Aliases for SMIM2 Gene

Aliases for SMIM2 Gene

  • Small Integral Membrane Protein 2 2 3 4 5
  • C13orf44 3 4
  • Chromosome 13 Open Reading Frame 44 2

External Ids for SMIM2 Gene

Previous HGNC Symbols for SMIM2 Gene

  • C13orf44

Previous GeneCards Identifiers for SMIM2 Gene

  • GC13M044723

Summaries for SMIM2 Gene

GeneCards Summary for SMIM2 Gene

SMIM2 (Small Integral Membrane Protein 2) is a Protein Coding gene.

Additional gene information for SMIM2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SMIM2 Gene

Genomics for SMIM2 Gene

GeneHancer (GH) Regulatory Elements for SMIM2 Gene

Promoters and enhancers for SMIM2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J044157 Enhancer 0.9 ENCODE dbSUPER 500.7 +1.5 1462 3.9 TCF12 RFX1 EP300 CTBP1 BRCA1 FOS FOSL2 CEBPB NEUROD1 JUN SMIM2 SMIM2-IT1 SMIM2-AS1
GH13J044300 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10.6 -146.2 -146227 14.8 TCF12 JUND FOS ZNF10 ZIC2 REST POLR2A TCF7 RELA EP300 lnc-SERP2-15 SERP2 LACC1 GPALPP1 SMIM2 SMIM2-IT1 SMIM2-AS1 CCDC122 TSC22D1 lnc-SERP2-5
GH13J044191 Enhancer 1.2 Ensembl ENCODE dbSUPER 12 -31.3 -31275 2.9 CTCF ZSCAN5C MYC TEAD4 TRIM28 REST RFX1 RAD21 TEAD1 SMC3 GPALPP1 SMIM2 SMIM2-IT1 SMIM2-AS1 TSC22D1 ENSG00000276854
GH13J044218 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.6 -58.8 -58796 3.5 ZSCAN5C TCF12 FOS KLF7 FOXA2 OSR2 WT1 FOSL2 JUND OVOL3 SMIM2 SMIM2-IT1 SMIM2-AS1 lnc-SERP2-10 lnc-SERP2-9
GH13J044292 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -133.7 -133743 6 ZNF341 CEBPG FOS CEBPB USF1 FOSL1 JUND MITF TOE1 RXRA SERP2 SMIM2-IT1 SMIM2 LACC1 CCDC122 lnc-SERP2-15 piR-38352-139 lnc-SERP2-7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SMIM2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SMIM2

Genomic Locations for SMIM2 Gene

Genomic Locations for SMIM2 Gene
chr13:44,143,150-44,161,257
(GRCh38/hg38)
Size:
18,108 bases
Orientation:
Minus strand
chr13:44,717,679-44,735,393
(GRCh37/hg19)
Size:
17,715 bases
Orientation:
Minus strand

Genomic View for SMIM2 Gene

Genes around SMIM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM2 Gene

Proteins for SMIM2 Gene

  • Protein details for SMIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVW6-SMIM2_HUMAN
    Recommended name:
    Small integral membrane protein 2
    Protein Accession:
    Q9BVW6
    Secondary Accessions:
    • Q5SZS7

    Protein attributes for SMIM2 Gene

    Size:
    85 amino acids
    Molecular mass:
    9520 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM2 Gene

Post-translational modifications for SMIM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMIM2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM2 Gene

Domains & Families for SMIM2 Gene

Gene Families for SMIM2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SMIM2 Gene

ProtoNet:
genes like me logo Genes that share domains with SMIM2: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SMIM2 Gene

Function for SMIM2 Gene

Phenotypes From GWAS Catalog for SMIM2 Gene

Gene Ontology (GO) - Molecular Function for SMIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SMIM2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMIM2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMIM2 Gene

Localization for SMIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMIM2 gene
Compartment Confidence
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SMIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM2: view

Pathways & Interactions for SMIM2 Gene

PathCards logo

SuperPathways for SMIM2 Gene

No Data Available

Interacting Proteins for SMIM2 Gene

Selected Interacting proteins: Q9BVW6-SMIM2_HUMAN for SMIM2 Gene via UniProtKB IID

;

Gene Ontology (GO) - Biological Process for SMIM2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM2 Gene

Drugs & Compounds for SMIM2 Gene

No Compound Related Data Available

Transcripts for SMIM2 Gene

mRNA/cDNA for SMIM2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMIM2

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM2 Gene

No ASD Table

Relevant External Links for SMIM2 Gene

GeneLoc Exon Structure for
SMIM2

Expression for SMIM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SMIM2 Gene

mRNA differential expression in normal tissues according to GTEx for SMIM2 Gene

This gene is overexpressed in Testis (x21.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SMIM2

SOURCE GeneReport for Unigene cluster for SMIM2 Gene:

Hs.534877
genes like me logo Genes that share expression patterns with SMIM2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM2 Gene

Orthologs for SMIM2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMIM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMIM2 31
  • 100 (a)
OneToOne
LOC741476 30
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia SMIM2 30
  • 80 (n)
Species where no ortholog for SMIM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM2 Gene

ENSEMBL:
Gene Tree for SMIM2 (if available)
TreeFam:
Gene Tree for SMIM2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SMIM2: view image

Paralogs for SMIM2 Gene

No data available for Paralogs for SMIM2 Gene

Variants for SMIM2 Gene

Additional dbSNP identifiers (rs#s) for SMIM2 Gene

Structural Variations from Database of Genomic Variants (DGV) for SMIM2 Gene

Variant ID Type Subtype PubMed ID
nsv1048346 CNV gain 25217958

Variation tolerance for SMIM2 Gene

Gene Damage Index Score: 0.45; 9.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMIM2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SMIM2 Gene

Disorders for SMIM2 Gene

Additional Disease Information for SMIM2

No disorders were found for SMIM2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM2 Gene

Publications for SMIM2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 4 54

Products for SMIM2 Gene

Sources for SMIM2 Gene