Aliases for SMG7 Gene
External Ids for SMG7 Gene
Previous HGNC Symbols for SMG7 Gene
Previous GeneCards Identifiers for SMG7 Gene
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
GeneCards Summary for SMG7 Gene
SMG7 (SMG7 Nonsense Mediated MRNA Decay Factor) is a Protein Coding gene. Diseases associated with SMG7 include Progressive Familial Heart Block, Type Ii and Pancreatic Adenosquamous Carcinoma. Among its related pathways are Gene Expression and mRNA surveillance pathway. Gene Ontology (GO) annotations related to this gene include protein phosphatase 2A binding. An important paralog of this gene is SMG5.
UniProtKB/Swiss-Prot Summary for SMG7 Gene
Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.