Aliases for SMO Gene
External Ids for SMO Gene
Previous HGNC Symbols for SMO Gene
Previous GeneCards Identifiers for SMO Gene
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010]
GeneCards Summary for SMO Gene
SMO (Smoothened, Frizzled Class Receptor) is a Protein Coding gene. Diseases associated with SMO include Curry-Jones Syndrome and Pallister-Hall-Like Syndrome. Among its related pathways are Presynaptic function of Kainate receptors and Proteoglycans in cancer. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and PDZ domain binding. An important paralog of this gene is FZD3.
UniProtKB/Swiss-Prot Summary for SMO Gene
G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).
Smoothened (Smo) receptors are non-classical G-protein-coupled receptors that belong to the Frizzled family. Smoothened receptors lack the ability to directly interact with their endogenous ligand, Hedgehog (Hh). In the resting state, Smo receptors are bound to patched (Ptc).