Aliases for SMAD9 Gene
External Ids for SMAD9 Gene
Previous HGNC Symbols for SMAD9 Gene
Previous GeneCards Identifiers for SMAD9 Gene
The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
GeneCards Summary for SMAD9 Gene
SMAD9 (SMAD Family Member 9) is a Protein Coding gene. Diseases associated with SMAD9 include Pulmonary Hypertension, Primary, 2 and Heritable Pulmonary Arterial Hypertension. Among its related pathways are Signaling by GPCR and Signaling by BMP. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity. An important paralog of this gene is SMAD1.
UniProtKB/Swiss-Prot Summary for SMAD9 Gene
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).