Aliases for SMLR1 Gene

Aliases for SMLR1 Gene

  • Small Leucine Rich Protein 1 2 3 5
  • Small Leucine-Rich Protein 1 3 4

External Ids for SMLR1 Gene

Previous GeneCards Identifiers for SMLR1 Gene

  • GC06P131150

Summaries for SMLR1 Gene

GeneCards Summary for SMLR1 Gene

SMLR1 (Small Leucine Rich Protein 1) is a Protein Coding gene.

Additional gene information for SMLR1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SMLR1 Gene

Genomics for SMLR1 Gene

GeneHancer (GH) Regulatory Elements for SMLR1 Gene

Promoters and enhancers for SMLR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J130825 Promoter/Enhancer 1.6 EPDnew FANTOM5 Ensembl ENCODE 521.6 -0.4 -427 4.8 EP300 FOXK2 POLR2G NCOR1 TEAD4 KDM6A TCF7 ZBTB25 TGIF2 SKI SMLR1 AKAP7 piR-56759-502 EPB41L2
GH06J130966 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 16.2 +141.5 141518 4.4 ZSCAN5C SKI TEAD1 ATF2 TBX3 ZKSCAN8 ZSCAN9 KMT2B WT1 FOXA2 SMLR1 AKAP7 lnc-SAMD3-5 EPB41L2
GH06J130932 Enhancer 1.1 Ensembl ENCODE 17 +107.5 107496 9 EP300 FOXK2 ZNF217 TCF12 NCOR1 KDM6A TCF7 FOXA1 CUX1 ZBTB25 SMLR1 AKAP7 lnc-SAMD3-5 EPB41L2
GH06J130943 Enhancer 0.9 Ensembl ENCODE 17 +118.2 118235 4.7 NCOR1 TCF7 CTBP1 TEAD1 NR2F2 FOXA2 CEBPB SAP130 MAFK GATA3 SMLR1 AKAP7 lnc-SAMD3-5 EPB41L2
GH06J130980 Enhancer 0.9 Ensembl ENCODE dbSUPER 16.2 +154.2 154244 3.7 ZSCAN5C ZNF316 ZNF335 MAFK MAFG MAFF HLF ZNF202 HNRNPK PRDM10 SMLR1 AKAP7 lnc-SAMD3-5 EPB41L2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SMLR1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SMLR1

Genomic Locations for SMLR1 Gene

Genomic Locations for SMLR1 Gene
chr6:130,827,405-130,837,135
(GRCh38/hg38)
Size:
9,731 bases
Orientation:
Plus strand
chr6:131,148,546-131,158,275
(GRCh37/hg19)
Size:
9,730 bases
Orientation:
Plus strand

Genomic View for SMLR1 Gene

Genes around SMLR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMLR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMLR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMLR1 Gene

Proteins for SMLR1 Gene

  • Protein details for SMLR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    H3BR10-SMLR1_HUMAN
    Recommended name:
    Small leucine-rich protein 1
    Protein Accession:
    H3BR10

    Protein attributes for SMLR1 Gene

    Size:
    107 amino acids
    Molecular mass:
    12312 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMLR1 Gene

Post-translational modifications for SMLR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMLR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMLR1 Gene

Domains & Families for SMLR1 Gene

Gene Families for SMLR1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SMLR1 Gene

ProtoNet:
genes like me logo Genes that share domains with SMLR1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SMLR1 Gene

Function for SMLR1 Gene

Phenotypes From GWAS Catalog for SMLR1 Gene

Gene Ontology (GO) - Molecular Function for SMLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SMLR1: view

Phenotypes for SMLR1 Gene

genes like me logo Genes that share phenotypes with SMLR1: view

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMLR1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMLR1 Gene

Localization for SMLR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMLR1 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for SMLR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMLR1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for SMLR1 Gene

Pathways & Interactions for SMLR1 Gene

PathCards logo

SuperPathways for SMLR1 Gene

No Data Available

Interacting Proteins for SMLR1 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: H3BR10-SMLR1_HUMAN ENSP00000456026 for SMLR1 Gene via UniProtKB STRING IID

;

Gene Ontology (GO) - Biological Process for SMLR1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMLR1 Gene

Drugs & Compounds for SMLR1 Gene

No Compound Related Data Available

Transcripts for SMLR1 Gene

mRNA/cDNA for SMLR1 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMLR1

Alternative Splicing Database (ASD) splice patterns (SP) for SMLR1 Gene

No ASD Table

Relevant External Links for SMLR1 Gene

GeneLoc Exon Structure for
SMLR1

Expression for SMLR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SMLR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMLR1 Gene

This gene is overexpressed in Liver (x44.9).

Protein differential expression in normal tissues from HIPED for SMLR1 Gene

This gene is overexpressed in Gallbladder (30.4), Fetal Liver (26.3), and Liver (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SMLR1 Gene



Protein tissue co-expression partners for SMLR1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SMLR1

SOURCE GeneReport for Unigene cluster for SMLR1 Gene:

Hs.388715
genes like me logo Genes that share expression patterns with SMLR1: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMLR1 Gene

Orthologs for SMLR1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMLR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC746017 30
  • 99.38 (n)
cow
(Bos Taurus)
Mammalia SMLR1 30
  • 81.31 (n)
mouse
(Mus musculus)
Mammalia Smlr1 31
  • 65 (a)
OneToOne
Species where no ortholog for SMLR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMLR1 Gene

ENSEMBL:
Gene Tree for SMLR1 (if available)
TreeFam:
Gene Tree for SMLR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SMLR1: view image

Paralogs for SMLR1 Gene

No data available for Paralogs for SMLR1 Gene

Variants for SMLR1 Gene

Additional dbSNP identifiers (rs#s) for SMLR1 Gene

Variation tolerance for SMLR1 Gene

Gene Damage Index Score: 12.22; 94.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMLR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMLR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for SMLR1 Gene

Disorders for SMLR1 Gene

Additional Disease Information for SMLR1

No disorders were found for SMLR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMLR1 Gene

Publications for SMLR1 Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 54
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for SMLR1 Gene

Sources for SMLR1 Gene