Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SMAGP Gene

Aliases for SMAGP Gene

  • Small Cell Adhesion Glycoprotein 2 3 3 5
  • Small Trans-Membrane And Glycosylated Protein 2 3
  • Small Transmembrane And Glycosylated Protein 3 4
  • Small Cell Transmembrane And Glycosylated Protein 3
  • HSMAGP 3

External Ids for SMAGP Gene

Previous GeneCards Identifiers for SMAGP Gene

  • GC12M049926
  • GC12M051639
  • GC12M048672

Summaries for SMAGP Gene

GeneCards Summary for SMAGP Gene

SMAGP (Small Cell Adhesion Glycoprotein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SMAGP Gene

  • May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.

Additional gene information for SMAGP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SMAGP Gene

Genomics for SMAGP Gene

GeneHancer (GH) Regulatory Elements for SMAGP Gene

Promoters and enhancers for SMAGP Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J051268 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 657.8 +0.5 538 3.1 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 GLIS2 ARID2 ZFP91 SMAGP LOC102723983 TFCP2 POU6F1 BIN2 CELA1 DAZAP2 CSRNP2
GH12J050762 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.1 +506.1 506093 5.6 CLOCK FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 GLIS1 NBN NR2C1 ATF1 SMARCD1 HNRNPA3P10 BCDIN3D SLC11A2 TFCP2 SMAGP LIMA1 RNU6-1273P RNU6-769P
GH12J051969 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -701.7 -701703 5.2 PKNOX1 FOXA2 ARNT ZNF2 IRF4 YY1 ZNF766 E2F8 ZNF143 FOS NR4A1 HNRNPA3P10 GRASP ATG101 ACVR1B ACVRL1 ANKRD33 SMAGP GC12P051989
GH12J051262 Enhancer 1.2 Ensembl ENCODE dbSUPER 15.1 +7.8 7756 1.1 HDAC1 MEIS2 CTCF ESRRA SIN3A RAD21 GTF3C2 FOSL1 ZNF121 GATA3 HNRNPA3P10 BIN2 SMAGP ATG101 ATF1 DAZAP2 SLC4A8 GALNT6 LOC102723983
GH12J051317 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.4 -52.2 -52197 10.3 HDGF PKNOX1 ARNT POLR2B ZNF766 ZNF143 REST ZNF592 MEF2D SMARCA4 BIN2 LOC105369767 CELA1 HNRNPA3P10 POU6F1 DAZAP2 SMAGP SLC11A2 PHBP19 GALNT6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SMAGP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SMAGP gene promoter:
  • FOXF2
  • Evi-1
  • FOXL1
  • AP-1
  • Msx-1

Genomic Locations for SMAGP Gene

Genomic Locations for SMAGP Gene
26,333 bases
Minus strand
26,333 bases
Minus strand

Genomic View for SMAGP Gene

Genes around SMAGP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMAGP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMAGP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMAGP Gene

Proteins for SMAGP Gene

  • Protein details for SMAGP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small cell adhesion glycoprotein
    Protein Accession:
    Secondary Accessions:
    • A6NIL5

    Protein attributes for SMAGP Gene

    97 amino acids
    Molecular mass:
    10679 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SMAGP Gene

Post-translational modifications for SMAGP Gene

  • O-glycosylated. The O-glycan is modified with sialic acid residues.
  • Glycosylation at posLast=2323, posLast=1717, isoforms=16, isoforms=9, posLast=77, posLast=66, posLast=33, and isoforms=2
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SMAGP Gene

Domains & Families for SMAGP Gene

Gene Families for SMAGP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for SMAGP Gene


Suggested Antigen Peptide Sequences for SMAGP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SMAGP family.
  • Belongs to the SMAGP family.
genes like me logo Genes that share domains with SMAGP: view

Function for SMAGP Gene

Molecular function for SMAGP Gene

UniProtKB/Swiss-Prot Function:
May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation.

Gene Ontology (GO) - Molecular Function for SMAGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0042803 protein homodimerization activity IBA --
GO:0050839 cell adhesion molecule binding IBA --
genes like me logo Genes that share ontologies with SMAGP: view

Phenotypes for SMAGP Gene

genes like me logo Genes that share phenotypes with SMAGP: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SMAGP Gene

Localization for SMAGP Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMAGP Gene

Cell membrane; Single-pass type III membrane protein. Cytoplasmic vesicle membrane; Single-pass type III membrane protein. Note=Predominantly on lateral parts of the membrane, at cell-cell epithelial junctions (PubMed:15021913). Detected on cytoplasmic membranes in undifferentiated tumors (PubMed:15986429). {ECO:0000269 PubMed:15021913, ECO:0000269 PubMed:15986429}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMAGP gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SMAGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0005887 integral component of plasma membrane IBA --
GO:0005913 cell-cell adherens junction IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SMAGP: view

