Aliases for SMG8 Gene
External Ids for SMG8 Gene
Previous HGNC Symbols for SMG8 Gene
Previous GeneCards Identifiers for SMG8 Gene
GeneCards Summary for SMG8 Gene
SMG8 (SMG8 Nonsense Mediated MRNA Decay Factor) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Gene Expression. An important paralog of this gene is ENSG00000265303.
UniProtKB/Swiss-Prot Summary for SMG8 Gene
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.