Aliases for SMC5 Gene
External Ids for SMC5 Gene
Previous HGNC Symbols for SMC5 Gene
Previous GeneCards Identifiers for SMC5 Gene
GeneCards Summary for SMC5 Gene
SMC5 (Structural Maintenance Of Chromosomes 5) is a Protein Coding gene. Diseases associated with SMC5 include Chromosome 5P13 Duplication Syndrome and Cornelia De Lange Syndrome. Among its related pathways are Metabolism of proteins and SUMOylation. An important paralog of this gene is SMC6.
UniProtKB/Swiss-Prot Summary for SMC5 Gene
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).