SMIM10L1 Gene (Protein Coding)

Small Integral Membrane Protein 10 Like 1

GC12P011171
GIFtS:
19

Aliases for SMIM10L1 Gene

Aliases for SMIM10L1 Gene

  • Small Integral Membrane Protein 10 Like 1 2 3 5
  • Small Integral Membrane Protein 10-Like Protein 1 3 3 4
  • Chromosome X Open Reading Frame 69-Like 3

External Ids for SMIM10L1 Gene

Summaries for SMIM10L1 Gene

GeneCards Summary for SMIM10L1 Gene

SMIM10L1 (Small Integral Membrane Protein 10 Like 1) is a Protein Coding gene. An important paralog of this gene is SMIM10L2A.

Additional gene information for SMIM10L1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SMIM10L1 Gene

Genomics for SMIM10L1 Gene

GeneHancer (GH) Regulatory Elements for SMIM10L1 Gene

Promoters and enhancers for SMIM10L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J011169 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 750.6 +0.3 320 4.2 ZNF785 SIN3A SP1 ZBTB6 RBPJ POLR2A HCFC1 MIXL1 ZNF133 MYC PRR4 TAS2R14 ENSG00000275778 ENSG00000256712 PRH1 PRH1-PRR4 SMIM10L1 LINC01252 TAS2R64P KLRA1P
GH12J011164 Enhancer 0.2 Ensembl 0.4 -6.8 -6780 1.2 TAS2R64P TAS2R15P lnc-TAS2R30-1-002 ENSG00000275778 SMIM10L1 TAS2R14 PRH1 PRH1-PRR4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SMIM10L1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SMIM10L1 Gene

Genomic Locations for SMIM10L1 Gene
chr12:11,171,181-11,176,020
(GRCh38/hg38)
Size:
4,840 bases
Orientation:
Plus strand
chr12:11,323,780-11,325,723
(GRCh37/hg19)
Size:
1,944 bases
Orientation:
Plus strand

Genomic View for SMIM10L1 Gene

Genes around SMIM10L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMIM10L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMIM10L1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SMIM10L1 Gene

Proteins for SMIM10L1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SMIM10L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DMW3-SIML1_HUMAN
    Recommended name:
    Small integral membrane protein 10-like protein 1
    Protein Accession:
    P0DMW3
    Secondary Accessions:
    • A0A0G2JPJ8

    Protein attributes for SMIM10L1 Gene

    Size:
    68 amino acids
    Molecular mass:
    7391 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMIM10L1 Gene

Post-translational modifications for SMIM10L1 Gene

No Post-translational modifications

Other Protein References for SMIM10L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMIM10L1 Gene

Domains & Families for SMIM10L1 Gene

Gene Families for SMIM10L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SMIM10L1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with SMIM10L1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SMIM10L1 Gene

Function for SMIM10L1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMIM10L1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMIM10L1 Gene

Localization for SMIM10L1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for SMIM10L1 Gene

Pathways & Interactions for SMIM10L1 Gene

PathCards logo

SuperPathways for SMIM10L1 Gene

No Data Available

Interacting Proteins for SMIM10L1 Gene

Gene Ontology (GO) - Biological Process for SMIM10L1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SMIM10L1 Gene

Drugs & Compounds for SMIM10L1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for SMIM10L1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for SMIM10L1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMIM10L1

Alternative Splicing Database (ASD) splice patterns (SP) for SMIM10L1 Gene

No ASD Table

Relevant External Links for SMIM10L1 Gene

GeneLoc Exon Structure for
SMIM10L1
ECgene alternative splicing isoforms for
SMIM10L1

Expression for SMIM10L1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMIM10L1 Gene

mRNA expression in normal human tissues for SMIM10L1 Gene
mRNA expression by GTEx for SMIM10L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SMIM10L1 Gene:

SMIM10L1
genes like me logo Genes that share expression patterns with SMIM10L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMIM10L1 Gene

Orthologs for SMIM10L1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMIM10L1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia LOC102152117 32
  • 88.73 (n)
rat
(Rattus norvegicus)
 Mammalia LOC100360120 32
  • 88.69 (n)
mouse
(Mus musculus)
 Mammalia 2700089E24Rik 32
  • 85.12 (n)
Smim10l1 17
Species where no ortholog for SMIM10L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMIM10L1 Gene

ENSEMBL:
Gene Tree for SMIM10L1 (if available)
TreeFam:
Gene Tree for SMIM10L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SMIM10L1: view image

Paralogs for SMIM10L1 Gene

Paralogs for SMIM10L1 Gene

Pseudogenes.org Pseudogenes for SMIM10L1 Gene

genes like me logo Genes that share paralogs with SMIM10L1: view

Variants for SMIM10L1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for SMIM10L1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000099420 -- 11,173,496(+) G/T 3_prime_UTR_variant
rs1000422884 -- 11,170,853(+) A/G upstream_transcript_variant
rs1000874378 -- 11,169,820(+) G/A upstream_transcript_variant
rs1001132920 -- 11,174,182(+) ACAAAACAA/ACAA 3_prime_UTR_variant
rs1001867940 -- 11,175,294(+) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for SMIM10L1 Gene

Variant ID Type Subtype PubMed ID
dgv1378n100 CNV loss 25217958
esv2759879 CNV loss 17122850
nsv1038277 CNV loss 25217958
nsv1050050 CNV loss 25217958
nsv428272 CNV gain+loss 18775914

Additional Variant Information for SMIM10L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMIM10L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SMIM10L1 Gene

Disorders for SMIM10L1 Gene

Additional Disease Information for SMIM10L1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SMIM10L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMIM10L1 Gene

Publications for SMIM10L1 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 56

ExternalLinks

View latest publications for SMIM10L1 gene in Mastermind

Products for SMIM10L1 Gene

Sources for SMIM10L1 Gene