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Aliases for SMIM29 Gene

Aliases for SMIM29 Gene

  • Small Integral Membrane Protein 29 2 3 5
  • C6orf1 3 4
  • LBH 3 4
  • Chromosome 6 Open Reading Frame 1 2
  • Uncharacterized Protein C6orf1 3
  • Uncharacterized Protein SMIM29 3
  • Protein LBH 4

External Ids for SMIM29 Gene

Previous HGNC Symbols for SMIM29 Gene

  • C6orf1

Previous GeneCards Identifiers for SMIM29 Gene

  • GC06M037394
  • GC06M037751
  • GC06M038098

Summaries for SMIM29 Gene

GeneCards Summary for SMIM29 Gene

SMIM29 (Small Integral Membrane Protein 29) is a Protein Coding gene.

Additional gene information for SMIM29 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMIM29 Gene

Genomics for SMIM29 Gene

GeneHancer (GH) Regulatory Elements for SMIM29 Gene

Promoters and enhancers for SMIM29 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J034233 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 656.9 +7.2 7214 17.1 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SMIM29 MIR6835 HMGA1 LEMD2 VPS52 WDR46 DAXX TAF11 RGL2 HCG25
GH06J033423 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +822.5 822485 6 HDGF PKNOX1 SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 DAXX LEMD2 BRD2 WDR46 RGL2 RXRB VPS52 SYNGAP1 KIFC1 RPS10
GH06J034670 Enhancer 1.5 Ensembl ENCODE dbSUPER 11.6 -423.8 -423838 6.3 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B FEZF1 DMAP1 UHRF1BP1 SMIM29 GC06M038525 RN7SL200P C6orf106 GC06P043158
GH06J033430 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 11.6 +817.1 817050 4.5 HDGF ATF1 FOXA2 ARID4B SIN3A ZNF48 ETS1 GLIS2 ELK1 ZNF143 RING1 HCG25 ZBTB9 DAXX PHF1 SYNGAP1 LOC105375022 LEMD2 VPS52 SMIM29
GH06J034068 Enhancer 0.9 dbSUPER 11.7 +179.0 179042 4.3 ZNF473 NFIB ZSCAN4 INSM2 YBX1 PLRG1 ZNF416 ZNF207 ZNF548 MCM5 RING1 TAF11 HCG25 LEMD2 VPS52 RXRB DAXX PHF1 ITPR3 KIFC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SMIM29 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SMIM29 Gene

Genomic Locations for SMIM29 Gene
chr6:34,246,380-34,249,470
(GRCh38/hg38)
Size:
3,091 bases
Orientation:
Minus strand
chr6:34,214,157-34,217,247
(GRCh37/hg19)
Size:
3,091 bases
Orientation:
Minus strand

Genomic View for SMIM29 Gene

Genes around SMIM29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM29 Gene

Proteins for SMIM29 Gene

  • Protein details for SMIM29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T20-SIM29_HUMAN
    Recommended name:
    Small integral membrane protein 29
    Protein Accession:
    Q86T20
    Secondary Accessions:
    • A0A1C7CYX6
    • A8K299

    Protein attributes for SMIM29 Gene

    Size:
    102 amino acids
    Molecular mass:
    11550 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH23627.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH47919.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=BAF82853.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=EAX03775.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for SMIM29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMIM29 Gene

Post-translational modifications for SMIM29 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SMIM29 Gene

Domains & Families for SMIM29 Gene

Gene Families for SMIM29 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SMIM29 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SMIM29 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SMIM29: view

No data available for UniProtKB/Swiss-Prot for SMIM29 Gene

Function for SMIM29 Gene

Phenotypes From GWAS Catalog for SMIM29 Gene

genes like me logo Genes that share phenotypes with SMIM29: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMIM29 Gene

Localization for SMIM29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM29 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMIM29 gene
Compartment Confidence
extracellular 4
mitochondrion 2
plasma membrane 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SMIM29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM29: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SMIM29 Gene

Pathways & Interactions for SMIM29 Gene

SuperPathways for SMIM29 Gene

No Data Available

Interacting Proteins for SMIM29 Gene

Selected Interacting proteins: Q86T20-SIM29_HUMAN for SMIM29 Gene via IID

Symbol External ID(s) Details
HMGA1

Gene Ontology (GO) - Biological Process for SMIM29 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM29 Gene

Drugs & Compounds for SMIM29 Gene

No Compound Related Data Available

Transcripts for SMIM29 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM29 Gene

No ASD Table

Relevant External Links for SMIM29 Gene

GeneLoc Exon Structure for
SMIM29
ECgene alternative splicing isoforms for
SMIM29

Expression for SMIM29 Gene

NURSA nuclear receptor signaling pathways regulating expression of SMIM29 Gene:

SMIM29

mRNA Expression by UniProt/SwissProt for SMIM29 Gene:

Q86T20-SIM29_HUMAN
Tissue specificity: Expressed in spleen, thymus, prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for SMIM29 Gene

  • Nervous system(4.3)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM29 Gene

Orthologs for SMIM29 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMIM29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C6H6orf1 33
  • 99.78 (n)
C6orf1 34
  • 99 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7226 33
zebrafish
(Danio rerio)
Actinopterygii Dr.3972 33
Species where no ortholog for SMIM29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SMIM29 Gene

ENSEMBL:
Gene Tree for SMIM29 (if available)
TreeFam:
Gene Tree for SMIM29 (if available)

Paralogs for SMIM29 Gene

No data available for Paralogs for SMIM29 Gene

Variants for SMIM29 Gene

Sequence variations from dbSNP and Humsavar for SMIM29 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000396258 -- 34,246,423(-) A/G 3_prime_UTR_variant
rs1001219180 -- 34,249,371(-) C/G upstream_transcript_variant
rs1001314162 -- 34,249,913(-) C/T upstream_transcript_variant
rs1002157975 -- 34,246,927(-) C/T intron_variant
rs1003898503 -- 34,249,875(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SMIM29 Gene

Variant ID Type Subtype PubMed ID
nsv602863 CNV loss 21841781
nsv602865 CNV loss 21841781
nsv969388 CNV duplication 23825009

Variation tolerance for SMIM29 Gene

Residual Variation Intolerance Score: 71.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMIM29 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMIM29 Gene

Disorders for SMIM29 Gene

No disorders were found for SMIM29 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM29 Gene

Publications for SMIM29 Gene

  1. Assignment of a new gene (LBH). (PMID: 10036196) Kazmierczak B … Bullerdiek J (Genomics 1999) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X … REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology Donor Study-II Component International (PloS one 2013) 3 58
  4. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A … Haiman CA (PLoS genetics 2011) 3 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58

Products for SMIM29 Gene

Sources for SMIM29 Gene

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