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Aliases for SMTNL1 Gene

Aliases for SMTNL1 Gene

  • Smoothelin Like 1 2 3 5
  • Calponin Homology-Associated Smooth Muscle Protein 2 3
  • Smoothelin-Like Protein 1 3
  • CHASM 3

External Ids for SMTNL1 Gene

Previous GeneCards Identifiers for SMTNL1 Gene

  • GC11P057066
  • GC11P057309
  • GC11P053658

Summaries for SMTNL1 Gene

Entrez Gene Summary for SMTNL1 Gene

  • The protein encoded by this gene is involved in the contraction of both striated and smooth muscle. During pregnancy, the encoded protein interacts with progesterone receptor to attenuate the expression of contractile and metabolic proteins. [provided by RefSeq, Jul 2016]

GeneCards Summary for SMTNL1 Gene

SMTNL1 (Smoothelin Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calmodulin binding and protein phosphatase 1 binding. An important paralog of this gene is SMTN.

UniProtKB/Swiss-Prot for SMTNL1 Gene

  • Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity).

Additional gene information for SMTNL1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMTNL1 Gene

Genomics for SMTNL1 Gene

GeneHancer (GH) Regulatory Elements for SMTNL1 Gene

Promoters and enhancers for SMTNL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I057542 Promoter 0.6 EPDnew 550.4 +5.1 5109 0.1 ZIC2 SMTNL1 UBE2L6
GH11I057536 Enhancer 0.2 ENCODE 584.3 +1.0 1035 4.1 SMTNL1 TIMM10 UBE2L6
GH11I057513 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 33.5 -22.9 -22860 3.4 HDGF FOXA2 ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B SP3 SP5 SLC43A1 SMTNL1 TIMM10 GC11P057511
GH11I057547 Enhancer 0.9 Ensembl ENCODE 33.5 +10.2 10221 1.3 CTCF TFAP4 PKNOX1 SAP130 ARID4B EBF1 BATF IRF4 RAD21 ZNF600 SMTNL1 UBE2L6
GH11I057481 Enhancer 1 Ensembl ENCODE 20.6 -54.9 -54875 2.2 RB1 ZFP64 KLF17 SIN3A RAD21 GLIS2 ZNF366 ZNF143 RUNX3 SMARCA5 TIMM10 SMTNL1 RTN4RL2 RN7SKP259 SLC43A1 ENSG00000254979 SLC43A3 P2RX3 SSRP1 UBE2L6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SMTNL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SMTNL1 gene promoter:

Genomic Locations for SMTNL1 Gene

Genomic Locations for SMTNL1 Gene
12,723 bases
Plus strand

Genomic View for SMTNL1 Gene

Genes around SMTNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMTNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMTNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMTNL1 Gene

Proteins for SMTNL1 Gene

  • Protein details for SMTNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Smoothelin-like protein 1
    Protein Accession:

    Protein attributes for SMTNL1 Gene

    457 amino acids
    Molecular mass:
    48953 Da
    Quaternary structure:
    • Interacts with PPP1R12A.

neXtProt entry for SMTNL1 Gene

Post-translational modifications for SMTNL1 Gene

  • Maximal phosphorylation of Ser-299 correlates with maximal relaxation of aorta in response to acetylcholine.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMTNL1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMTNL1 Gene

Domains & Families for SMTNL1 Gene

Gene Families for SMTNL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SMTNL1 Gene

Suggested Antigen Peptide Sequences for SMTNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the smoothelin family.
  • Belongs to the smoothelin family.
genes like me logo Genes that share domains with SMTNL1: view

Function for SMTNL1 Gene

Molecular function for SMTNL1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-299 reduces this inhibitory activity (By similarity).

Phenotypes From GWAS Catalog for SMTNL1 Gene

Gene Ontology (GO) - Molecular Function for SMTNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005516 calmodulin binding IEA --
GO:0005523 tropomyosin binding IEA --
GO:0008157 protein phosphatase 1 binding IEA --
GO:0043621 protein self-association IEA --
GO:0051401 CH domain binding IEA --
genes like me logo Genes that share ontologies with SMTNL1: view
genes like me logo Genes that share phenotypes with SMTNL1: view

Animal Models for SMTNL1 Gene

MGI Knock Outs for SMTNL1:

Animal Model Products

miRNA for SMTNL1 Gene

miRTarBase miRNAs that target SMTNL1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SMTNL1 Gene

Localization for SMTNL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMTNL1 Gene

Cytoplasm, myofibril. Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line. Nucleus. Note=Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm (By similarity). Phosphorylation at Ser-301 promotes translocation to the nucleus (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMTNL1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for SMTNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0030016 myofibril IEA --
GO:0031430 M band IEA --
GO:0031674 I band IEA --
genes like me logo Genes that share ontologies with SMTNL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SMTNL1 Gene

