Aliases for SMPDL3B Gene
External Ids for SMPDL3B Gene
Previous GeneCards Identifiers for SMPDL3B Gene
GeneCards Summary for SMPDL3B Gene
SMPDL3B (Sphingomyelin Phosphodiesterase Acid Like 3B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity and sphingomyelin phosphodiesterase activity. An important paralog of this gene is SMPDL3A.
UniProtKB/Swiss-Prot for SMPDL3B Gene
Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity).