Aliases for SMIM6 Gene

Aliases for SMIM6 Gene

  • Small Integral Membrane Protein 6 2 3 4 5
  • Endoregulin 2 3
  • C17orf110 3 4
  • ELN 2 3
  • Chromosome 17 Open Reading Frame 110 2
  • SMIM6 5

External Ids for SMIM6 Gene

Previous HGNC Symbols for SMIM6 Gene

  • C17orf110

Previous GeneCards Identifiers for SMIM6 Gene

  • GC17P073645

Summaries for SMIM6 Gene

GeneCards Summary for SMIM6 Gene

SMIM6 (Small Integral Membrane Protein 6) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SMIM6 Gene

Genomics for SMIM6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SMIM6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SMIM6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SMIM6

Genomic Locations for SMIM6 Gene

Latest Assembly
1,733 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
1,724 bases
Plus strand

(GRCh37/hg19 by Ensembl)
1,735 bases
Plus strand

Genomic View for SMIM6 Gene

Genes around SMIM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM6 Gene

Proteins for SMIM6 Gene

  • Protein details for SMIM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small integral membrane protein 6
    Protein Accession:

    Protein attributes for SMIM6 Gene

    62 amino acids
    Molecular mass:
    7017 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM6 Gene

Post-translational modifications for SMIM6 Gene

No Post-translational modifications

Other Protein References for SMIM6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM6 Gene

Domains & Families for SMIM6 Gene

Gene Families for SMIM6 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SMIM6 Gene

genes like me logo Genes that share domains with SMIM6: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SMIM6 Gene

Function for SMIM6 Gene

Phenotypes From GWAS Catalog for SMIM6 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMIM6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMIM6 Gene

Localization for SMIM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM6 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SMIM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM6: view

No data available for Subcellular locations from COMPARTMENTS for SMIM6 Gene

Pathways & Interactions for SMIM6 Gene

PathCards logo

SuperPathways for SMIM6 Gene

No Data Available

Interacting Proteins for SMIM6 Gene

Gene Ontology (GO) - Biological Process for SMIM6 Gene


No data available for Pathways by source and SIGNOR curated interactions for SMIM6 Gene

Drugs & Compounds for SMIM6 Gene

No Compound Related Data Available

Transcripts for SMIM6 Gene

mRNA/cDNA for SMIM6 Gene

4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMIM6

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM6 Gene

No ASD Table

Relevant External Links for SMIM6 Gene

GeneLoc Exon Structure for

Expression for SMIM6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SMIM6 Gene

mRNA differential expression in normal tissues according to GTEx for SMIM6 Gene

This gene is overexpressed in Testis (x11.6), Stomach (x7.4), and Kidney - Cortex (x7.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SMIM6

SOURCE GeneReport for Unigene cluster for SMIM6 Gene:

genes like me logo Genes that share expression patterns with SMIM6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM6 Gene

Orthologs for SMIM6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMIM6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C17H17orf110 30
  • 100 (n)
(Bos Taurus)
Mammalia SMIM6 31
  • 56 (a)
Species where no ortholog for SMIM6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SMIM6 Gene

Gene Tree for SMIM6 (if available)
Gene Tree for SMIM6 (if available)
Evolutionary constrained regions (ECRs) for SMIM6: view image

Paralogs for SMIM6 Gene

No data available for Paralogs for SMIM6 Gene

Variants for SMIM6 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SMIM6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SMIM6 Gene

Variant ID Type Subtype PubMed ID
nsv470603 CNV loss 18288195
nsv516133 CNV loss 19592680
nsv576027 CNV gain 21841781
nsv833543 CNV loss 17160897
nsv833544 CNV loss 17160897

Variation tolerance for SMIM6 Gene

Gene Damage Index Score: 0.36; 7.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMIM6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SMIM6 Gene

Disorders for SMIM6 Gene

Additional Disease Information for SMIM6

No disorders were found for SMIM6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM6 Gene

Publications for SMIM6 Gene

  1. Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides. (PMID: 27923914) Anderson DM … Olson EN (Science signaling 2016) 3
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
  5. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3

Products for SMIM6 Gene

Sources for SMIM6 Gene