Pathways & Interactions for SMTNL1 Gene

SuperPathways for SMTNL1 Gene

No Data Available

Interacting Proteins for SMTNL1 Gene

Selected Interacting proteins: A8MU46-SMTL1_HUMAN for SMTNL1 Gene via IID

Gene Ontology (GO) - Biological Process for SMTNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014823 response to activity IEA --
GO:0018105 peptidyl-serine phosphorylation IEA --
GO:0042493 response to drug IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
GO:0045907 positive regulation of vasoconstriction ISS --
genes like me logo Genes that share ontologies with SMTNL1: view

No data available for Pathways by source and SIGNOR curated interactions for SMTNL1 Gene

Drugs & Compounds for SMTNL1 Gene

No Compound Related Data Available

Transcripts for SMTNL1 Gene

mRNA/cDNA for SMTNL1 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMTNL1 Gene

Smoothelin-like 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMTNL1 Gene

No ASD Table

Relevant External Links for SMTNL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMTNL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMTNL1 Gene

mRNA differential expression in normal tissues according to GTEx for SMTNL1 Gene

This gene is overexpressed in Muscle - Skeletal (x46.6).

Protein differential expression in normal tissues from HIPED for SMTNL1 Gene

This gene is overexpressed in Tonsil (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SMTNL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SMTNL1 Gene:


SOURCE GeneReport for Unigene cluster for SMTNL1 Gene:


mRNA Expression by UniProt/SwissProt for SMTNL1 Gene:

Tissue specificity: Expressed in striated muscles, specifically in type 2a fibers (at protein level).

Evidence on tissue expression from TISSUES for SMTNL1 Gene

  • Muscle(3.3)
genes like me logo Genes that share expression patterns with SMTNL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMTNL1 Gene

Orthologs for SMTNL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMTNL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SMTNL1 33 34
  • 98.72 (n)
(Canis familiaris)
Mammalia SMTNL1 33 34
  • 79.49 (n)
(Rattus norvegicus)
Mammalia Smtnl1 33
  • 77.66 (n)
(Mus musculus)
Mammalia Smtnl1 33 16 34
  • 77.19 (n)
(Bos Taurus)
Mammalia SMTNL1 33 34
  • 74.62 (n)
(Monodelphis domestica)
Mammalia SMTNL1 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 12 (a)
(Gallus gallus)
Aves SMTNL1 34
  • 73 (a)
(Anolis carolinensis)
Reptilia SMTNL1 34
  • 43 (a)
(Danio rerio)
Actinopterygii smtna 34
  • 31 (a)
smtnl1 34
  • 24 (a)
(Caenorhabditis elegans)
Secernentea T15B12.1 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10261 34
  • 37 (a)
Species where no ortholog for SMTNL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SMTNL1 Gene

Gene Tree for SMTNL1 (if available)
Gene Tree for SMTNL1 (if available)

Paralogs for SMTNL1 Gene

(3) SIMAP similar genes for SMTNL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SMTNL1: view

Variants for SMTNL1 Gene

Sequence variations from dbSNP and Humsavar for SMTNL1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000044799 -- 57,547,623(+) G/A intron_variant
rs1000223759 -- 57,537,355(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000338301 -- 57,548,391(+) T/C intron_variant
rs1000588555 -- 57,535,744(+) C/T upstream_transcript_variant
rs1000645034 -- 57,542,327(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SMTNL1 Gene

Variant ID Type Subtype PubMed ID
nsv832163 CNV gain 17160897

Variation tolerance for SMTNL1 Gene

Gene Damage Index Score: 3.30; 53.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMTNL1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMTNL1 Gene

Disorders for SMTNL1 Gene

Additional Disease Information for SMTNL1

No disorders were found for SMTNL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMTNL1 Gene

Publications for SMTNL1 Gene

  1. Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. (PMID: 20634291) Lontay B … Haystead TA (The Journal of biological chemistry 2010) 3 4 58
  2. Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. (PMID: 18310078) Wooldridge AA … Haystead TA (The Journal of biological chemistry 2008) 3 4 58
  3. Modulation of smooth muscle contractility by CHASM, a novel member of the smoothelin family of proteins. (PMID: 15327999) Borman MA … Haystead TA (FEBS letters 2004) 2 3 58
  4. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
  5. Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice. (PMID: 26048986) Lontay B … Haystead TA (The Journal of biological chemistry 2015) 3 58

Products for SMTNL1 Gene

Sources for SMTNL1 Gene

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