The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility... See more...

Aliases for SMAD7 Gene

Aliases for SMAD7 Gene

  • SMAD Family Member 7 2 3 4 5
  • Mothers Against Decapentaplegic Homolog 7 3 4
  • Mothers Against DPP Homolog 8 3 4
  • MAD Homolog 8 3 4
  • HSMAD7 3 4
  • MADH7 3 4
  • MADH8 3 4
  • MAD, Mothers Against Decapentaplegic Homolog 7 (Drosophila) 2
  • MAD (Mothers Against Decapentaplegic, Drosophila) Homolog 7 3
  • Mothers Against Decapentaplegic, Drosophila, Homolog Of, 7 3
  • SMAD, Mothers Against DPP Homolog 7 (Drosophila) 2
  • Mothers Against Decapentaplegic Homolog 8 4
  • SMAD, Mothers Against DPP Homolog 7 3
  • Mothers Against DPP Homolog 7 4
  • MAD Homolog 7 4
  • SMAD 7 4
  • CRCS3 3
  • SMAD7 5
  • Smad7 4

External Ids for SMAD7 Gene

Previous HGNC Symbols for SMAD7 Gene

  • MADH8
  • MADH7

Previous GeneCards Identifiers for SMAD7 Gene

  • GC18M044699
  • GC18M044700
  • GC18M046446
  • GC18M043299

Summaries for SMAD7 Gene

Entrez Gene Summary for SMAD7 Gene

  • The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for SMAD7 Gene

SMAD7 (SMAD Family Member 7) is a Protein Coding gene. Diseases associated with SMAD7 include Colorectal Cancer 3 and Breast Cancer. Among its related pathways are Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is SMAD6.

UniProtKB/Swiss-Prot Summary for SMAD7 Gene

  • Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Gene Wiki entry for SMAD7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for SMAD7 Gene

Genomics for SMAD7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for SMAD7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SMAD7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for SMAD7

Top Transcription factor binding sites by QIAGEN in the SMAD7 gene promoter:
  • AhR
  • HFH-1
  • HNF-4alpha1
  • MyoD
  • p300
  • Pax-5
  • STAT1

Genomic Locations for SMAD7 Gene

Latest Assembly
chr18:48,919,853-48,952,052
(GRCh38/hg38)
Size:
32,200 bases
Orientation:
Minus strand

Previous Assembly
chr18:46,446,223-46,477,335
(GRCh37/hg19 by Entrez Gene)
Size:
31,113 bases
Orientation:
Minus strand

chr18:46,446,223-46,477,081
(GRCh37/hg19 by Ensembl)
Size:
30,859 bases
Orientation:
Minus strand

Genomic View for SMAD7 Gene

Genes around SMAD7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SMAD7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SMAD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SMAD7 Gene

Proteins for SMAD7 Gene

  • Protein details for SMAD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15105-SMAD7_HUMAN
    Recommended name:
    Mothers against decapentaplegic homolog 7
    Protein Accession:
    O15105
    Secondary Accessions:
    • B7Z773
    • K7EQ10
    • O14740
    • Q6DK23

    Protein attributes for SMAD7 Gene

    Size:
    426 amino acids
    Molecular mass:
    46426 Da
    Quaternary structure:
    • Interacts with WWP1 (By similarity). Interacts with COPS5. Interacts with NEDD4L. Interacts with STAMBP. Interacts with RNF111, AXIN1 and AXIN2. Interacts with PPP1R15A. Interacts (via MH2 domain) with EP300. Interacts with ACVR1B, SMURF1, SMURF2 and TGFBR1; SMAD7 recruits SMURF1 and SMURF2 to the TGF-beta receptor and regulates its degradation. Interacts with PDPK1 (via PH domain).

    Three dimensional structures from OCA and Proteopedia for SMAD7 Gene

    Alternative splice isoforms for SMAD7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SMAD7 Gene

Post-translational modifications for SMAD7 Gene

  • Phosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling; however it affects its ability to regulate transcription (By similarity). Phosphorylated by PDPK1.
  • Ubiquitinated by WWP1 (By similarity). Polyubiquitinated by RNF111, which is enhanced by AXIN1 and promotes proteasomal degradation (PubMed:14657019, PubMed:16601693). In response to TGF-beta, ubiquitinated by SMURF1; which promotes its degradation (PubMed:11278251).
  • Acetylation prevents ubiquitination and degradation mediated by SMURF1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SMAD7 Gene

No data available for DME Specific Peptides for SMAD7 Gene

Domains & Families for SMAD7 Gene

Gene Families for SMAD7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for SMAD7 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ57868, highly similar to Mothers against decapentaplegic homolog 7 (SMAD 7) (B7Z773_HUMAN)
  • SMAD family member 7 (SMAD7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O15105

UniProtKB/Swiss-Prot:

SMAD7_HUMAN :
  • Belongs to the dwarfin/SMAD family.
Family:
  • Belongs to the dwarfin/SMAD family.
genes like me logo Genes that share domains with SMAD7: view

Function for SMAD7 Gene

Molecular function for SMAD7 Gene

UniProtKB/Swiss-Prot Function:
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
UniProtKB/Swiss-Prot Induction:
By TGFB1.

Phenotypes From GWAS Catalog for SMAD7 Gene

Gene Ontology (GO) - Molecular Function for SMAD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IEA,IPI 14993265
GO:0005518 collagen binding IEA --
GO:0008013 beta-catenin binding IPI 18593713
genes like me logo Genes that share ontologies with SMAD7: view
genes like me logo Genes that share phenotypes with SMAD7: view

Human Phenotype Ontology for SMAD7 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SMAD7 Gene

MGI Knock Outs for SMAD7:

miRNA for SMAD7 Gene

miRTarBase miRNAs that target SMAD7

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMAD7

Clone products for research

  • Addgene plasmids for SMAD7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SMAD7 Gene

Localization for SMAD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SMAD7 Gene

Nucleus. Cytoplasm. Note=Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). {ECO:0000269 PubMed:16601693, ECO:0000269 PubMed:17327236}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SMAD7 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 4
extracellular 3
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SMAD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IEA,IDA 11278251
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with SMAD7: view

Pathways & Interactions for SMAD7 Gene

genes like me logo Genes that share pathways with SMAD7: view

Pathways by source for SMAD7 Gene

3 GeneGo (Thomson Reuters) pathways for SMAD7 Gene
  • Development_TGF-beta receptor signaling
  • Immune response IFN gamma signaling pathway
  • Signal transduction Activin A signaling regulation
1 R&D Systems pathway for SMAD7 Gene
1 GeneTex pathway for SMAD7 Gene

SIGNOR curated interactions for SMAD7 Gene

Gene Ontology (GO) - Biological Process for SMAD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 17438144
GO:0001657 ureteric bud development IEA --
GO:0002725 negative regulation of T cell cytokine production ISS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with SMAD7: view

Drugs & Compounds for SMAD7 Gene

(9) Drugs for SMAD7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(9) Additional Compounds for SMAD7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SMAD7: view

Transcripts for SMAD7 Gene

mRNA/cDNA for SMAD7 Gene

4 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SMAD7

Clone products for research

  • Addgene plasmids for SMAD7

Alternative Splicing Database (ASD) splice patterns (SP) for SMAD7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5: -
SP6:

Relevant External Links for SMAD7 Gene

GeneLoc Exon Structure for
SMAD7

Expression for SMAD7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SMAD7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SMAD7 Gene

This gene is overexpressed in Artery - Tibial (x4.9) and Heart - Atrial Appendage (x4.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for SMAD7

SOURCE GeneReport for Unigene cluster for SMAD7 Gene:

Hs.465087

mRNA Expression by UniProt/SwissProt for SMAD7 Gene:

O15105-SMAD7_HUMAN
Tissue specificity: Ubiquitous with higher expression in the lung and vascular endothelium.

Evidence on tissue expression from TISSUES for SMAD7 Gene

  • Heart(4.6)
  • Lung(4.6)
  • Nervous system(4.5)
  • Muscle(3.1)
  • Kidney(3)
  • Blood(2.7)
  • Liver(2.7)
  • Intestine(2.7)
  • Skin(2.6)
  • Bone marrow(2.6)
  • Lymph node(2.4)
  • Spleen(2.3)
  • Thyroid gland(2.3)
  • Stomach(2.2)
  • Pancreas(2.2)
  • Bone(2)
genes like me logo Genes that share expression patterns with SMAD7: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SMAD7 Gene

Orthologs for SMAD7 Gene

This gene was present in the common ancestor of animals.

Orthologs for SMAD7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia SMAD7 29 30
  • 99.77 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia SMAD7 30
  • 97 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Smad7 29 16 30
  • 95.38 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia SMAD7 29 30
  • 95.28 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Smad7 29
  • 94.99 (n)
Cow
(Bos Taurus)
Mammalia SMAD7 29 30
  • 94.99 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia SMAD7 30
  • 89 (a)
OneToOne
Chicken
(Gallus gallus)
Aves SMAD7 29 30
  • 78.12 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia SMAD7 30
  • 95 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia smad7 29
  • 79.09 (n)
Str.18078 29
African clawed frog
(Xenopus laevis)
Amphibia madh7 29
Zebrafish
(Danio rerio)
Actinopterygii smad7 29 30
  • 77.06 (n)
OneToOne
madh7 29
Fruit Fly
(Drosophila melanogaster)
Insecta Dad 30
  • 21 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea daf-8 30
  • 16 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9437 30
  • 35 (a)
OneToMany
Species where no ortholog for SMAD7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for SMAD7 Gene

ENSEMBL:
Gene Tree for SMAD7 (if available)
TreeFam:
Gene Tree for SMAD7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SMAD7: view image
Alliance of Genome Resources:
Additional Orthologs for SMAD7

Paralogs for SMAD7 Gene

Paralogs for SMAD7 Gene

(3) SIMAP similar genes for SMAD7 Gene using alignment to 2 proteins:

  • SMAD7_HUMAN
  • K7EKF0_HUMAN
genes like me logo Genes that share paralogs with SMAD7: view

Variants for SMAD7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for SMAD7 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
rs1035236065 Likely Benign: not provided 48,950,241(-) G/A
NM_005904.3(SMAD7):c.184C>T (p.Leu62=)
SYNONYMOUS
rs144204026 Benign: not provided 48,950,310(-) C/T
NM_005904.3(SMAD7):c.115G>A (p.Gly39Arg)
MISSENSE
rs145686330 Benign: not provided. Benign: not provided 48,948,427(-) G/AG/T
NM_005904.3(SMAD7):c.624C>T (p.Pro208=)
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR
rs149492644 Benign: not provided 48,921,567(-) G/A
NM_005904.3(SMAD7):c.1086C>T (p.Pro362=)
SYNONYMOUS
rs4939827 Risk Factor: Colorectal cancer 3 48,927,093(-) T/.
NM_005904.3(SMAD7):c.743-5183=
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for SMAD7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for SMAD7 Gene

Variant ID Type Subtype PubMed ID
nsv473308 CNV novel sequence insertion 20440878
nsv833644 CNV gain 17160897
nsv833645 CNV loss 17160897

Variation tolerance for SMAD7 Gene

Residual Variation Intolerance Score: 19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SMAD7 Gene

Human Gene Mutation Database (HGMD)
SMAD7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SMAD7
Leiden Open Variation Database (LOVD)
SMAD7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SMAD7 Gene

Disorders for SMAD7 Gene

MalaCards: The human disease database

(26) MalaCards diseases for SMAD7 Gene - From: LNC, OMI, CVR, GTR, COP, and GCD

Disorder Aliases PubMed IDs
colorectal cancer 3
  • colorectal cancer, susceptibility to, 3
breast cancer
  • breast cancer, familial
colitis
fibrodysplasia ossificans progressiva
  • fop
ulcerative colitis
  • left-sided ulcerative colitis
- elite association - COSMIC cancer census association via MalaCards
Search SMAD7 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SMAD7_HUMAN
  • Colorectal cancer 3 (CRCS3) [MIM:612229]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. {ECO:0000269 PubMed:17934461}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Additional Disease Information for SMAD7

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with SMAD7: view

No data available for Genatlas for SMAD7 Gene

Publications for SMAD7 Gene

  1. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. (PMID: 17934461) Broderick P … Houlston RS (Nature genetics 2007) 3 4 40 72
  2. Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. (PMID: 9256479) Topper JN … Falb D (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22
  3. Increased risk of colon cancer associated with a genetic polymorphism of SMAD7. (PMID: 20124488) Slattery ML … Peters U (Cancer research 2010) 3 22 40
  4. A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. (PMID: 18372905) Tomlinson IP … Houlston RS (Nature genetics 2008) 3 40 72
  5. Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. (PMID: 18372901) Tenesa A … Dunlop MG (Nature genetics 2008) 3 40 72

Products for SMAD7 Gene

  • Addgene plasmids for SMAD7

Sources for SMAD7 Gene