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Aliases for SMAGP Gene

Aliases for SMAGP Gene

  • Small Cell Adhesion Glycoprotein 2 3 5
  • Small Trans-Membrane And Glycosylated Protein 2 3
  • Small Transmembrane And Glycosylated Protein 3 4
  • Small Cell Transmembrane And Glycosylated Protein 3
  • HSMAGP 3

External Ids for SMAGP Gene

Previous GeneCards Identifiers for SMAGP Gene

  • GC12M049926
  • GC12M051639
  • GC12M048672

Summaries for SMAGP Gene

GeneCards Summary for SMAGP Gene

SMAGP (Small Cell Adhesion Glycoprotein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SMAGP Gene

  • May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.

Additional gene information for SMAGP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMAGP Gene

Genomics for SMAGP Gene

GeneHancer (GH) Regulatory Elements for SMAGP Gene

Promoters and enhancers for SMAGP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I051268 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 557.8 +0.5 538 3.1 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 GLIS2 ARID2 FOS SMAGP LOC102723983 POU6F1 BIN2 CELA1 DAZAP2 CSRNP2
GH12I051317 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.4 -52.2 -52197 10.3 HDGF PKNOX1 ARNT POLR2B ZNF766 ZNF143 REST ZNF592 MEF2D SMARCA4 BIN2 LOC105369767 CELA1 HNRNPA3P10 POU6F1 DAZAP2 SMAGP SLC11A2 PHBP19 GALNT6
GH12I051262 Enhancer 1.2 Ensembl ENCODE dbSUPER 5.6 +7.8 7756 1.1 HDAC1 MEIS2 CTCF ESRRA SIN3A RAD21 GTF3C2 FOSL1 ZNF121 GATA3 BIN2 DAZAP2 GALNT6 SLC4A8 SMAGP LOC102723983
GH12I051280 Enhancer 0.5 dbSUPER 7.5 -10.7 -10718 1.9 ATF4 JUND JUN SCRT2 CEBPB EP300 ATF2 BIN2 DAZAP2 CELA1 SLC4A8 GALNT6 CSRNP2 RNU6-1273P LETMD1 SLC11A2 SMAGP
GH12I051274 Enhancer 0.4 dbSUPER 7.1 -4.4 -4403 0.9 KLF1 ZNF341 POU6F1 BIN2 CELA1 DAZAP2 CSRNP2 SMAGP LOC105369767
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SMAGP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SMAGP gene promoter:

Genomic Locations for SMAGP Gene

Genomic Locations for SMAGP Gene
chr12:51,244,558-51,270,890
(GRCh38/hg38)
Size:
26,333 bases
Orientation:
Minus strand
chr12:51,638,342-51,664,674
(GRCh37/hg19)

Genomic View for SMAGP Gene

Genes around SMAGP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMAGP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMAGP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMAGP Gene

Proteins for SMAGP Gene

  • Protein details for SMAGP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VAQ4-SMAGP_HUMAN
    Recommended name:
    Small cell adhesion glycoprotein
    Protein Accession:
    Q0VAQ4
    Secondary Accessions:
    • A6NIL5

    Protein attributes for SMAGP Gene

    Size:
    97 amino acids
    Molecular mass:
    10679 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMAGP Gene

Post-translational modifications for SMAGP Gene

  • O-glycosylated. The O-glycan is modified with sialic acid residues.
  • Glycosylation at isoforms=2, posLast=33, isoforms=6, isoforms=7, isoforms=9, isoforms=16, isoforms=17, and posLast=2323
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SMAGP Gene

Domains & Families for SMAGP Gene

Gene Families for SMAGP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SMAGP Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SMAGP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q0VAQ4

UniProtKB/Swiss-Prot:

SMAGP_HUMAN :
  • Belongs to the SMAGP family.
Family:
  • Belongs to the SMAGP family.
genes like me logo Genes that share domains with SMAGP: view

Function for SMAGP Gene

Molecular function for SMAGP Gene

UniProtKB/Swiss-Prot Function:
May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.

