs1001091670 -- 49,982,376(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SNAI1 Gene

Variant ID Type Subtype PubMed ID
nsv1066927 CNV gain 25217958
nsv509776 CNV insertion 20534489

Variation tolerance for SNAI1 Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.45; 85.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SNAI1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SNAI1
Human Gene Mutation Database (HGMD)
SNAI1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SNAI1 Gene

Disorders for SNAI1 Gene

MalaCards: The human disease database

(19) MalaCards diseases for SNAI1 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
gastroesophageal junction adenocarcinoma
  • adenocarcinoma of cardioesophageal junction
fasciolopsiasis
  • infection by fasciolopsis buski
cercarial dermatitis
  • cutaneous schistosomiasis
dracunculiasis
  • dracontiasis
hemophagocytic lymphohistiocytosis, familial, 3
  • fhl3
- elite association - COSMIC cancer census association via MalaCards
Search SNAI1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SNAI1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with SNAI1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SNAI1 Gene

Publications for SNAI1 Gene

  1. Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P). (PMID: 10585766) Paznekas WA … Jabs EW (Genomics 1999) 2 3 4 58
  2. Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. (PMID: 25893292) Hwangbo C … Lee JH (Oncogene 2016) 3 4 58
  3. Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin β. (PMID: 24699649) Choi S … Lee SJ (Acta crystallographica. Section D, Biological crystallography 2014) 3 4 58
  4. Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. (PMID: 21952048) Zhang K … Longmore GD (The EMBO journal 2012) 3 4 58
  5. Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex. (PMID: 21300290) Baron R … Mattevi A (Structure (London, England : 1993) 2011) 3 4 58

Products for SNAI1 Gene

Sources for SNAI1 Gene

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