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Aliases for SMCO2 Gene
Aliases for SMCO2 Gene
External Ids for SMCO2 Gene
- HGNC: 34448
- Entrez Gene: 341346
- Ensembl: ENSG00000165935
- UniProtKB: A6NFE2
Previous HGNC Symbols for SMCO2 Gene
- C12orf70
Previous GeneCards Identifiers for SMCO2 Gene
- GC12P027620
- GC12P027466
Summaries for SMCO2 Gene
GeneCards Summary for SMCO2 Gene
SMCO2 (Single-Pass Membrane Protein With Coiled-Coil Domains 2) is a Protein Coding gene. Diseases associated with SMCO2 include Gender Identity Disorder. An important paralog of this gene is TMCO5A.
Additional gene information for SMCO2 Gene
- HGNC(34448)
- Entrez Gene(341346)
- Ensembl(ENSG00000165935)
- UniProtKB(A6NFE2)
- Open Targets Platform(ENSG00000165935)
- Monarch Initiative
- Search for SMCO2 at DataMed
- Search for SMCO2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SMCO2 Gene
Genomics for SMCO2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for SMCO2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around SMCO2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SMCO2
Genomic Locations for SMCO2 Gene
Genomic Locations for SMCO2 Gene
- chr12:27,446,482-27,506,911
- (GRCh38/hg38)
- Size:
- 60,430 bases
- Orientation:
- Plus strand
- chr12:27,619,743-27,655,118
- (GRCh37/hg19)
- Size:
- 35,376 bases
- Orientation:
- Plus strand
Genomic View for SMCO2 Gene
Genes around SMCO2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p11.23 by HGNC
- 12p11.23 by Entrez Gene
- 12p11.23 by Ensembl
SMCO2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SMCO2 Gene
Proteins for SMCO2 Gene
-
Protein details for SMCO2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A6NFE2-SMCO2_HUMAN
- Recommended name:
- Single-pass membrane and coiled-coil domain-containing protein 2
- Protein Accession:
- A6NFE2
Protein attributes for SMCO2 Gene
- Size:
- 343 amino acids
- Molecular mass:
- 39487 Da
- Quaternary structure:
- No Data Available
Protein Expression for SMCO2 Gene
Post-translational modifications for SMCO2 Gene
Other Protein References for SMCO2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SMCO2
- Novus Biologicals Antibodies for SMCO2
- Invitrogen Antibodies for SMCO2 (AFLGC-SMCO2)
- antibodies-online: Show 3 available SMCO2 Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for SMCO2
- Search Origene for MassSpec and Protein Over-expression Lysates for SMCO2
- Origene Custom Protein Services for SMCO2
- Novus Biologicals proteins for SMCO2
No data available for DME Specific Peptides for SMCO2 Gene
Domains & Families for SMCO2 Gene
Gene Families for SMCO2 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for SMCO2 Gene
Function for SMCO2 Gene
Phenotypes From GWAS Catalog for SMCO2 Gene
Phenotypes for SMCO2 Gene
- MGI mutant phenotypes for SMCO2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for SMCO2:
Animal Models for SMCO2 Gene
- MGI Knock Outs for SMCO2:
-
- Smco2 Smco2<tm1b(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SMCO2 - Select products 50% OFF >
- * SMCO2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SMCO2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SMCO2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SMCO2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SMCO2
- Browse OriGene Inhibitory RNA Products For SMCO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMCO2
Clone Products
- Applied Biological Materials (abm): Clones for SMCO2 - Select products 50% OFF >
- * SMCO2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SMCO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SMCO2
Cell Line Products
-
Horizon Cell Lines for SMCO2
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SMCO2 Gene
Localization for SMCO2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SMCO2 Gene
- Membrane. Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SMCO2 Gene
Transcripts for SMCO2 Gene
mRNA/cDNA for SMCO2 Gene
- 1 REFSEQ mRNAs :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000298876 1122 nts (view in UCSC)
- ENST00000416383 1272 nts (view in UCSC)
- ENST00000535986 1096 nts (view in UCSC)
- ENST00000538647 287 nts (view in UCSC)
- ENST00000541168 922 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for SMCO2 - Select products 50% OFF >
- * SMCO2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for SMCO2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SMCO2
-
Santa Cruz Biotechnology (SCBT) CRISPR for SMCO2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SMCO2
- Browse OriGene Inhibitory RNA Products For SMCO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMCO2
Clone Products
- Applied Biological Materials (abm): Clones for SMCO2 - Select products 50% OFF >
- * SMCO2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for SMCO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SMCO2
Relevant External Links for SMCO2 Gene
- GeneLoc Exon Structure for
- SMCO2
Expression for SMCO2 Gene
mRNA differential expression in normal tissues according to GTEx for SMCO2 Gene
This gene is overexpressed in Esophagus - Mucosa (x4.8) and Testis (x4.5).
This gene is overexpressed in Plasma (64.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SMCO2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SMCO2
SOURCE GeneReport for Unigene cluster for SMCO2 Gene:
Hs.282121Primer Products
-
OriGene qPCR primer pairs for SMCO2
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMCO2 Gene
Orthologs for SMCO2 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | SMCO2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | C5H12orf70 30 |
|
||
| SMCO2 31 |
|
OneToOne | |||
| Dog (Canis familiaris) |
Mammalia | SMCO2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Smco2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | LOC100361371 30 |
|
- Species where no ortholog for SMCO2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for SMCO2 Gene
- ENSEMBL:
- Gene Tree for SMCO2 (if available)
- TreeFam:
- Gene Tree for SMCO2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for SMCO2: view image
Paralogs for SMCO2 Gene
Variants for SMCO2 Gene
Gene Damage Index Score:
4.19;
61.91% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SMCO2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SMCO2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SMCO2 Gene
Disorders for SMCO2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gender identity disorder |
|
|
Search SMCO2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for SMCO2
No data available for UniProtKB/Swiss-Prot and Genatlas for SMCO2 Gene
Publications for SMCO2 Gene
- The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4
ExternalLinks
Products for SMCO2 Gene
- Custom Antibody ServicesOriGene Antibodies for SMCO2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SMCO2
- Search Origene for MassSpec and Protein Over-expression Lysates for SMCO2
- Origene Custom Protein Services for SMCO2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for SMCO2
- Browse OriGene Inhibitory RNA Products For SMCO2
- OriGene qPCR primer pairs for SMCO2
- OriGene CRISPR knockouts for SMCO2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For SMCO2
- Sino Biological Human cDNA Clone for SMCO2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for SMCO2
- Novus Biologicals proteins for SMCO2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for SMCO2 (AFLGC-SMCO2)
- VectorBuilder Custom and pre-made DNA vectors for SMCO2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for SMCO2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for SMCO2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for SMCO2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for SMCO2
- antibodies-online: Show 3 available SMCO2 Antibodies ranked by validation data
- antibodies-online: Search results for available SMCO2 related products ranked by validation data
- antibodies-online: Search results for available SMCO2 related products ranked by validation data
- Horizon Cell Lines for SMCO2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for SMCO2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for SMCO2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for SMCO2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMCO2
Sources for SMCO2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB