Aliases for SMAD9 Gene
External Ids for SMAD9 Gene
Previous HGNC Symbols for SMAD9 Gene
Previous GeneCards Identifiers for SMAD9 Gene
The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
GeneCards Summary for SMAD9 Gene
SMAD9 (SMAD Family Member 9) is a Protein Coding gene. Diseases associated with SMAD9 include Pulmonary Hypertension, Primary, 2 and Heritable Pulmonary Arterial Hypertension. Among its related pathways are Signaling pathways regulating pluripotency of stem cells and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity. An important paralog of this gene is SMAD1.
UniProtKB/Swiss-Prot Summary for SMAD9 Gene
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).