Aliases for SMC1B Gene
External Ids for SMC1B Gene
Previous HGNC Symbols for SMC1B Gene
Previous GeneCards Identifiers for SMC1B Gene
SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001 [PubMed 11564881]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SMC1B Gene
SMC1B (Structural Maintenance Of Chromosomes 1B) is a Protein Coding gene. Diseases associated with SMC1B include Corneal Dystrophy, Subepithelial Mucinous and 46 Xx Gonadal Dysgenesis. Among its related pathways are Cell Cycle, Mitotic and Meiosis. An important paralog of this gene is SMC1A.
UniProtKB/Swiss-Prot Summary for SMC1B Gene
Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).