Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organi... See more...

Aliases for SMCP Gene

Aliases for SMCP Gene

  • Sperm Mitochondria Associated Cysteine Rich Protein 2 3 5
  • Sperm Mitochondrial-Associated Cysteine-Rich Protein 3 4
  • MCSP 3 4
  • MCS 3 4
  • Sperm Mitochondria-Associated Cysteine-Rich Protein 2
  • Mitochondrial Capsule Selenoprotein 2
  • Testicular Tissue Protein Li 119 3
  • Testicular Tissue Protein Li 161 3
  • HSMCSGEN1 3
  • SMCP 5

External Ids for SMCP Gene

Previous HGNC Symbols for SMCP Gene

  • MCSP

Previous GeneCards Identifiers for SMCP Gene

  • GC01P149664
  • GC01P151117
  • GC01P152850
  • GC01P124213

Summaries for SMCP Gene

Entrez Gene Summary for SMCP Gene

  • Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath. [provided by RefSeq, Jul 2008]

GeneCards Summary for SMCP Gene

SMCP (Sperm Mitochondria Associated Cysteine Rich Protein) is a Protein Coding gene. Diseases associated with SMCP include Male Infertility and Infertility.

UniProtKB/Swiss-Prot Summary for SMCP Gene

  • Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).

Gene Wiki entry for SMCP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SMCP Gene

Genomics for SMCP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SMCP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J152870 Promoter 0.8 EPDnew 250.4 -8.3 -8281 0.1 ZNF654 CTCF REST DEK TRIM22 RAD21 SMC3 CBFB FOXK2 ZNF143 HSALNG0007247-001 LOC105371444 SMCP LOC105371445 ENSG00000285946
GH01J152878 Promoter 0.6 EPDnew 250.7 0.0 -19 0.1 CTCF SMC3 RAD21 SMCP LOC105371445 ENSG00000285946
GH01J153231 Enhancer 0.8 Ensembl ENCODE 10.5 +352.9 352884 6.4 ZNF654 CTCF NR2C1 HNF4A NR2F1 NFIB RAD21 MNT FOS ESRRA PRR9 LORICRIN LELP1 SMCP SPRR2G HSALNG0007277 HSALNG0007278 RPLP0P4 HSALNG0007276
GH01J152904 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 0.3 +28.4 28379 3.8 BCLAF1 ATF2 IRF4 EBF1 ZBTB48 PKNOX1 BATF ZFP37 JUND IKZF1 IVL JA662202 RF00994-056 SMCP
GH01J152879 Enhancer 0.5 ENCODE 0.7 +2.2 2201 1.6 YY1 FOXA2 RXRA JUND HNF4A EED TCF12 CEBPB SP1 SMCP RF00994-056 IVL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SMCP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SMCP

Top Transcription factor binding sites by QIAGEN in the SMCP gene promoter:
  • AML1a
  • AP-1
  • AREB6
  • c-Fos
  • c-Jun
  • c-Myc
  • E47
  • SRF
  • SRF (504 AA)
  • Tal-1

Genomic Locations for SMCP Gene

Latest Assembly
chr1:152,878,322-152,885,047
(GRCh38/hg38)
Size:
6,726 bases
Orientation:
Plus strand

Previous Assembly
chr1:152,850,798-152,857,523
(GRCh37/hg19 by Entrez Gene)
Size:
6,726 bases
Orientation:
Plus strand

chr1:152,850,793-152,857,523
(GRCh37/hg19 by Ensembl)
Size:
6,731 bases
Orientation:
Plus strand

Genomic View for SMCP Gene

Genes around SMCP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMCP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMCP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMCP Gene

Proteins for SMCP Gene

  • Protein details for SMCP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49901-MCSP_HUMAN
    Recommended name:
    Sperm mitochondrial-associated cysteine-rich protein
    Protein Accession:
    P49901
    Secondary Accessions:
    • Q96A42

    Protein attributes for SMCP Gene

    Size:
    116 amino acids
    Molecular mass:
    12767 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMCP Gene

Post-translational modifications for SMCP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMCP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SMCP Gene

Domains & Families for SMCP Gene

Gene Families for SMCP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SMCP Gene

InterPro:

Suggested Antigen Peptide Sequences for SMCP Gene

GenScript: Design optimal peptide antigens:
  • Sperm mitochondrial-associated cysteine-rich protein (MCSP_HUMAN)
  • cDNA, FLJ92296, Homo sapiens mitochondrial capsule selenoprotein (MCSP), nucleargene encoding mitochondrial protein, mRNA (Q5T7P5_HUMAN)
genes like me logo Genes that share domains with SMCP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SMCP Gene

Function for SMCP Gene

Molecular function for SMCP Gene

UniProtKB/Swiss-Prot Function:
Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity).

