This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009] See more...

Aliases for SMPD2 Gene

Aliases for SMPD2 Gene

  • Sphingomyelin Phosphodiesterase 2 2 3 4 5
  • Neutral Sphingomyelinase 2 3 4
  • Lyso-Platelet-Activating Factor-Phospholipase C 3 4
  • Lyso-PAF-PLC 3 4
  • N-SMase 3 4
  • NSMase 2 4
  • ISC1 2 3
  • Sphingomyelin Phosphodiesterase 2, Neutral Membrane (Neutral Sphingomyelinase) 2
  • EC 3.1.4.12 4
  • NSMASE1 3
  • NSMase1 4
  • NSMASE 3
  • SMPD2 5

External Ids for SMPD2 Gene

Previous GeneCards Identifiers for SMPD2 Gene

  • GC06P109597
  • GC06P109784
  • GC06P109807
  • GC06P109868
  • GC06P109761
  • GC06P107328

Summaries for SMPD2 Gene

Entrez Gene Summary for SMPD2 Gene

  • This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]

GeneCards Summary for SMPD2 Gene

SMPD2 (Sphingomyelin Phosphodiesterase 2) is a Protein Coding gene. Diseases associated with SMPD2 include Lipid Storage Disease and Coffin-Siris Syndrome 1. Among its related pathways are Sphingolipid metabolism and p75(NTR)-mediated signaling. Gene Ontology (GO) annotations related to this gene include sphingomyelin phosphodiesterase activity.

UniProtKB/Swiss-Prot Summary for SMPD2 Gene

  • Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor).

Gene Wiki entry for SMPD2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SMPD2 Gene

Genomics for SMPD2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SMPD2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SMPD2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SMPD2

Top Transcription factor binding sites by QIAGEN in the SMPD2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • MyoD
  • NF-kappaB
  • NF-kappaB1

Genomic Locations for SMPD2 Gene

Latest Assembly
chr6:109,440,721-109,443,922
(GRCh38/hg38)
Size:
3,202 bases
Orientation:
Plus strand

Previous Assembly
chr6:109,761,927-109,765,122
(GRCh37/hg19 by Entrez Gene)
Size:
3,196 bases
Orientation:
Plus strand

chr6:109,761,966-109,765,122
(GRCh37/hg19 by Ensembl)
Size:
3,157 bases
Orientation:
Plus strand

Genomic View for SMPD2 Gene

Genes around SMPD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMPD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMPD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMPD2 Gene

Proteins for SMPD2 Gene

  • Protein details for SMPD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60906-NSMA_HUMAN
    Recommended name:
    Sphingomyelin phosphodiesterase 2
    Protein Accession:
    O60906
    Secondary Accessions:
    • Q5TED1
    • Q9BWR3

    Protein attributes for SMPD2 Gene

    Size:
    423 amino acids
    Molecular mass:
    47646 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for SMPD2 Gene

Post-translational modifications for SMPD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMPD2 Gene

No data available for DME Specific Peptides for SMPD2 Gene

Domains & Families for SMPD2 Gene

Gene Families for SMPD2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SMPD2 Gene

Suggested Antigen Peptide Sequences for SMPD2 Gene

GenScript: Design optimal peptide antigens:
  • Neutral sphingomyelinase (NSMA_HUMAN)
  • Sphingomyelin phosphodiesterase 2, neutral membrane (Neutral sphingomyelinase) (Q5TEC8_HUMAN)
  • Sphingomyelin phosphodiesterase 2, neutral membrane (Neutral sphingomyelinase) (Q5TEC9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60906

UniProtKB/Swiss-Prot:

NSMA_HUMAN :
  • Belongs to the neutral sphingomyelinase family.
Family:
  • Belongs to the neutral sphingomyelinase family.
genes like me logo Genes that share domains with SMPD2: view

Function for SMPD2 Gene

Molecular function for SMPD2 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Hydrolyze 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine; Xref=Rhea:RHEA:19253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639, ChEBI:CHEBI:295975; EC=3.1.4.12;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-octadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-octadecyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:39923, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74001, ChEBI:CHEBI:75216, ChEBI:CHEBI:295975; Evidence={ECO:0000269|PubMed:10608884, ECO:0000269|PubMed:14741383};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=an N-(acyl)-sphingosylphosphocholine + H2O = an N-acyl-sphingoid base + H(+) + phosphocholine; Xref=Rhea:RHEA:45300, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:64583, ChEBI:CHEBI:83273, ChEBI:CHEBI:295975; Evidence={ECO:0000269|PubMed:14741383};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:72998, ChEBI:CHEBI:75542, ChEBI:CHEBI:295975; Evidence={ECO:0000269|PubMed:14741383};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a sphingosylphosphocholine + H2O = a sphingoid base + H(+) + phosphocholine; Xref=Rhea:RHEA:45296, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:84410, ChEBI:CHEBI:85171, ChEBI:CHEBI:295975; Evidence={ECO:0000269|PubMed:14741383};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:36087, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:34115, ChEBI:CHEBI:64496, ChEBI:CHEBI:295975; Evidence={ECO:0000269|PubMed:10608884};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.5-7.5.;

Enzyme Numbers (IUBMB) for SMPD2 Gene

Phenotypes From GWAS Catalog for SMPD2 Gene

Gene Ontology (GO) - Molecular Function for SMPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004620 phospholipase activity IBA 21873635
GO:0004767 sphingomyelin phosphodiesterase activity IEA,IBA 21873635
GO:0005515 protein binding IPI 32296183
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SMPD2: view
genes like me logo Genes that share phenotypes with SMPD2: view

Animal Models for SMPD2 Gene

MGI Knock Outs for SMPD2:

Animal Models for research

  • Taconic Biosciences Mouse Models for SMPD2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMPD2

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SMPD2 Gene

Localization for SMPD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMPD2 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMPD2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
mitochondrion 3
cytosol 3
extracellular 2
cytoskeleton 2
nucleus 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SMPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9520418
GO:0005901 caveola IBA 21873635
GO:0016020 membrane IBA 21873635
genes like me logo Genes that share ontologies with SMPD2: view

Pathways & Interactions for SMPD2 Gene

genes like me logo Genes that share pathways with SMPD2: view

Pathways by source for SMPD2 Gene

7 Qiagen pathways for SMPD2 Gene
  • Caspase Cascade
  • Fas Signaling
  • LDL Oxidation in Atherogenesis
  • NGF Pathway
  • S-1P Stimulated Signaling
2 Cell Signaling Technology pathways for SMPD2 Gene

UniProtKB/Swiss-Prot O60906-NSMA_HUMAN

  • Pathway: Lipid metabolism; sphingolipid metabolism.

Gene Ontology (GO) - Biological Process for SMPD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006665 sphingolipid metabolic process IEA --
GO:0006684 sphingomyelin metabolic process TAS,IBA 21873635
GO:0006685 sphingomyelin catabolic process IEA --
GO:0006687 glycosphingolipid metabolic process TAS --
genes like me logo Genes that share ontologies with SMPD2: view

No data available for SIGNOR curated interactions for SMPD2 Gene

Drugs & Compounds for SMPD2 Gene

(13) Drugs for SMPD2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Water Approved Pharma 0
Ceramide NG Experimental Pharma 0

(154) Additional Compounds for SMPD2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphorylcholine
  • Choline phosphate
  • CHOP
  • N-Trimethyl-2-aminoethylphosphonate
  • O-Phosphocholine
  • Phosphoryl-choline
3616-04-4
3-O-Sulfogalactosylceramide (d18:1/12:0)
  • 3-O-Sulphogalactosylceramide (D18:1/12:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
852100-88-0
3-O-Sulfogalactosylceramide (d18:1/14:0)
  • 3-O-Sulphogalactosylceramide (D18:1/14:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
3-O-Sulfogalactosylceramide (d18:1/16:0)
  • 3-O-Sulphogalactosylceramide (D18:1/16:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
862509-48-6
3-O-Sulfogalactosylceramide (d18:1/18:0)
  • 3-O-Sulphogalactosylceramide (D18:1/18:0)
  • 3'-O-Sulphogalactosylceramide
  • 3-O-SulfO-beta-D-galactosylceramide
  • 3-O-SulfO-beta-delta-galactosylceramide
  • 3-O-Sulfogalactosylceramide
244215-65-4
genes like me logo Genes that share compounds with SMPD2: view

Transcripts for SMPD2 Gene

mRNA/cDNA for SMPD2 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMPD2

Alternative Splicing Database (ASD) splice patterns (SP) for SMPD2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: - - -
SP3: -
SP4: - -
SP5:
SP6: -

Relevant External Links for SMPD2 Gene

GeneLoc Exon Structure for
SMPD2

Expression for SMPD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SMPD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMPD2 Gene

This gene is overexpressed in Testis (x6.0).