Gene Ontology (GO) - Molecular Function for SMAGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IBA --
GO:0050839 cell adhesion molecule binding IBA --
genes like me logo Genes that share ontologies with SMAGP: view

Phenotypes for SMAGP Gene

GenomeRNAi human phenotypes for SMAGP:
genes like me logo Genes that share phenotypes with SMAGP: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMAGP Gene

Localization for SMAGP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMAGP Gene

Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle membrane; Single-pass type III membrane protein. Note=Predominantly on lateral parts of the membrane, at cell-cell epithelial junctions (PubMed:15021913). Detected on cytoplasmic membranes in undifferentiated tumors (PubMed:15986429). {ECO:0000269 PubMed:15021913, ECO:0000269 PubMed:15986429}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMAGP gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SMAGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0005887 integral component of plasma membrane IBA --
GO:0005913 cell-cell adherens junction IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SMAGP: view

Pathways & Interactions for SMAGP Gene

SuperPathways for SMAGP Gene

No Data Available

Interacting Proteins for SMAGP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369446%0d%0a9606.ENSP00000264335%0d%0a
Selected Interacting proteins: Q0VAQ4-SMAGP_HUMAN ENSP00000369446 for SMAGP Gene via IID STRING UniProtKB

Gene Ontology (GO) - Biological Process for SMAGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
GO:0008037 cell recognition IBA --
genes like me logo Genes that share ontologies with SMAGP: view

No data available for Pathways by source and SIGNOR curated interactions for SMAGP Gene

Drugs & Compounds for SMAGP Gene

No Compound Related Data Available

Transcripts for SMAGP Gene

Unigene Clusters for SMAGP Gene

Small cell adhesion glycoprotein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMAGP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -

Relevant External Links for SMAGP Gene

GeneLoc Exon Structure for
SMAGP
ECgene alternative splicing isoforms for
SMAGP

Expression for SMAGP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMAGP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMAGP Gene

This gene is overexpressed in Esophagus - Mucosa (x11.7), Colon - Transverse (x5.2), and Vagina (x5.1).

Protein differential expression in normal tissues from HIPED for SMAGP Gene

This gene is overexpressed in Placenta (56.1), Cerebral cortex (6.8), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SMAGP Gene



Protein tissue co-expression partners for SMAGP Gene

NURSA nuclear receptor signaling pathways regulating expression of SMAGP Gene:

SMAGP

SOURCE GeneReport for Unigene cluster for SMAGP Gene:

Hs.652389

mRNA Expression by UniProt/SwissProt for SMAGP Gene:

Q0VAQ4-SMAGP_HUMAN
Tissue specificity: Detected in breast, endometrium, colon and biliary tract. Detected in polarized epithelial structures characterized by cell-cell adhesion (at protein level).

Evidence on tissue expression from TISSUES for SMAGP Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with SMAGP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SMAGP Gene

Orthologs for SMAGP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMAGP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SMAGP 34 33
  • 99.66 (n)
OneToOne
dog
(Canis familiaris)
Mammalia SMAGP 34 33
  • 89.56 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SMAGP 34 33
  • 86.25 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Smagp 16 34 33
  • 86.11 (n)
rat
(Rattus norvegicus)
Mammalia Smagp 33
  • 85.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SMAGP 34
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SMAGP 34
  • 47 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18833 33
Species where no ortholog for SMAGP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMAGP Gene

ENSEMBL:
Gene Tree for SMAGP (if available)
TreeFam:
Gene Tree for SMAGP (if available)

Paralogs for SMAGP Gene

(2) SIMAP similar genes for SMAGP Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SMAGP: view

No data available for Paralogs for SMAGP Gene

Variants for SMAGP Gene

Sequence variations from dbSNP and Humsavar for SMAGP Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000154132 -- 51,250,750(-) T/A intron_variant
rs1000680074 -- 51,270,113(-) G/C 5_prime_UTR_variant, intron_variant
rs1000906103 -- 51,268,641(-) G/A intron_variant
rs1000976882 -- 51,256,645(-) A/G intron_variant
rs1001108702 -- 51,250,149(-) C/A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SMAGP Gene

Variant ID Type Subtype PubMed ID
esv3308888 CNV mobile element insertion 20981092
esv34039 CNV loss 18971310
nsv704 CNV insertion 18451855

Variation tolerance for SMAGP Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMAGP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMAGP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMAGP Gene

Disorders for SMAGP Gene

Additional Disease Information for SMAGP

No disorders were found for SMAGP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMAGP Gene

Publications for SMAGP Gene

  1. SMAGP, a new small trans-membrane glycoprotein altered in cancer. (PMID: 15021913) Tarbé NG … Weidle UH (Oncogene 2004) 2 3 4 58
  2. Overexpression of the small transmembrane and glycosylated protein SMAGP supports metastasis formation of a rat pancreatic adenocarcinoma line. (PMID: 15986429) Tarbé NG … Zöller M (International journal of cancer 2005) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58
  5. Rapid identification of 14-3-3-binding proteins by protein microarray analysis. (PMID: 16260042) Satoh J … Yamamura T (Journal of neuroscience methods 2006) 3 58

Products for SMAGP Gene

Sources for SMAGP Gene

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