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Aliases for SMIM7 Gene

Aliases for SMIM7 Gene

  • Small Integral Membrane Protein 7 2 3 5
  • C19orf42 3 4
  • Chromosome 19 Open Reading Frame 42 2
  • UPF0608 Protein C19orf42 3

External Ids for SMIM7 Gene

Previous HGNC Symbols for SMIM7 Gene

  • C19orf42

Previous GeneCards Identifiers for SMIM7 Gene

  • GC19M016742

Summaries for SMIM7 Gene

GeneCards Summary for SMIM7 Gene

SMIM7 (Small Integral Membrane Protein 7) is a Protein Coding gene. An important paralog of this gene is ENSG00000268790.

Additional gene information for SMIM7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM7 Gene

Genomics for SMIM7 Gene

GeneHancer (GH) Regulatory Elements for SMIM7 Gene

Promoters and enhancers for SMIM7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I016658 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 571.2 -0.2 -168 3.7 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B TMEM38A SMIM7 ENSG00000268790 GC19P020284 CHERP ENSG00000268743 ENSG00000269578 C19orf44 MED26 HAUS8
GH19I016063 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.3 +587.5 587529 18.7 CLOCK FEZF1 DMAP1 IRF4 E2F8 ZNF143 ZNF263 MCM3 SP3 MEF2D TPM4 AKAP8 CHERP ENSG00000269578 C19orf44 BRD4 ENSG00000267904 ENSG00000268087 SMIM7 MED26
GH19I016626 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 23.1 +31.9 31926 4.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ENSG00000141979 LOC105372296 MED26 SMIM7 C19orf44 ENSG00000269578 COLGALT1 HAUS8 CHERP SLC35E1
GH19I017336 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.2 -676.9 -676914 2.5 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 GTPBP3 CHERP ENSG00000269578 ENSG00000268743 IQCN COLGALT1 C19orf44 SIN3B HAUS8 MVB12A
GH19I017106 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 26.7 -448.7 -448748 4.4 HDGF ZNF493 ZFP64 SIN3A GLI4 ZNF2 IRF4 ZNF121 GLIS2 ZNF213 CHERP ENSG00000268743 ENSG00000269578 C19orf44 ENSG00000267904 ENSG00000268087 GTPBP3 SIN3B MYO9B SMIM7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SMIM7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SMIM7 Gene

Genomic Locations for SMIM7 Gene
chr19:16,630,743-16,660,442
(GRCh38/hg38)
Size:
29,700 bases
Orientation:
Minus strand
chr19:16,741,562-16,771,253
(GRCh37/hg19)

Genomic View for SMIM7 Gene

Genes around SMIM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM7 Gene

Proteins for SMIM7 Gene

  • Protein details for SMIM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ49-SMIM7_HUMAN
    Recommended name:
    Small integral membrane protein 7
    Protein Accession:
    Q9BQ49
    Secondary Accessions:
    • A8MX44

    Protein attributes for SMIM7 Gene

    Size:
    75 amino acids
    Molecular mass:
    8631 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM7 Gene

Post-translational modifications for SMIM7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SMIM7 Gene

Domains & Families for SMIM7 Gene

Gene Families for SMIM7 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for SMIM7 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SMIM7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQ49

UniProtKB/Swiss-Prot:

SMIM7_HUMAN :
  • Belongs to the SMIM7 family.
Family:
  • Belongs to the SMIM7 family.
genes like me logo Genes that share domains with SMIM7: view

Function for SMIM7 Gene

Phenotypes From GWAS Catalog for SMIM7 Gene

genes like me logo Genes that share phenotypes with SMIM7: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMIM7 Gene

Localization for SMIM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM7 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMIM7 gene
Compartment Confidence
extracellular 2
golgi apparatus 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SMIM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM7: view

Pathways & Interactions for SMIM7 Gene

SuperPathways for SMIM7 Gene

No Data Available

Interacting Proteins for SMIM7 Gene

Selected Interacting proteins: Q9BQ49-SMIM7_HUMAN for SMIM7 Gene via IID

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for SMIM7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM7 Gene

Drugs & Compounds for SMIM7 Gene

No Compound Related Data Available

Transcripts for SMIM7 Gene

Unigene Clusters for SMIM7 Gene

Small integral membrane protein 7:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM7 Gene

No ASD Table

Relevant External Links for SMIM7 Gene

GeneLoc Exon Structure for
SMIM7
ECgene alternative splicing isoforms for
SMIM7

Expression for SMIM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMIM7 Gene

Protein differential expression in normal tissues from HIPED for SMIM7 Gene

This gene is overexpressed in Nasal epithelium (58.6) and Bone (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SMIM7 Gene



Protein tissue co-expression partners for SMIM7 Gene

NURSA nuclear receptor signaling pathways regulating expression of SMIM7 Gene:

SMIM7

SOURCE GeneReport for Unigene cluster for SMIM7 Gene:

Hs.356467

Evidence on tissue expression from TISSUES for SMIM7 Gene

  • Lung(4.5)
  • Nervous system(3.9)
genes like me logo Genes that share expression patterns with SMIM7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM7 Gene

Orthologs for SMIM7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMIM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf42 33
  • 99.11 (n)
-- 34
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia C19ORF42 34
  • 96 (a)
OneToMany
SMIM7 33
  • 93.78 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 95 (a)
OneToMany
SMIM7 33
  • 93.78 (n)
rat
(Rattus norvegicus)
Mammalia Smim7 33
  • 86.67 (n)
mouse
(Mus musculus)
Mammalia Smim7 33 16 34
  • 85.78 (n)
chicken
(Gallus gallus)
Aves C28H19ORF42 33
  • 79.56 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia smim7 33
  • 76.89 (n)
zebrafish
(Danio rerio)
Actinopterygii smim7 34 33
  • 74.22 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 72 (a)
OneToMany
Species where no ortholog for SMIM7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMIM7 Gene

ENSEMBL:
Gene Tree for SMIM7 (if available)
TreeFam:
Gene Tree for SMIM7 (if available)

Paralogs for SMIM7 Gene

Paralogs for SMIM7 Gene

Pseudogenes.org Pseudogenes for SMIM7 Gene

genes like me logo Genes that share paralogs with SMIM7: view

Variants for SMIM7 Gene

Sequence variations from dbSNP and Humsavar for SMIM7 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000135279 -- 16,662,033(-) C/T upstream_transcript_variant
rs1000246092 -- 16,656,606(-) A/T intron_variant
rs1000395429 -- 16,650,839(-) G/C genic_downstream_transcript_variant, intron_variant
rs1000402060 -- 16,661,759(-) G/A upstream_transcript_variant
rs1000414602 -- 16,645,363(-) C/G/T genic_downstream_transcript_variant, intron_variant

Variation tolerance for SMIM7 Gene

Residual Variation Intolerance Score: 54.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMIM7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SMIM7 Gene

Disorders for SMIM7 Gene

Additional Disease Information for SMIM7

No disorders were found for SMIM7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM7 Gene

Publications for SMIM7 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Initial characterization of the human central proteome. (PMID: 21269460) Burkard TR … Colinge J (BMC systems biology 2011) 4 58
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for SMIM7 Gene

Sources for SMIM7 Gene

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