Protein differential expression in normal tissues from HIPED for SMPD2 Gene

This gene is overexpressed in Nasal epithelium (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SMPD2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SMPD2

SOURCE GeneReport for Unigene cluster for SMPD2 Gene:

Hs.55235

Evidence on tissue expression from TISSUES for SMPD2 Gene

  • Nervous system(4.5)
  • Blood(2.3)
  • Skin(2.2)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with SMPD2: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMPD2 Gene

Orthologs for SMPD2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SMPD2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SMPD2 29 30
  • 99.37 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SMPD2 29 30
  • 87.47 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SMPD2 29 30
  • 86.05 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Smpd2 29
  • 83.18 (n)
Mouse
(Mus musculus)
Mammalia Smpd2 29 16 30
  • 81.86 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SMPD2 30
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SMPD2 29 30
  • 65.3 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SMPD2 30
  • 45 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia smpd2 29
  • 55.52 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC797914 29
  • 54.99 (n)
smpd2a 30
  • 41 (a)
OneToMany
SMPD2 (2 of 2) 30
  • 40 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008053 29
  • 51.21 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG12034 29 30 31
  • 48.27 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea T27F6.6 29 30 31
  • 49.83 (n)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ISC1 30 32
  • 22 (a)
OneToOne
Species where no ortholog for SMPD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SMPD2 Gene

ENSEMBL:
Gene Tree for SMPD2 (if available)
TreeFam:
Gene Tree for SMPD2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SMPD2: view image
Alliance of Genome Resources:
Additional Orthologs for SMPD2

Paralogs for SMPD2 Gene

No data available for Paralogs for SMPD2 Gene

Variants for SMPD2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SMPD2 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs370358389 Likely Benign: not provided 109,443,683(+) C/T
NM_003080.3(SMPD2):c.1050C>T (p.Ala350=)
SYNONYMOUS
rs527587528 Benign: not provided 109,442,830(+) G/C
NM_003080.3(SMPD2):c.570G>C (p.Leu190=)
SYNONYMOUS
rs1048197 -- p.Pro3Leu
rs1476387 -- p.Arg265Ser
rs9386806 -- p.Val223Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SMPD2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SMPD2 Gene

Variant ID Type Subtype PubMed ID
esv3576210 CNV gain 25503493
nsv950493 CNV deletion 24416366

Variation tolerance for SMPD2 Gene

Residual Variation Intolerance Score: 16.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.04; 80.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMPD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMPD2
Leiden Open Variation Database (LOVD)
SMPD2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMPD2 Gene

Disorders for SMPD2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for SMPD2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
lipid storage disease
  • inborn lipid storage disorder
coffin-siris syndrome 1
  • css1
neuroaspergillosis
farber lipogranulomatosis
  • frbrl
niemann-pick disease, type a
  • sphingomyelin lipidosis
- elite association - COSMIC cancer census association via MalaCards
Search SMPD2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SMPD2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SMPD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SMPD2 Gene

Publications for SMPD2 Gene

  1. Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling? (PMID: 9520418) Tomiuk S … Stoffel W (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 22
  2. Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. (PMID: 10608884) Sawai H … Hannun YA (The Journal of biological chemistry 1999) 3 4 22
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  4. Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin. (PMID: 19698806) Ito H … Murate T (Biochimica et biophysica acta 2009) 3 22
  5. Aggregated low density lipoprotein induces tissue factor by inhibiting sphingomyelinase activity in human vascular smooth muscle cells. (PMID: 19817993) Camino-López S … Llorente-Cortés V (Journal of thrombosis and haemostasis : JTH 2009) 3 22

Products for SMPD2 Gene

Sources for SMPD2 Gene