Aliases for SMPD3 Gene
External Ids for SMPD3 Gene
Previous GeneCards Identifiers for SMPD3 Gene
GeneCards Summary for SMPD3 Gene
SMPD3 (Sphingomyelin Phosphodiesterase 3) is a Protein Coding gene. Diseases associated with SMPD3 include Pituitary Hormone Deficiency, Combined, 2 and Dentinogenesis Imperfecta. Among its related pathways are Sphingolipid metabolism and Ceramide Pathway. Gene Ontology (GO) annotations related to this gene include sphingomyelin phosphodiesterase activity.
UniProtKB/Swiss-Prot Summary for SMPD3 Gene
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity).