Aliases for SMIM5 Gene
Aliases for SMIM5 Gene
External Ids for SMIM5 Gene
- HGNC: 40030
- Entrez Gene: 643008
- Ensembl: ENSG00000204323
- UniProtKB: Q71RC9
Previous HGNC Symbols for SMIM5 Gene
- C17orf109
Previous GeneCards Identifiers for SMIM5 Gene
- GC17P073632
Summaries for SMIM5 Gene
GeneCards Summary for SMIM5 Gene
SMIM5 (Small Integral Membrane Protein 5) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM5 Gene
Genomics for SMIM5 Gene
GeneHancer (GH) Regulatory Elements for SMIM5 Gene
Promoters and enhancers for SMIM5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around SMIM5 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SMIM5 Gene
Genomic Locations for SMIM5 Gene
- chr17:75,633,434-75,641,406
- (GRCh38/hg38)
- Size:
- 7,973 bases
- Orientation:
- Plus strand
- chr17:73,629,514-73,637,486
- (GRCh37/hg19)
- Size:
- 7,973 bases
- Orientation:
- Plus strand
Genomic View for SMIM5 Gene
Genes around SMIM5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by Entrez Gene
- 17q25.1 by HGNC
- 17q25.1 by Ensembl
SMIM5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SMIM5 Gene
Proteins for SMIM5 Gene
-
Protein details for SMIM5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q71RC9-SMIM5_HUMAN
- Recommended name:
- Small integral membrane protein 5
- Protein Accession:
- Q71RC9
Protein attributes for SMIM5 Gene
- Size:
- 77 amino acids
- Molecular mass:
- 8540 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAQ15244.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=EAW89296.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for SMIM5 Gene
Post-translational modifications for SMIM5 Gene
No Post-translational modifications
Other Protein References for SMIM5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SMIM5
- Invitrogen Antibodies for SMIM5
- Search GeneTex for Antibodies for SMIM5
Protein Products
-
OriGene Purified Proteins for SMIM5
- Search Origene for MassSpec and Protein Over-expression Lysates for SMIM5
- Origene Custom Protein Services for SMIM5
- Novus Biologicals proteins for SMIM5
- Search GeneTex for Proteins for SMIM5
Assay Products
No data available for DME Specific Peptides for SMIM5 Gene
Domains & Families for SMIM5 Gene
Gene Families for SMIM5 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Graphical View of Domain Structure for InterPro Entry
No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SMIM5 Gene
Function for SMIM5 Gene
Phenotypes From GWAS Catalog for SMIM5 Gene
Phenotypes for SMIM5 Gene
- GenomeRNAi human phenotypes for SMIM5:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SMIM5
-
CRISPR Products
- Browse CRISPR knockouts for SMIM5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SMIM5
- genomics-online: gRNA clones - Search results for available SMIM5 gene related products
- Applied Biological Materials CRISPR for SMIM5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SMIM5
- GenScript: Design CRISPR guide RNA sequences for SMIM5
miRNA Products
Inhibitory RNA Products
- Origene sirna and RNAi products in human, mouse, rat for SMIM5
- Browse OriGene Inhibitory RNA Products For SMIM5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMIM5
- genomics-online: shRNA clones - Search results for available SMIM5 gene related products
Clone Products
- Sino Biological Human cDNA Clone for SMIM5
- VectorBuilder custom plasmid, inducible vectors for SMIM5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SMIM5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SMIM5
- genomics-online: cdna clones - Search results for available SMIM5 gene related products
- orf clones - Search results for available SMIM5 gene related products
- Applied Biological Materials Clones for SMIM5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SMIM5
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMIM5 Gene
Localization for SMIM5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SMIM5 Gene
- Membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 2 |
| extracellular | 1 |
- Golgi apparatus (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for SMIM5 Gene
No Data Available
Interacting Proteins for SMIM5 Gene
No data available for Pathways by source and SIGNOR curated interactions for SMIM5 Gene
Transcripts for SMIM5 Gene
mRNA/cDNA for SMIM5 Gene
- (9) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000375215 1546 bps (uc002jow.3)
- ENST00000581115 662 bps (uc060kad.1)
- ENST00000537494 4344 bps (uc060kae.1)
Unigene Clusters for SMIM5 Gene
- Small integral membrane protein 5:
- Representative Sequences:
CRISPR Products
- Browse CRISPR knockouts for SMIM5
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SMIM5
- genomics-online: gRNA clones - Search results for available SMIM5 gene related products
- Applied Biological Materials CRISPR for SMIM5
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SMIM5
- GenScript: Design CRISPR guide RNA sequences for SMIM5
miRNA Products
Inhibitory RNA Products
- Origene sirna and RNAi products in human, mouse, rat for SMIM5
- Browse OriGene Inhibitory RNA Products For SMIM5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMIM5
- genomics-online: shRNA clones - Search results for available SMIM5 gene related products
Clone Products
- Sino Biological Human cDNA Clone for SMIM5
- VectorBuilder custom plasmid, inducible vectors for SMIM5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SMIM5
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SMIM5
- genomics-online: cdna clones - Search results for available SMIM5 gene related products
- orf clones - Search results for available SMIM5 gene related products
- Applied Biological Materials Clones for SMIM5
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SMIM5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
-
Ovary (Reproductive System)
- Pre-Granulosa Cells Primordial Follicle
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for SMIM5 Gene
This gene is overexpressed in Esophagus - Mucosa (x4.8).