Phenotypes From GWAS Catalog for SMCP Gene

Gene Ontology (GO) - Molecular Function for SMCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with SMCP: view
genes like me logo Genes that share phenotypes with SMCP: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMCP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SMCP Gene

Localization for SMCP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMCP Gene

Cytoplasm. Mitochondrion membrane. Peripheral membrane protein. Cytoplasmic side. Note=Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMCP gene
Compartment Confidence
mitochondrion 4
extracellular 3
cytosol 3
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SMCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion ISS --
GO:0016020 membrane IEA --
GO:0031966 mitochondrial membrane IEA --
genes like me logo Genes that share ontologies with SMCP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SMCP Gene

Pathways & Interactions for SMCP Gene

PathCards logo

SuperPathways for SMCP Gene

No Data Available

Gene Ontology (GO) - Biological Process for SMCP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization IEA --
GO:0007341 penetration of zona pellucida ISS --
GO:0030317 flagellated sperm motility ISS --
genes like me logo Genes that share ontologies with SMCP: view

No data available for Pathways by source and SIGNOR curated interactions for SMCP Gene

Drugs & Compounds for SMCP Gene

(2) Drugs for SMCP Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SMCP: view

Transcripts for SMCP Gene

mRNA/cDNA for SMCP Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMCP

Alternative Splicing Database (ASD) splice patterns (SP) for SMCP Gene

No ASD Table

Relevant External Links for SMCP Gene

GeneLoc Exon Structure for
SMCP

Expression for SMCP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SMCP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMCP Gene

This gene is overexpressed in Testis (x52.4).

Protein differential expression in normal tissues from HIPED for SMCP Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SMCP Gene



Protein tissue co-expression partners for SMCP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SMCP

SOURCE GeneReport for Unigene cluster for SMCP Gene:

Hs.111850

mRNA Expression by UniProt/SwissProt for SMCP Gene:

P49901-MCSP_HUMAN
Tissue specificity: Testis. Is selectively expressed in the spermatids of seminiferous tubules.
genes like me logo Genes that share expression patterns with SMCP: view

Primer products for research

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMCP Gene

Orthologs for SMCP Gene

This gene was present in the common ancestor of mammals.

Orthologs for SMCP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SMCP 29 30
  • 97.99 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia SMCP 30
  • 47 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia SMCP 30
  • 42 (a)
OneToOne
Species where no ortholog for SMCP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for SMCP Gene

ENSEMBL:
Gene Tree for SMCP (if available)
TreeFam:
Gene Tree for SMCP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SMCP: view image
Alliance of Genome Resources:
Additional Orthologs for SMCP

Paralogs for SMCP Gene

No data available for Paralogs for SMCP Gene

Variants for SMCP Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SMCP Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SMCP Gene

Variant ID Type Subtype PubMed ID
dgv432n100 CNV gain 25217958
esv2758970 CNV gain+loss 17122850
esv2761937 CNV gain 21179565
esv3587570 CNV gain 21293372
esv7910 CNV gain 19470904
nsv1008447 CNV gain 25217958
nsv1129135 CNV insertion 24896259
nsv547899 CNV gain 21841781
nsv831592 CNV gain 17160897

Variation tolerance for SMCP Gene

Residual Variation Intolerance Score: 73.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.32; 7.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMCP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMCP
Leiden Open Variation Database (LOVD)
SMCP

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SMCP Gene

Disorders for SMCP Gene

MalaCards: The human disease database

(2) MalaCards diseases for SMCP Gene - From: COP and GCD

Disorder Aliases PubMed IDs
male infertility
  • infertility male
infertility
- elite association - COSMIC cancer census association via MalaCards
Search SMCP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for SMCP

genes like me logo Genes that share disorders with SMCP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SMCP Gene

Publications for SMCP Gene

  1. Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP). (PMID: 8833144) Aho H … Adham IM (Genomics 1996) 2 3 4 22
  2. Comparative genomics of the sperm mitochondria-associated cysteine-rich protein gene. (PMID: 16325371) Hawthorne SK … Kleene KC (Genomics 2006) 3 22
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3

Products for SMCP Gene

Sources for SMCP Gene