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This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
SMOC2 (SPARC Related Modular Calcium Binding 2) is a Protein Coding gene. Diseases associated with SMOC2 include Dentin Dysplasia, Type I and Dentin Dysplasia. Among its related pathways are Gastric Cancer Network 1. Gene Ontology (GO) annotations related to this gene include calcium ion binding and glycosaminoglycan binding. An important paralog of this gene is SMOC1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005509 | calcium ion binding | IEA,ISA | 12741954 |
GO:0005515 | protein binding | IEA | -- |
GO:0005539 | glycosaminoglycan binding | IEA | -- |
GO:0008201 | heparin binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA | -- |
GO:0005604 | basement membrane | IEA | -- |
GO:0005614 | interstitial matrix | IEA | -- |
GO:0005615 | extracellular space | IDA | 16774925 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gastric Cancer Network 1 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010595 | positive regulation of endothelial cell migration | IDA | 16774925 |
GO:0010811 | positive regulation of cell-substrate adhesion | IEA | -- |
GO:0030198 | extracellular matrix organization | IEA | -- |
GO:0035470 | positive regulation of vascular wound healing | IDA | 16774925 |
GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway | IDA | 16774925 |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||
SP3: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | SMOC2 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | SMOC2 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | SMOC2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | SMOC2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Smoc2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Smoc2 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | SMOC2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | SMOC2 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | SMOC2 (1 of 2) 31 |
|
OneToMany | |
SMOC2 (2 of 2) 31 |
|
OneToMany | |||
wufb75d10 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | magu 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | T04F3.2 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709829 | Likely Benign: not provided | 168,549,201(+) | C/T | MISSENSE_VARIANT | |
717704 | Benign: not provided | 168,650,739(+) | G/A | SYNONYMOUS_VARIANT | |
776186 | Benign: not provided | 168,653,098(+) | C/T | SYNONYMOUS_VARIANT | |
781761 | Likely Benign: not provided | 168,653,186(+) | G/A | MISSENSE_VARIANT | |
781890 | Benign: not provided | 168,664,103(+) | A/G | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
dentin dysplasia, type i |
|
|
dentin dysplasia |
|
|
type 1 diabetes mellitus 8 |
|
|
adenosquamous gallbladder carcinoma |
|
|
tooth agenesis |
|
|