This gene is overexpressed in Platelet (27.8), Urine (20.5), and Bone (18.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SMIM5 Gene
NURSA nuclear receptor signaling pathways regulating expression of SMIM5 Gene:
SMIM5SOURCE GeneReport for Unigene cluster for SMIM5 Gene:
Hs.528605Primer Products
- genomics-online: primer clones - Search results for available SMIM5 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM5 Gene
Orthologs for SMIM5 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C17H17orf109 33 |
|
||
| SMIM5 34 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | SMIM5 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Smim5 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | SMIM5 34 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SMIM5 34 |
|
OneToOne |
- Species where no ortholog for SMIM5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for SMIM5 Gene
- ENSEMBL:
- Gene Tree for SMIM5 (if available)
- TreeFam:
- Gene Tree for SMIM5 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SMIM5: view image
Paralogs for SMIM5 Gene
No data available for Paralogs for SMIM5 Gene
Variants for SMIM5 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000045499 | -- | 75,632,266(+) | G/A | upstream_transcript_variant | |
| rs1000059605 | -- | 75,635,014(+) | C/T | 3_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000333509 | -- | 75,640,066(+) | T/C | 5_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant | |
| rs1000872473 | -- | 75,638,650(+) | GGGGGGG/GGGGGGGG | downstream_transcript_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant, upstream_transcript_variant | |
| rs1001378645 | -- | 75,639,686(+) | G/A | 5_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant |
Gene Damage Index Score:
1.01;
20.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SMIM5 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SMIM5
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM5 Gene
Disorders for SMIM5 Gene
Additional Disease Information for SMIM5
No disorders were found for SMIM5 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM5 Gene
Publications for SMIM5 Gene
- FUT11 as a potential biomarker of clear cell renal cell carcinoma progression based on meta-analysis of gene expression data. (PMID: 24318988) Zodro E … Wesoly J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014) 2 3 58
- A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. (PMID: 28065597) Yao Z … Stagljar I (Molecular cell 2017) 3 58
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
- Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107410) Wistow G … Peterson K (Molecular vision 2002) 3 58
Products for SMIM5 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Proteome Profiler Antibody Arrays
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- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SMIM5
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- Browse OriGene qPCR primer pairs and template standards
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- OriGene ORF clones in human for SMIM5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for SMIM5 in any vector
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- Browse Antibodies
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- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for SMIM5
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SMIM5
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available SMIM5 related products ranked by validation data
- antibodies-online: Search results for available SMIM5 related products ranked by validation data
- antibodies-online: Search results for available SMIM5 related products ranked by validation data
- Search GeneTex for Antibodies for SMIM5
- Search GeneTex for Proteins for SMIM5
- Horizon Cell Lines for SMIM5
- genomics-online: cdna clones - Search results for available SMIM5 gene related products
- orf clones - Search results for available SMIM5 gene related products
- genomics-online: gRNA clones - Search results for available SMIM5 gene related products
- genomics-online: primer clones - Search results for available SMIM5 gene related products
- genomics-online: shRNA clones - Search results for available SMIM5 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SMIM5
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SMIM5
- GeneCopoeia miRNA 3'UTR Target clone products for SMIM5
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMIM5
Sources for SMIM5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt