Aliases for SMIM18 Gene

Aliases for SMIM18 Gene

  • Small Integral Membrane Protein 18 2 3 4 5

External Ids for SMIM18 Gene

Previous GeneCards Identifiers for SMIM18 Gene

  • GC08P030497

Summaries for SMIM18 Gene

GeneCards Summary for SMIM18 Gene

SMIM18 (Small Integral Membrane Protein 18) is a Protein Coding gene.

Additional gene information for SMIM18 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SMIM18 Gene

Genomics for SMIM18 Gene

GeneHancer (GH) Regulatory Elements for SMIM18 Gene

Promoters and enhancers for SMIM18 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J030638 Enhancer 0.6 Ensembl 507.9 -0.2 -179 5.2 EP300 ZSCAN5C GATA3 CEBPG SCRT1 PRDM6 ATF4 CEBPB ZBTB33 ATF3 SMIM18 GTF2E2 GSR hsa-miR-5096-117 RF00017-6937
GH08J030652 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 7.9 +17.5 17506 6.3 HNRNPK ZBTB40 ZSCAN5C SIN3A NRF1 USF1 POLR2G SP1 PHF8 ZFX GTF2E2 WRN SMIM18 PPP2CB RF00020-025 RNU5A-3P RF00017-6937
GH08J030616 Enhancer 0.9 ENCODE 11.9 -21.6 -21584 1.2 EP300 FOXK2 NCOR1 GTF2E2 KDM6A SKI TEAD1 FOXA2 KMT2B NR2F2 SMIM18 ENSG00000253112 RNU5A-3P lnc-GSR-3 hsa-miR-5096-117 GTF2E2 RF00017-6937
GH08J030561 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 7 -73.0 -72953 8.9 POLR2G POLR2A NR2F2 FOS RBM22 ESR1 CTCF RAD21 RXRA SMARCA4 RBPMS ENSG00000253112 RBPMS-AS1 SMIM18 GTF2E2 piR-46744 lnc-GTF2E2-2 RF00017-6937 lnc-SMIM18-2
GH08J030644 Enhancer 1 Ensembl ENCODE 7.7 +10.0 10020 8.4 USF1 FOS POLR2A NFYB ZNF341 RBM25 FOXA2 SP2 MAFF USF2 SMIM18 PPP2CB GTF2E2 RF00020-025 RNU5A-3P RF00017-6937
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SMIM18 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SMIM18

Genomic Locations for SMIM18 Gene

Genomic Locations for SMIM18 Gene
chr8:30,638,580-30,646,064
(GRCh38/hg38)
Size:
7,485 bases
Orientation:
Plus strand
chr8:30,496,117-30,503,581
(GRCh37/hg19)
Size:
7,465 bases
Orientation:
Plus strand

Genomic View for SMIM18 Gene

Genes around SMIM18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMIM18 Gene

Proteins for SMIM18 Gene

  • Protein details for SMIM18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DKX4-SIM18_HUMAN
    Recommended name:
    Small integral membrane protein 18
    Protein Accession:
    P0DKX4

    Protein attributes for SMIM18 Gene

    Size:
    95 amino acids
    Molecular mass:
    11088 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM18 Gene

Post-translational modifications for SMIM18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMIM18 Gene

No data available for DME Specific Peptides for SMIM18 Gene

Domains & Families for SMIM18 Gene

Gene Families for SMIM18 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SMIM18 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SMIM18: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SMIM18 Gene

Function for SMIM18 Gene

Phenotypes From GWAS Catalog for SMIM18 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMIM18

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMIM18 Gene

Localization for SMIM18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMIM18 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SMIM18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SMIM18: view

No data available for Subcellular locations from COMPARTMENTS for SMIM18 Gene

Pathways & Interactions for SMIM18 Gene

PathCards logo

SuperPathways for SMIM18 Gene

No Data Available

Interacting Proteins for SMIM18 Gene

;

Gene Ontology (GO) - Biological Process for SMIM18 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM18 Gene

Drugs & Compounds for SMIM18 Gene

No Compound Related Data Available

Transcripts for SMIM18 Gene

mRNA/cDNA for SMIM18 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMIM18

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM18 Gene

No ASD Table

Relevant External Links for SMIM18 Gene

GeneLoc Exon Structure for
SMIM18

Expression for SMIM18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SMIM18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMIM18 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.5), Brain - Cerebellar Hemisphere (x5.3), Brain - Cerebellum (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SMIM18

SOURCE GeneReport for Unigene cluster for SMIM18 Gene:

Hs.659493

Evidence on tissue expression from TISSUES for SMIM18 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with SMIM18: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM18 Gene

Orthologs for SMIM18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMIM18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMIM18 31
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SMIM18 30
  • 94.39 (n)
cow
(Bos Taurus)
Mammalia SMIM18 30
  • 93.68 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909793 30
  • 90.18 (n)
mouse
(Mus musculus)
Mammalia Smim18 17 31 30
  • 87.81 (n)
chicken
(Gallus gallus)
Aves SMIM18 30
  • 79.79 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia smim18 30
  • 69.82 (n)
Species where no ortholog for SMIM18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM18 Gene

ENSEMBL:
Gene Tree for SMIM18 (if available)
TreeFam:
Gene Tree for SMIM18 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SMIM18: view image

Paralogs for SMIM18 Gene

No data available for Paralogs for SMIM18 Gene

Variants for SMIM18 Gene

Additional dbSNP identifiers (rs#s) for SMIM18 Gene

Structural Variations from Database of Genomic Variants (DGV) for SMIM18 Gene

Variant ID Type Subtype PubMed ID
nsv526509 CNV gain 19592680

Variation tolerance for SMIM18 Gene

Gene Damage Index Score: 0.90; 18.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMIM18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SMIM18 Gene

Disorders for SMIM18 Gene

Additional Disease Information for SMIM18

No disorders were found for SMIM18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM18 Gene

Publications for SMIM18 Gene

  1. Discovery of 342 putative new genes from the analysis of 5'-end-sequenced full-length-enriched cDNA human transcripts. (PMID: 15885500) Dalla E … Schneider C (Genomics 2005) 3 4 54
  2. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli ET … Goldstein DB (European journal of human genetics : EJHG 2010) 3 54
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 54
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 54

Products for SMIM18 Gene

Sources for SMIM18 Gene