Pathways & Interactions for SMAGP Gene

SuperPathways for SMAGP Gene

No Data Available

Interacting Proteins for SMAGP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q0VAQ4-SMAGP_HUMAN ENSP00000369446 for SMAGP Gene via IID STRING UniProtKB

Gene Ontology (GO) - Biological Process for SMAGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
GO:0008037 cell recognition IBA --
genes like me logo Genes that share ontologies with SMAGP: view

No data available for Pathways by source and SIGNOR curated interactions for SMAGP Gene

Drugs & Compounds for SMAGP Gene

No Compound Related Data Available

Transcripts for SMAGP Gene

mRNA/cDNA for SMAGP Gene

Unigene Clusters for SMAGP Gene

Small cell adhesion glycoprotein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SMAGP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -

Relevant External Links for SMAGP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SMAGP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SMAGP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMAGP Gene

This gene is overexpressed in Esophagus - Mucosa (x11.7), Colon - Transverse (x5.2), and Vagina (x5.1).

Protein differential expression in normal tissues from HIPED for SMAGP Gene

This gene is overexpressed in Placenta (56.1), Cerebral cortex (6.8), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SMAGP Gene

Protein tissue co-expression partners for SMAGP Gene

NURSA nuclear receptor signaling pathways regulating expression of SMAGP Gene:


SOURCE GeneReport for Unigene cluster for SMAGP Gene:


mRNA Expression by UniProt/SwissProt for SMAGP Gene:

Tissue specificity: Detected in breast, endometrium, colon and biliary tract. Detected in polarized epithelial structures characterized by cell-cell adhesion (at protein level).

Evidence on tissue expression from TISSUES for SMAGP Gene

  • Intestine(4.2)
genes like me logo Genes that share expression patterns with SMAGP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SMAGP Gene

Orthologs for SMAGP Gene

This gene was present in the common ancestor of chordates.

Orthologs for SMAGP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SMAGP 34 33
  • 99.66 (n)
(Canis familiaris)
Mammalia SMAGP 34 33
  • 89.56 (n)
(Bos Taurus)
Mammalia SMAGP 34 33
  • 86.25 (n)
(Mus musculus)
Mammalia Smagp 16 34 33
  • 86.11 (n)
(Rattus norvegicus)
Mammalia Smagp 33
  • 85.07 (n)
(Ornithorhynchus anatinus)
Mammalia SMAGP 34
  • 50 (a)
(Anolis carolinensis)
Reptilia SMAGP 34
  • 47 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18833 33
Species where no ortholog for SMAGP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SMAGP Gene

Gene Tree for SMAGP (if available)
Gene Tree for SMAGP (if available)
Evolutionary constrained regions (ECRs) for SMAGP: view image

Paralogs for SMAGP Gene

(2) SIMAP similar genes for SMAGP Gene using alignment to 4 proteins:

  • S4R3E1_HUMAN
  • S4R405_HUMAN
  • S4R466_HUMAN
genes like me logo Genes that share paralogs with SMAGP: view

No data available for Paralogs for SMAGP Gene

Variants for SMAGP Gene

Sequence variations from dbSNP and Humsavar for SMAGP Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000154132 -- 51,250,750(-) T/A intron_variant
rs1000680074 -- 51,270,113(-) G/C 5_prime_UTR_variant, intron_variant
rs1000906103 -- 51,268,641(-) G/A intron_variant
rs1000976882 -- 51,256,645(-) A/G intron_variant
rs1001108702 -- 51,250,149(-) C/A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SMAGP Gene

Variant ID Type Subtype PubMed ID
esv3308888 CNV mobile element insertion 20981092
esv34039 CNV loss 18971310
nsv704 CNV insertion 18451855

Variation tolerance for SMAGP Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.83; 17.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMAGP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMAGP Gene

Disorders for SMAGP Gene

Additional Disease Information for SMAGP

No disorders were found for SMAGP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SMAGP Gene

Publications for SMAGP Gene

  1. SMAGP, a new small trans-membrane glycoprotein altered in cancer. (PMID: 15021913) Tarbé NG … Weidle UH (Oncogene 2004) 2 3 4 58
  2. Overexpression of the small transmembrane and glycosylated protein SMAGP supports metastasis formation of a rat pancreatic adenocarcinoma line. (PMID: 15986429) Tarbé NG … Zöller M (International journal of cancer 2005) 3 4 58
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58

Products for SMAGP Gene

Sources for SMAGP Gene

Loading form....