Aliases for SMARCD2 Gene
- SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily D, Member 2 2 3 5
- SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily D Member 2 3 4
- Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 60B 2 3
- 60 KDa BRG-1/Brm-Associated Factor Subunit B 3 4
- Chromatin Remodeling Complex BAF60B Subunit 2 3
- SWI/SNF Complex 60 KDa Subunit B 2 3
External Ids for SMARCD2 Gene
Previous GeneCards Identifiers for SMARCD2 Gene
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for SMARCD2 Gene
SMARCD2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily D, Member 2) is a Protein Coding gene. Diseases associated with SMARCD2 include Specific Granule Deficiency 2 and Autosomal Recessive Severe Congenital Neutropenia. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and RNA polymerase II distal enhancer sequence-specific DNA binding. An important paralog of this gene is SMARCD3.
UniProtKB/Swiss-Prot Summary for SMARCD2 Gene
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:22952240, PubMed:26601204). Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation (PubMed:28369036).