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Aliases for SMIM3 Gene

Aliases for SMIM3 Gene

  • Small Integral Membrane Protein 3 2 3 5
  • NGF-Induced Differentiation Clone 67 Protein 3 4
  • Small Membrane Protein NID67 3 4
  • C5orf62 3 4
  • NID67 3 4
  • Chromosome 5 Open Reading Frame 62 2
  • Uncharacterized Protein C5orf62 3
  • MST150 3

External Ids for SMIM3 Gene

Previous HGNC Symbols for SMIM3 Gene

  • C5orf62

Previous GeneCards Identifiers for SMIM3 Gene

  • GC05P150159

Summaries for SMIM3 Gene

GeneCards Summary for SMIM3 Gene

SMIM3 (Small Integral Membrane Protein 3) is a Protein Coding gene.

Additional gene information for SMIM3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM3 Gene

Genomics for SMIM3 Gene

GeneHancer (GH) Regulatory Elements for SMIM3 Gene

Promoters and enhancers for SMIM3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I150777 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 560.9 +3.2 3171 8.1 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 IRF4 SMIM3 RPL7P1 RBM22 TCOF1 HMGXB3 G3BP1 ZNF300 TNIP1 RPS14 CCDC69
GH05I149956 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 -818.3 -818297 6.7 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 SLC26A2 PDE6A HMGXB3 TCOF1 ZNF300 ZNF300P1 TIGD6 RPL7P1 CSNK1A1 RPS20P4
GH05I151074 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 +303.3 303326 13.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 TNIP1 ZNF300P1 TCOF1 G3BP1 ANXA6 RPL7P1 ZNF300 RPS14 SMIM3 PDGFRB
GH05I150756 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.8 -19.6 -19566 3.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 DCTN4 TCOF1 SMIM3 HMGXB3 ZNF300P1 CCDC69 RPL7P1 RPS14 PIR34076
GH05I151769 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.5 +994.5 994541 5.2 PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A G3BP1 ATOX1 GC05M151769 LOC100652758 RPLP1P6 SMIM3 SPARC CCDC69 LOC105378231
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SMIM3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SMIM3 Gene

Genomic Locations for SMIM3 Gene
chr5:150,777,946-150,796,736
(GRCh38/hg38)
Size:
18,791 bases
Orientation:
Plus strand
chr5:150,157,508-150,176,298
(GRCh37/hg19)

Genomic View for SMIM3 Gene

Genes around SMIM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM3 Gene

Proteins for SMIM3 Gene

  • Protein details for SMIM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZL3-SMIM3_HUMAN
    Recommended name:
    Small integral membrane protein 3
    Protein Accession:
    Q9BZL3
    Secondary Accessions:
    • Q3MIG3
    • Q6ZUV4

    Protein attributes for SMIM3 Gene

    Size:
    60 amino acids
    Molecular mass:
    6593 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI01839.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAI01841.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAI06041.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAC86114.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=EAW61705.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SMIM3 Gene

Post-translational modifications for SMIM3 Gene

No Post-translational modifications

Other Protein References for SMIM3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM3 Gene

Domains & Families for SMIM3 Gene

Gene Families for SMIM3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SMIM3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SMIM3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM3: view

No data available for UniProtKB/Swiss-Prot for SMIM3 Gene

Function for SMIM3 Gene

Molecular function for SMIM3 Gene

UniProtKB/Swiss-Prot Induction:
By NGF.

Phenotypes From GWAS Catalog for SMIM3 Gene

Gene Ontology (GO) - Molecular Function for SMIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SMIM3: view

Phenotypes for SMIM3 Gene

genes like me logo Genes that share phenotypes with SMIM3: view

Animal Models for SMIM3 Gene

MGI Knock Outs for SMIM3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SMIM3

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SMIM3 Gene

Localization for SMIM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SMIM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM3: view

No data available for Subcellular locations from COMPARTMENTS for SMIM3 Gene

Pathways & Interactions for SMIM3 Gene

SuperPathways for SMIM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SMIM3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM3 Gene

Drugs & Compounds for SMIM3 Gene

No Compound Related Data Available

Transcripts for SMIM3 Gene

mRNA/cDNA for SMIM3 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(186) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SMIM3 Gene

Small integral membrane protein 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM3 Gene

No ASD Table

Relevant External Links for SMIM3 Gene

GeneLoc Exon Structure for
SMIM3
ECgene alternative splicing isoforms for
SMIM3

Expression for SMIM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMIM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SMIM3 Gene:

SMIM3

SOURCE GeneReport for Unigene cluster for SMIM3 Gene:

Hs.29444

Evidence on tissue expression from TISSUES for SMIM3 Gene

  • Intestine(4)
  • Pancreas(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with SMIM3: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM3 Gene

Orthologs for SMIM3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMIM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMIM3 33 34
  • 99.44 (n)
dog
(Canis familiaris)
Mammalia SMIM3 33 34
  • 90 (n)
cow
(Bos Taurus)
Mammalia MGC128424 34 33
  • 87.22 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Smim3 33 16 34
  • 84.75 (n)
rat
(Rattus norvegicus)
Mammalia Smim3 33
  • 83.33 (n)
oppossum
(Monodelphis domestica)
Mammalia SMIM3 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SMIM3 34
  • 68 (a)
OneToOne
Species where no ortholog for SMIM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM3 Gene

ENSEMBL:
Gene Tree for SMIM3 (if available)
TreeFam:
Gene Tree for SMIM3 (if available)

Paralogs for SMIM3 Gene

No data available for Paralogs for SMIM3 Gene

Variants for SMIM3 Gene

Sequence variations from dbSNP and Humsavar for SMIM3 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000260503 -- 150,796,403(+) G/A/C/T 3_prime_UTR_variant
rs1000282995 -- 150,778,323(+) G/C 5_prime_UTR_variant
rs1000406452 -- 150,782,461(+) C/T intron_variant
rs1000448542 -- 150,788,173(+) C/G intron_variant
rs1000467326 -- 150,784,372(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SMIM3 Gene

Variant ID Type Subtype PubMed ID
dgv10114n54 CNV loss 21841781
dgv5817n100 CNV loss 25217958
dgv5818n100 CNV loss 25217958
esv2759386 CNV loss 17122850
nsv428129 CNV loss 18775914
nsv435820 CNV deletion 17901297
nsv5067 CNV deletion 18451855
nsv950426 CNV duplication 24416366

Variation tolerance for SMIM3 Gene

Residual Variation Intolerance Score: 74.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.01; 50.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMIM3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM3 Gene

Disorders for SMIM3 Gene

Additional Disease Information for SMIM3

No disorders were found for SMIM3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM3 Gene

Publications for SMIM3 Gene

  1. NID67, a small putative membrane protein, is preferentially induced by NGF in PC12 pheochromocytoma cells. (PMID: 11288140) Vician L … Herschman HR (Journal of neuroscience research 2001) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual JF … Vidal M (Nature 2005) 3 58

Products for SMIM3 Gene

Sources for SMIM3 Gene

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