Aliases for SMYD3 Gene
External Ids for SMYD3 Gene
Previous HGNC Symbols for SMYD3 Gene
Previous GeneCards Identifiers for SMYD3 Gene
This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
GeneCards Summary for SMYD3 Gene
SMYD3 (SET And MYND Domain Containing 3) is a Protein Coding gene. Diseases associated with SMYD3 include Cerebellar Ataxia, Nonprogressive, With Mental Retardation and Renal Wilms' Tumor. Among its related pathways are Chromatin organization and Lysine degradation. Gene Ontology (GO) annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding and RNA polymerase II complex binding. An important paralog of this gene is SMYD2.
UniProtKB/Swiss-Prot Summary for SMYD3 Gene
Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates 'Lys-5' of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609).